A5004810571- Kruppel-like factors research
- Ubiquitin and proteasome pathways
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- MicroRNA in disease regulation
- Colorectal Cancer Treatments and Studies
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cancer-related gene regulation
- Genetics, Aging, and Longevity in Model Organisms
- Protein Degradation and Inhibitors
- Cancer Mechanisms and Therapy
- Congenital heart defects research
- Pancreatic and Hepatic Oncology Research
- Plant Molecular Biology Research
- Estrogen and related hormone effects
- Signaling Pathways in Disease
- Endoplasmic Reticulum Stress and Disease
- Neurogenesis and neuroplasticity mechanisms
- Epigenetics and DNA Methylation
- Biological and pharmacological studies of plants
- PI3K/AKT/mTOR signaling in cancer
- Cancer Immunotherapy and Biomarkers
- Histone Deacetylase Inhibitors Research
- Genetic factors in colorectal cancer
- Wnt/β-catenin signaling in development and cancer
Hangzhou Medical College
2018-2025
Zhejiang Provincial People's Hospital
2018-2025
Sun Yat-sen University
2022-2024
The Seventh Affiliated Hospital of Sun Yat-sen University
2022-2024
Zhejiang Sci-Tech University
2018-2020
Abstract The major function of Insulin-like growth factor 2 mRNA-binding protein (IGF2BP2) is to regulate cell metabolism. However, emerging evidence indicates that IGF2BP2 plays a role in cancer, but the underlying mechanism largely unknown. Here we showed upregulation associated with poor outcomes pancreatic cancer patients and suppression inhibits proliferation. We further regulates lncRNA DANCR. Ectopic expression enhances, whereas knockdown (KD) or knockout (KO) suppresses DANCR...
Cancer cell survival, function and fate strongly depend on endoplasmic reticulum (ER) proteostasis. Although previous studies have implicated the ER stress signaling network in all stages of cancer development, its role metastasis remains to be elucidated. In this study, we investigated Gremlin-1 (GREM1), a secreted protein, invasion colorectal (CRC) cells vitro vivo. Firstly, public datasets showed positive correlation between high expression GREM1 poor prognosis for CRC. Secondly, enhanced...
Abstract Background Chemoresistance presents a significant obstacle in the treatment of colorectal cancer (CRC), yet molecular basis underlying CRC chemoresistance remains poorly understood, impeding development new therapeutic interventions. Elongation factor Tu GTP binding domain containing 2 (EFTUD2) has emerged as potential oncogenic implicated various types, where it fosters tumor growth and survival. However, its specific role modulating sensitivity cells to chemotherapy is still...
Abstract Selective estrogen receptor modulators (SERMs) such as tamoxifen have proven to be effective in the treatment of (ER) positive breast cancer. However, a major obstacle for endocrine therapy is independent growth, leading resistance, and underlying mechanism not fully understood. The purpose this study was determine whether long non-coding RNAs (lncRNAs) are involved regulation growth resistance ER Using CRISPR/Cas9-based SAM (synergistic activation mediator) library against focus...
Gastrodia elata Blume (G. elata) is a valuable traditional Chinese medicine with neuroprotection, anti-inflammatory, and immune regulatory functions. MicroRNAs (miRNA) kind of endogenous noncoding small RNAs that plays distinctly important roles for gene regulation organisms. So far, the research on G. mainly focused pharmacological functions natural chemical ingredients, function miRNA remains unknown. In this study, 5,718 known miRNAs 38 novel were identified by high-throughput sequencing...
Although most gastrointestinal tumours are sensitive to 5-fluorouracil (5FU), drug resistance is commonly occurred after 5FU therapy in gastric cancer (GC). Loganetin the primary active compound Cornus officinali. However, synergetic effects of loganetin and on GC remain unknown. Here, we investigated underlying mechanism proliferation, stem-like properties, migration, invasion both vitro vivo. We found that alone inhibited migration cells vitro. Importantly, remarkably enhanced anti-cancer...
With the increase of treatment course, resistance to EGFR blockade is inevitable in patients with metastatic colorectal cancer (mCRC). KRAS mutations have been considered be primary drivers this resistance; however, potential function other genes has not extensively investigated. This study collected 17 plasma samples from mCRC cetuximab resistance, and target-capture deep sequencing was used identify circulating tumor DNA (ctDNA). Analysis mutational prevalence ctDNA performed three...
Alpha-tubulin N-acetyltransferase 1 (ATAT1) is an acetyltransferase specific to α-tubulin and performs important functions in many cellular processes. Bombyx mori economic insect also known as a model lepidoptera insect. In this study, we cloned B. ATAT1 gene (BmATAT1) (Gen Bank accession number: XP_004932777.1). BmATAT1 contained open reading frame (ORF) of 1,065 bp encoding 355 amino acids (aa). Expression profiling protein showed that the expression levels at different developmental...
<div>Abstract<p>With the increase of treatment course, resistance to EGFR blockade is inevitable in patients with metastatic colorectal cancer (mCRC). <i>KRAS</i> mutations have been considered be primary drivers this resistance; however, potential function other genes has not extensively investigated. This study collected 17 plasma samples from mCRC cetuximab resistance, and target-capture deep sequencing was used identify circulating tumor DNA (ctDNA). Analysis...
<p>Figure S1, Table S2</p>
<p>Figure S1, Table S2</p>
Abstract Background Chemoresistance remains the primary cause of mortality in colorectal cancer (CRC). However, our understanding molecular basis underlying CRC chemoresistance is still limited. Elongation factor Tu GTP binding domain containing 2 (EFTUD2) has been implicated as a potential oncogenic various types, yet its specific role regulating sensitivity cells to chemotherapy unclear. Methods Public datasets analysis, along with in-house sample validation were conducted identify...
GREMLIN1 (GREM1) is a secreted protein that antagonizes bone morphogenetic proteins (BMPs). While abnormal GREM1 expression has been reported to cause behavioral defects in postpartum mice, the spatial and cellular distribution of brain influence GREM1-secreting cells on function behavior remain unclear. To address this, we designed genetic cassette incorporating 3×Flag-TeV-HA-T2A-tdTomato sequence, resulting creation novel Grem1Tag mouse model, expressing an epitope tag (3×Flag-TeV-HA-T2A)...
<div>Abstract<p>With the increase of treatment course, resistance to EGFR blockade is inevitable in patients with metastatic colorectal cancer (mCRC). <i>KRAS</i> mutations have been considered be primary drivers this resistance; however, potential function other genes has not extensively investigated. This study collected 17 plasma samples from mCRC cetuximab resistance, and target-capture deep sequencing was used identify circulating tumor DNA (ctDNA). Analysis...
Background: With the increase of treatment course, acquired resistance epidermal growth factor receptor (EGFR)blockade is inevitable in patients with metastatic colorectal cancer (mCRC). KRAS mutations have been considered to be primary drivers this resistance; however, potential function other genes has not extensively investigated. Methods: This study included 17 mCRC cetuximab resistance, and circulating tumor DNA (ctDNA) from plasma samples were identified using target-capture deep...