A5057072589- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Ubiquitin and proteasome pathways
- Kruppel-like factors research
- Cancer-related gene regulation
- Cancer Genomics and Diagnostics
- Autophagy in Disease and Therapy
- Pancreatic and Hepatic Oncology Research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer Cells and Metastasis
- Genetics and Neurodevelopmental Disorders
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- Ferroptosis and cancer prognosis
- Cancer Mechanisms and Therapy
- PI3K/AKT/mTOR signaling in cancer
- Hepatocellular Carcinoma Treatment and Prognosis
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Histone Deacetylase Inhibitors Research
- Cancer-related Molecular Pathways
- Chronic Myeloid Leukemia Treatments
- Cellular transport and secretion
- Drug Transport and Resistance Mechanisms
- Ion Transport and Channel Regulation
Zhejiang Provincial People's Hospital
2017-2024
Hangzhou Medical College
2018-2024
First Affiliated Hospital of Xi'an Jiaotong University
2022
Zhejiang University
2015-2018
Abstract The major function of Insulin-like growth factor 2 mRNA-binding protein (IGF2BP2) is to regulate cell metabolism. However, emerging evidence indicates that IGF2BP2 plays a role in cancer, but the underlying mechanism largely unknown. Here we showed upregulation associated with poor outcomes pancreatic cancer patients and suppression inhibits proliferation. We further regulates lncRNA DANCR. Ectopic expression enhances, whereas knockdown (KD) or knockout (KO) suppresses DANCR...
Pancreatic ductal adenocarcinoma (PDAC) is one of the leading causes cancer death, partly due to high recurrence rates for patients with PDAC. Current postoperative surveillance methods, including monitoring clinical symptoms, tumor markers, and CT imaging, lack sensitivity specificity minimal residual disease (MRD). We investigated whether detection circulating DNA (ctDNA) could identify MRD predict relapse in In this study, we performed panel-captured sequencing detect somatic mutations....
Neuroligins (NLs) are a group of postsynaptic cell adhesion molecules that function in synaptogenesis and synaptic transmission. Genetic defects neuroligin 3 (NL3), member the NL protein family, associated with autism. Studies rodents have revealed mutations NL3 gene lead to increased growth complexity dendrites central nervous system. However, detailed mechanism is still unclear. In our study, we found deficiency led morphological changes pyramidal neurons layer II/III somatosensory cortex...
Abstract Background Hepatocellular carcinoma (HCC) is a prevalent malignant tumor that poses major threat to people’s lives and health. Previous studies have found multiple deubiquitinating enzymes are involved in the pathogenesis of HCC. The purpose this work was elucidate function mechanism enzyme USP40 HCC progression. Methods expression human tissues cell lines investigated using RT-qPCR, western blotting immunohistochemistry (IHC). Both vitro vivo experiments were conducted determine...
Quiescent caner stem cells are identified as a subpopulation of colon cancer in dormant state and possess strong stem-cell like characteristics. Previously, we have this colorectal (quiescent cells, QCCSCs), find QCCSCs sensitive to the apoptotic effect IFN-γ, which is attributed their high IFN-γR expression levels. Microarray bioinformatic analysis indicate miR-4666-3p low expressed target IFN-γR1/2, proved by luciferase assay western-blot. Furthermore, could also TGF-βR1 block activation...
Abstract Background Pancreatic cancer (PC) is one of the most malignant cancers with highly aggressiveness and poor prognosis. N6-methyladenosine (m6A) have been indicated to be involved in PC development. Glucan Branching Enzyme 1 (GBE1) mainly cell glycogen metabolism. However, function GBE1 Whether occurs m6A modification progression remains illustrated. Methods The clinical prognosis was analyzed through online platform. expression obtained from platform then verified normal lines....
Abstract Background Hepatocellular carcinoma (HCC) ranks as the second leading cause of global cancer-related deaths and is characterized by a poor prognosis. Eukaryotic translation elongation factor 1 alpha (EEF1A1) have been proved to play important roles in various human cancers, whereas deubiquitination EEF1A1 was poorly understood. Methods The binding regulatory relationship between Ubiquitin carboxyl-terminal hydrolase L3 (UCHL3) validated using clinical tissue samples, reverse...
Hepatocellular carcinoma (HCC) is the most common malignancy of liver. Genomic analysis conducted to identify genetic alterations in driver genes which are all druggable targets for cancer therapy. In present study, we performed an exome sequencing 45 100 paired samples from HCC patients including tumors and matched adjacent normal tissues using Illumina HiSeq 2000 platform. Non-synonymous mutations were ascertained iPLEX MassARRAY system Sanger sequencing. Clinicopathological relevance with...
Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer and second leading cause deaths in word. Hepatitis B virus (HBV) infection plays an important role development HCC. However, mechanisms by which HBV integration affects host cells remain poorly understood. HepG2.2.15 cell line derived from HCC HepG2 with stable transfection expression. In this study, showed decreased proliferation, G1 cycle arrest increased apoptosis, when compared to cells. capture sequencing was...
Pancreatic ductal adenocarcinoma (PDAC) is a noteworthy malignant carcinoma with an unsatisfactory prognosis attributed to late diagnosis. Ubiquitin‑conjugating enzyme E2K (UBE2K) has been found serve important roles in number of diseases. However, its function and the exact molecular mechanism UBE2K PDAC remain be elucidated. The present study discovered that was expressed at high levels indicated poor patients PDAC. Following this, CCK‑8, colony formation, sphere formation assays showed...
Abstract Background Long noncoding RNAs (lncRNAs) are implicated in the initiation and progression of diffuse large B-cell lymphoma (DLBCL). Small nucleolar RNA host gene 20 (SNHG20) has been recognized as a critical lncRNA multiple human cancers. However, role SNHG20 its underlying mechanism DLBCL still unclear. Methods The expression levels SNHG20, c-MYC, β-catenin, ubiquitin-specific peptidase 14 (USP14) were measured by reverse transcription-quantitative polymerase chain reaction...
Although most gastrointestinal tumours are sensitive to 5-fluorouracil (5FU), drug resistance is commonly occurred after 5FU therapy in gastric cancer (GC). Loganetin the primary active compound Cornus officinali. However, synergetic effects of loganetin and on GC remain unknown. Here, we investigated underlying mechanism proliferation, stem-like properties, migration, invasion both vitro vivo. We found that alone inhibited migration cells vitro. Importantly, remarkably enhanced anti-cancer...
Digestive system cancers are the leading cause of cancer‑related death worldwide due to their high morbidity and mortality rates. The current treatment methods include surgical treatment, chemotherapy, radiotherapy endoscopic precisely targeted therapy digestive requires be further studied. ubiquitin‑proteasome is main pathway for protein degradation in cells ubiquitin‑conjugating enzymes (E2s) have a decisive role specific selection target proteins degradation. E2s an important...
With the increase of treatment course, resistance to EGFR blockade is inevitable in patients with metastatic colorectal cancer (mCRC). KRAS mutations have been considered be primary drivers this resistance; however, potential function other genes has not extensively investigated. This study collected 17 plasma samples from mCRC cetuximab resistance, and target-capture deep sequencing was used identify circulating tumor DNA (ctDNA). Analysis mutational prevalence ctDNA performed three...