A5100435721- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological Disease Mechanisms and Treatments
- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Pharmacological Effects of Natural Compounds
- Multiple Sclerosis Research Studies
- Traditional Chinese Medicine Analysis
- Neurogenesis and neuroplasticity mechanisms
- Nerve injury and regeneration
- Plant-based Medicinal Research
- Pharmacogenetics and Drug Metabolism
- Barrier Structure and Function Studies
- Neuroscience and Neuropharmacology Research
- Circular RNAs in diseases
- Medicinal Plant Pharmacodynamics Research
- Cytokine Signaling Pathways and Interactions
- Transcranial Magnetic Stimulation Studies
- Axon Guidance and Neuronal Signaling
- Cancer-related molecular mechanisms research
- Neurological Disorders and Treatments
- Medicinal Plants and Bioactive Compounds
- Muscle activation and electromyography studies
- Computational Drug Discovery Methods
- Advanced biosensing and bioanalysis techniques
- Chromatography in Natural Products
Second Military Medical University
2022-2025
Changhai Hospital
2022-2025
Wuhan University
2022-2024
Guangzhou University of Chinese Medicine
2024
Infinitus (China)
2024
Renmin Hospital of Wuhan University
2022-2024
Tianjin Institute of Pharmaceutical Research (China)
2024
Anhui University of Traditional Chinese Medicine
2021-2023
Capital Medical University
2014-2023
Capital University
2017-2023
The intrinsic ability of neurogenesis after stroke has been proven weak, which results in insufficient repair injury the nerve system. Recent studies suggest multiple microRNAs (miRNAs) are involved neuroremodeling process. Targeted miRNAs delivery for amplification is promising promoting prognosis ischemia. Here, we showed that modified exosomes, with rabies virus glycoprotein (RVG) fused to exosomal protein lysosome-associated membrane 2b (Lamp2b), could efficiently deliver miR-124 infarct...
Introduction: Puerarin (PUE) is a natural compound isolated from Puerariae Lobatae Radix, which has neuroprotective effect on IS. We explored the therapeutic and underlying mechanism of PUE cerebral I/R injury by inhibiting oxidative stress related to PI3K/Akt/Nrf2 pathway in vitro vivo. Methods: The middle artery occlusion reperfusion (MCAO/R) rats oxygen-glucose deprivation (OGD/R) were selected as models, respectively. was observed using triphenyl tetrazolium hematoxylin-eosin staining....
Following stroke, microglia can be driven to the "classically activated" pro-inflammatory (M1) phenotype and "alternatively anti-inflammatory (M2) phenotype. Salidroside (SLDS) is known inhibit inflammation possess protective effects in neurological diseases, but date, exact mechanisms involved these processes after stroke have yet elucidated. The purpose of this study was determine SLDS on neuroprotection microglial polarization stroke.Male adult C57/BL6 mice were subjected focal transient...
2,3,5,6-Tetramethylpyrazine (TMP) as an active ingredient extracted from a traditional Chinese herbal medicine Ligusticum chuanxiong Hort . has been proved to penetrate blood-brain barrier (BBB) and show neuroprotective effects on cerebral ischemia. However, whether TMP could regulate astrocytic reactivity facilitate neurovascular restoration in the subacute ischemic stroke needs be urgently verified. In this research, permanent occlusion of middle artery (MCAO) model was conducted (10, 20,...
The exosome is a promising biomarker carrying many kinds of membrane proteins with huge heterogeneity, so the sensitive and multiplex analysis exosomes very significant for disease diagnosis exploration their biological functions. Herein, we propose an efficient method highly detection heterogeneity identification based on design fabrication aptamer-coated liposome complex coupled terminal deoxynucleotidyl transferase (TdT)-mediated polymerization. Specifically, in presence target exosomes,...
Acetaminophen (APAP) overdose is one of the leading causes hepatotoxicity and acute liver failure in United States. Accumulating evidence suggests that hepatocyte necrosis plays a critical role APAP‐induced injury (AILI). However, mechanisms are not fully understood. In this study, we found p53 up‐regulated modulator apoptosis (PUMA), B‐cell lymphoma‐2 (Bcl‐2) homology domain 3 (BH3)‐only Bcl‐2 family member, was markedly induced by APAP mouse livers isolated human hepatocytes. PUMA...
Ischemic stroke (IS) is characterized by the rapid loss of brain function due to ischemia. Physcion has been found have a neuroprotective effect against cerebral ischemia-reperfusion (I/R) injury. However, mechanism which physcion regulates I/R injury remains largely unknown.An oxygen-glucose deprivation/reperfusion (OGD/R) model in SH-SY5Y cells and rat were established, respectively. CCK-8 flow cytometry assays used detect viability apoptosis cells. Moreover, enzyme-linked immunosorbent...
A simple and sensitive method for exosome detection based on steric hindrance-controlled signal amplification.
Bu Shen Yi Sui capsule (BSYS) is a traditional Chinese medicine prescription that has shown antineuroinflammatory and neuroprotective effects in treating multiple sclerosis (MS) its animal model of experimental autoimmune encephalomyelitis (EAE). Microglia play an important role neuroinflammation. The M1 phenotype microglia involved the proinflammatory process disease, while M2 plays anti-inflammatory role. Promoting polarization to MS/EAE promising therapeutic strategy. This study aimed at...
Abstract Atherosclerosis is a complex pathological process involving macrophages, endothelial cells and vascular smooth muscle that can lead to ischemic heart disease; however, the mechanisms underlying cell‐to‐cell communication in atherosclerosis are poorly understood. In this study, we focused on role of exosomal miRNAs crosstalk between macrophages explored rarely studied molecular involved. Our vitro result showed macrophage‐derived miR‐4532 significantly disrupted human umbilical vein...
(-)-Epigallocatechin-3-gallate (EGCG), the main bioactive component of tea catechins, exhibits broad-spectrum health efficacy against mitochondrial damage after subarachnoid hemorrhage (SAH). The mechanisms, however, are largely unknown. Here, ability EGCG to rescue dysfunction and dynamics following inhibition cell death was investigated by using in vitro vivo SAH models. blocked cytosolic channel ([Ca2+])i influx via voltage-gated calcium channels (VGCCs), which induced dysfunction,...
Tibal dyschondroplasia (TD) is main bone problem in fast growing poultry birds that effect proximal growth plate of tibia bone. TD broadly defined as non-vascularized and non-mineralized, enlarged GP with deformation lameness. Icariin (Epimedium sagittatum) a traditional Chinese medicine, which commonly practiced the treatment various diseases. Recently, many researcher reports about beneficial effects relation to types conditions but no report available promoting icariin against TD....
The neuroprotective effects of hypothermia in acute ischemic stroke are well documented. However, the mechanisms involved remain to be clearly elucidated and role on long-term white matter integrity after has yet investigated.To investigate mild focal (WM) transient cerebral ischemia.Mild treatment immediately significantly promotes WM 28 days occlusion middle artery (MCAO) mice. Higher matter, lower activation total microglia, less infarct volume, better neurobehavioral function were...
Diagnosis of pancreatic cancer (Pca) is challenging. This study investigated the value plasma-derived exosome miR-19b (Exo-miR-19b) in diagnosing patients with Pca. Plasma was collected from 62 Pca, 30 other tumor (OPT), 23 chronic pancreatitis (CP), and 53 healthy volunteers. MiR-19b levels exosomes were detected. Plasma-derived Exo-miR-19b normalized using miR-1228 significantly lower Pca than OPT, CP patients, The diagnostic values superior to those serum antigen 19-9 (CA19-9)...
T helper (Th) 17 and regulatory (Treg) cells play a critical role in the pathogenesis of multiple sclerosis (MS) disease. Bu Shen Yi Sui Capsule (BSYSC), traditional Chinese medicine formula, has been used clinically for treatment MS patients China. To evaluate neuroprotective effects underlying mechanisms BSYSC on MS, experimental autoimmune encephalomyelitis (EAE) model C57BL/6 mice was induced with myelin oligodendrocyte glycoprotein (MOG) 35–55. Th17 Treg related cytokines were detected...