A5020891896- Ubiquitin and proteasome pathways
- RNA modifications and cancer
- Cancer survivorship and care
- Cancer-related molecular mechanisms research
- Peptidase Inhibition and Analysis
- Lung Cancer Treatments and Mutations
- RNA Research and Splicing
- Lung Cancer Diagnosis and Treatment
- Telemedicine and Telehealth Implementation
- Esophageal Cancer Research and Treatment
- Higher Education and Teaching Methods
- Health, psychology, and well-being
- Lung Cancer Research Studies
- Cancer, Hypoxia, and Metabolism
- Immune cells in cancer
- Health and Wellbeing Research
- Immunotherapy and Immune Responses
- MicroRNA in disease regulation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Health disparities and outcomes
- Cytokine Signaling Pathways and Interactions
- Cancer-related gene regulation
- Family Support in Illness
- Autophagy in Disease and Therapy
- Psoriasis: Treatment and Pathogenesis
Zhejiang University of Technology
2022-2024
Peking University
2024
Peking University Cancer Hospital
2024
Kunming Medical University
2022-2024
People's Liberation Army Air Force
2024
Chinese PLA General Hospital
2023
Chinese People's Liberation Army
2023
Fudan University
2019-2022
Nanjing Medical University
2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2022
Cisplatin remains the standard first-line chemotherapeutic agent in treatment of many types cancers, but its clinical application is hindered by severe nephrotoxicity. Previous studies reported that scutellarin enhanced anti-cancer activity cisplatin lung cancer cells, with no confirmation on cisplatin-induced renal damage. Here, we investigated nephroprotective effect injury and underlying mechanisms. Renal function, histological change, inflammation, apoptosis, autophagy involved pathways...
Physical activity and good nutrition are important behavioral factors in promoting health preventing disease. It is to understand the affecting physical nutrition. The purpose of this study was explore whether social capital has an effect on nutrition, literacy plays a mediating role between as well nutrition.This cross-sectional performed certain district Shanghai March April 2017. Data collected using self-reported questionnaire, which included questions sociodemographic characteristics,...
Bladder cancer(BC)is one of the most common urinary system tumors, which characterized by a high incidence. Polyporus polysaccharide is main active component polyporus, clinically used in treatment bladder cancer, but mechanism not clear. In previous study, we isolated homogeneous polyporus polysaccharide(HPP) with purity from polyporus. The goal this study was to assess polarization macrophages induced HPP tumor microenvironment and explored its anti-bladder cancer through BBN rat model...
Abstract Background Breast cancer is a common tumor in China and has become public health problem modern society. Stress plays an important role the occurrence progression of cancer. At present, current situation stress on breast survivors (BCSs) not been fully understood. This study aims to explore coping strategies Chinese BCSs, which provide suggestions help BCSs reduce stress. Methods Sixty-three from Shanghai Cancer Rehabilitation Club were included this divided into eight focus groups....
Psoriasis is a chronic and inflammatory skin disorder characterized by inflammation epidermal hyperplasia. Punicalagin (PUN) main active ingredient of pomegranate (Punica granatum L.) peel with multiple biological activities, such as antibacterial, antioxidant anti-tumor effects. However, the potential effect PUN on psoriasis remains unknown. In this study, we want to investigate pharmacological using imiquimod (IMQ)-induced psoriatic mice model in vivo tumor necrosis factor (TNF-α)...
Hepatocellular carcinoma (HCC) is a common malignant tumor associated with poor prognosis. Ubiquitin carboxyl-terminal hydrolase L3 (UCHL3) has been reported to promote diverse tumors, but little known about its role in HCC.Expression levels of UCHL3 Huh7 and Hep3B cells were measured by qRT-PCR. UCHL3, Vimentin protein levels, ubiquitination determined Western blot assay. co-immunoprecipitation, Immunofluorescence, IHC used detect the interaction expression association between cells. Wound...
The discovery of new therapeutic drugs with the efficacious and safe ability to prevent epidermal hyperplasia is extremely urgent for psoriasis. Cryptotanshinone (CTS), an active component isolated from root Salvia miltiorrhiza Bunge, has been reported have antibacterial antitumor effects. However, its effects on psoriasis not reported. Here, we investigated CTS imiquimod (IMQ)-induced psoriatic-like skin model explored underlying mechanisms. Our results revealed that effectively alleviates...
Abstract Psoriasis is a common chronic skin disease characterized by epidermal hyperplasia and inflammation. However, the pathogenesis of psoriasis multifactorial not fully understood. MicroRNAs (miRNAs) represent promising class small, noncoding RNA molecules that have large impact on cellular functions regulating gene expression. Here we reported microRNA‐187 (miR‐187), which one most dynamic microRNAs identified in deep screening miRNAs profile, downregulated inflammatory...
Abstract Programmed death ligand 1 (PD‐L1) is widely known as an immune checkpoint, and immunotherapy through the inhibition of checkpoint molecules has become important component in successful treatment tumours via programmed (PD‐1)/PD‐L1 signalling pathways. However, its biological functions expression profile colorectal cancer (CRC) are elusive. We previously found that PD‐L1 can bind to cause cell detachment. detailed molecular mechanisms how binds it transmits signals remain unclear. In...
Background: Since the coronavirus disease 2019 (COVID-19) outbreak in Wuhan late 2019, China has been implementing an unprecedented quarantine strategy covering City's entire population, with all citizens required to stay at home. This exploratory study investigated impact of living circumstances those quarantined gain insight into their levels perceived stress.Methods: In a cross-sectional carried out between February 28 and March 2, 2020, using on-line questionnaire, we recruited 1,383...
Abstract This study aims to investigate the serial multiple mediation of physical activity and perceived stress in relationship between individual social capital quality life (QOL) breast cancer survivors (BCSs). was conducted among 520 BCSs March April 2017 Shanghai, China. Data were collected using Individual Social Capital Scale, Health-Promoting Lifestyle Profile-II, Perceived Stress Scale-14 EORTC QLQ-C30. Ordinary least-squares regression bootstrap method used test significance model....
Pancreatic ductal adenocarcinoma (PDAC) is a noteworthy malignant carcinoma with an unsatisfactory prognosis attributed to late diagnosis. Ubiquitin‑conjugating enzyme E2K (UBE2K) has been found serve important roles in number of diseases. However, its function and the exact molecular mechanism UBE2K PDAC remain be elucidated. The present study discovered that was expressed at high levels indicated poor patients PDAC. Following this, CCK‑8, colony formation, sphere formation assays showed...
Patients with advanced intrahepatic cholangiocarcinoma (iCCA) often have a poor prognosis. Recent advancements in targeted molecular therapy and immunotherapy been made. Herein, we report case of iCCA treated combination pemigatinib (a selective FGFR inhibitor), chemotherapy, an immune checkpoint inhibitor. A 34-year-old female was diagnosed multiple liver masses metastases the peritoneum lymph nodes. Next-generation sequencing (NGS) identified genetic mutations. An FGFR2-BICC1 gene fusion...
Breast cancer, the most common malignant tumor in women, has become a worldwide burden for family and society. MicroRNAs (miRNAs or miRs) are recognized as critical mediators of cancer-related processes, since they have ability to coordinately suppress multiple target genes. In this study, we aim find out specific miRNAs involved progression breast cancer explore underlying molecular mechanism. Bioinformatics analysis suggested miR-301 differentially overexpressed miRNA which was confirmed...
Abstract Background The present study aimed to develop and test an extended theory of planned behavior (TPB), which includes attitudes, subjective norms perceived behavioral control, oral health knowledge, past on the intention improve behaviors among primary school students in Shanghai, China. Methods A school-based cross-sectional was conducted with 414 third-grade from 10 classes Mingqiang Primary School located Participants were recruited October 2019. Data collected through...
Long noncoding RNAs (lncRNAs) are confirmed as the key regulators of hepatocellular carcinoma (HCC) occurrence and progression, but role AlkB homologue 3 antisense RNA 1 (ALKBH3-AS1) in HCC is unclear. We revealed overexpression ALKBH3-AS1 tissues. The upregulated levels were observed cells. was expressed nucleus cytoplasm high expression markedly associated with a decreased survival rate patients. knockdown repressed enhanced cell invasion proliferation. silencing restricted growth vivo. A...
Colorectal cancer (CRC) is one of the most common gastrointestinal malignancies. Vasorin (VASN) has been reported to be critical in tumor development and angiogenesis. However, VASN not CRC, its role unclear. In this study, expression upregulated CRC compared with normal tissues, positively correlates N stage poor overall survival by analysis different datasets 32 clinicopathologic samples. Overexpression significantly promotes cell progression, including proliferation, migration, invasion,...
Achieving good oral health-related quality of life (OHRQOL) is particular concern in children. The inter-relations among health knowledge, self-efficacy, behaviours and OHRQOL children groups remain unclear. This study aimed to explore the between these behaviour-related factors primary school children.In this cross-sectional study, 651 grades 2 3 were recruited October 2020 from two schools Minhang District, Shanghai, China. Data collected through self-reported questionnaires, consisting...
Abstract Background Hepatocellular carcinoma (HCC) ranks as the second leading cause of global cancer-related deaths and is characterized by a poor prognosis. Eukaryotic translation elongation factor 1 alpha (EEF1A1) have been proved to play important roles in various human cancers, whereas deubiquitination EEF1A1 was poorly understood. Methods The binding regulatory relationship between Ubiquitin carboxyl-terminal hydrolase L3 (UCHL3) validated using clinical tissue samples, reverse...
Plasma metabolic profiles in 26 PC patients, 27 DM and 23 healthy volunteers were examined using an ultraperformance liquid chromatography coupled with tandem mass spectrometry platform. Differential metabolite ions then identified the principal component analysis (PCA) model orthogonal partial least-squares discrimination (OPLS-DA) model. The diagnosis performance of biomarkers was validated by logistic regression models.We established a PCA (R2X = 23.5%, Q2 8.21%) OPLS-DA 70.0%, R2Y 84.9%,...