Jia Chen

ORCID: 0000-0002-2216-4829
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About
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Research Areas
  • Luminescence and Fluorescent Materials
  • Nanoplatforms for cancer theranostics
  • Plasma and Flow Control in Aerodynamics
  • Advanced biosensing and bioanalysis techniques
  • Microstructure and Mechanical Properties of Steels
  • Aluminum Alloy Microstructure Properties
  • Geochemistry and Geochronology of Asian Mineral Deposits
  • Computational Fluid Dynamics and Aerodynamics
  • Advanced Photocatalysis Techniques
  • Electrocatalysts for Energy Conversion
  • Integrated Circuits and Semiconductor Failure Analysis
  • Heat Transfer and Optimization
  • Fluid Dynamics and Turbulent Flows
  • Fatigue and fracture mechanics
  • Silicon and Solar Cell Technologies
  • Recycling and Waste Management Techniques
  • Antimicrobial agents and applications
  • Neural Networks and Reservoir Computing
  • Mass Spectrometry Techniques and Applications
  • Conducting polymers and applications
  • Advanced Welding Techniques Analysis
  • Transportation Safety and Impact Analysis
  • CO2 Reduction Techniques and Catalysts
  • Advanced battery technologies research
  • Electromagnetic Launch and Propulsion Technology

UNSW Sydney
2021-2025

Sun Yat-sen University
2024

The Seventh Affiliated Hospital of Sun Yat-sen University
2024

Westlake University
2024

Dalian University of Technology
2018-2023

Chengdu Medical College
2022

University of Macau
2021-2022

Nanjing University of Posts and Telecommunications
2014-2021

Fujian Agriculture and Forestry University
2021

China Academy of Chinese Medical Sciences
2021

Aggregation-induced emission (AIE) based fluorophores (AIEgens) have attracted increasing attention for biomedical applications due to their unique optical properties. Here we report an AIE photosensitizer functionalized CB[7], namely AIECB[7], which could spontaneously self-assemble into nanoaggregates in aqueous solutions. Interestingly, the carbonyl-lace of CB[7] may potentially act as a proton acceptor acidic environment fine-tune fluorescence and singlet oxygen generation AIECB[7] by...

10.1039/d1sc01139a article EN cc-by-nc Chemical Science 2021-01-01

Abstract Carbon‐supported platinum intermetallic compound nanoparticles are seen as the next‐generation cathodic catalysts for hydrogen fuel cells due to their high activity and stability. However, synthesis faces challenges from a large diffusion barrier atom ordering, leading limited oxygen reduction performance. Understanding formation mechanisms during is crucial material design device‐level validation, which remains challenge. Herein, copper‐induced ordering reported reconstruction of...

10.1002/adfm.202501610 article EN cc-by-nc Advanced Functional Materials 2025-03-20

Water-soluble conjugated oligoelectrolyte nanoparticles (COE NPs), consisting of a cage-like polyhedral oligomeric silsesquioxanes (POSS) core equipped at each end with pendant groups (oligo(p-phenylenevinylene) electrolyte, OPVE), have been designed and demonstrated as an efficient strategy in increasing the current generation Escherichia coli microbial fuel cells (MFCs). The as-prepared COE NPs take advantage structure POSS optical properties groups, OPVE. Confocal laser scanning...

10.1021/acsami.5b03990 article EN ACS Applied Materials & Interfaces 2015-06-16

Cationic quaternary ammonium (QA) groups and reactive oxygen species as two main approaches for antibacterial study have been intensively studied. Herein, we report a multifunctional antimicrobial agent (porphyrin–POSS–OPVE, PPO), which combines bacterial membrane intercalation, high density of local QA groups, efficient energy transfer, significantly reduced aggregation, water solubility into one single molecule. The light-harvesting PPO contains multiple donor-absorbing arms...

10.1021/acsami.8b09185 article EN ACS Applied Materials & Interfaces 2018-09-13

A three-dimensional POSS-based BODIPY photosensitizer was designed for the enhanced synergistic NIR-absorbed PDT/PTT therapy.

10.1039/d0bm01863e article EN Biomaterials Science 2021-01-01

Recently, photodynamic therapy (PDT) has attracted significant attention as a minimally invasive approach for cancer treatment. Clinical applications of current photosensitizers are often limited by their poor water solubility, low singlet oxygen (1O2) quantum yields, long-term toxicity, instability, and complex nanostructures. Here, we report rational design polyhedral oligomeric silsesquioxanes (POSSs)-based porphyrin (PPP5000) used an intrinsically nanoscale photosensitizer. In this...

10.1021/acsami.7b15581 article EN ACS Applied Materials & Interfaces 2017-12-15

Inflammation is one of the most common pathological processes involved in numerous diseases. Thus, bioimaging inflammation great significance for diagnosis and treatment a variety inflammatory Herein, first time, we report supramolecular luminol–AIEgen nanoparticle (SLA NP)-based bioluminescent probe deep-tissue-inflammation imaging. SLA NPs were facilely fabricated by anchoring adamantane–luminol (AdLum) onto derived from AIEgen–cucurbit[7]uril (AIECB[7]) via CB[7]–Ad host–guest...

10.1021/acsanm.1c04420 article EN ACS Applied Nano Materials 2022-02-09

Abstract In catalysis by metalloenzymes and in electrocatalysis clusters related structure composition to the active components of such enzymes transition‐metal atoms can play a central role catalyzed redox reactions. Changes their oxidation states (OSs) are critical for understanding The OS is local property we introduce new, generally useful method determining OSs, changes, associated bonding changes electron flow. based on computing optimally localized orbitals (OLOs). With this method,...

10.1002/chem.201101916 article EN Chemistry - A European Journal 2011-09-09

Abstract Background Chemoresistance presents a significant obstacle in the treatment of colorectal cancer (CRC), yet molecular basis underlying CRC chemoresistance remains poorly understood, impeding development new therapeutic interventions. Elongation factor Tu GTP binding domain containing 2 (EFTUD2) has emerged as potential oncogenic implicated various types, where it fosters tumor growth and survival. However, its specific role modulating sensitivity cells to chemotherapy is still...

10.1186/s13046-023-02873-0 article EN cc-by Journal of Experimental & Clinical Cancer Research 2024-01-02

A facile and efficient strategy to prepare multicolor surface-functionalizable conjugated polymer nanoparticles (PPVseg-COOH CPNs) was demonstrated. The CPNs with tunable photoluminescence colors carboxylate groups were further covalently modified a series of specific molecules such as streptavidin, IgG poly(ethylene glycol) show their generality for subsequent bioconjugation biological applications. streptavidin coating can significantly improve the photostability PPVseg-SA CPNs, which...

10.1021/am503004z article EN ACS Applied Materials & Interfaces 2014-06-25

A novel cascade amplification strategy that combines the molecular wire effects of CPEs with signal capability HCR has been developed for sensitive DNA detection.

10.1039/c6ra25882d article EN cc-by-nc RSC Advances 2017-01-01

In this paper, a novel ratiometric and cascade amplification strategy was developed by combining the unique signal effective fluorescence resonance energy transfer (FRET) property of conjugated polymers with Exo III-assisted target recycling method. The DNA (ssDNAc) could be hybridized duplex-stranded probe to trigger cyclic digestion strands lead continuous release fluorescein from probe. proposed thus shows enhanced sensitivity toward detection limit 0.38 nM, which is more sensitive than...

10.1039/c8an01024b article EN The Analyst 2018-01-01

Silicon wafer solar cells with an aluminum local back surface field (Al-LBSF) are currently intensively investigated for industrial application. One of the main challenges Al-LBSF cell is formation Al rear contacts. In our previous work, we have introduced relative photoluminescence (PL) intensity method to study Al-Si contact formation. this study, apply experimentally investigate impact geometry (lines or points) contacts and compare experimental results theoretical that obtained using...

10.1109/jphotov.2013.2239701 article EN IEEE Journal of Photovoltaics 2013-01-31

Abstract n ‐type silicon wafer solar cells are receiving increasing attention for industrial application in recent years, such as the rear‐junction Passivated Emitter Rear Totally‐diffused (PERT) cells. One of main challenges fabricating ‐PERT is opening rear dielectric localized contacts. In this work laser ablation applied to locally ablate dielectric. We investigate damage emitter at laser‐ablated regions using saturation current density, J 0e , extracted by two approaches. observed be...

10.1002/pip.2604 article EN Progress in Photovoltaics Research and Applications 2015-03-05

A novel amphiphilic supramolecular solvent (SUPRAS) was developed through the hexafluoroisopropanol (HFIP)-induced self-assembly of 1,2-hexanediol in aqueous matrix. Its application potential multiclass determination assessed by extracting ten prohibited hormones and metabolic modulators (log P from 2.38 to 7.57) listed World Anti-Doping Agency (WADA) human urine. This SUPRAS can be stably formed across a wide pH range (2-12) unaffected salt concentrations (<10% g mL-1 NaCl), has higher...

10.2139/ssrn.4723929 preprint EN 2024-01-01

A computational study performed for a canard guided spin stabilized projectile using finite volume TVD schemes is described in this paper. Computational Fluid Dynamics (CFD) modeling and analysis of the spinning with fixed are conducted to determine lateral-directional aerodynamic coefficients at three supersonic speeds various angles attack. The analyses provide detailed understanding effects different circumferential position on coefficients, results show that side force coefficient yaw...

10.4028/www.scientific.net/amm.110-116.4343 article EN Applied Mechanics and Materials 2011-10-24
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