The targeted delivery of therapeutics to sites rheumatoid arthritis (RA) has been a long-standing challenge. Inspired by the intrinsic inflammation-targeting capacity macrophages, macrophage-derived microvesicle (MMV)-coated nanoparticle (MNP) was developed for targeting RA. MMV efficiently produced through novel method. Cytochalasin B (CB) applied relax interaction between cytoskeleton and membrane thus stimulating secretion. proteomic profile analyzed iTRAQ (isobaric tags relative absolute...

Rheumatoid arthritis (RA) is a chronic, systemic, progressive autoimmune disease. The vascular permeability of inflamed joints in RA makes it natural candidate for passive targeting, similar to the enhanced and retention (EPR) effect solid tumors. Thus, various therapeutic drugs have been encapsulated nanocarriers achieve longer vivo circulation times improve targeting. Although liposomes are most widely used treatment, effects physical chemical characteristics liposomes, such as particle...

Inhibition of tumor growth and normalization immune responses in the microenvironment (TME) are critical issues for improving cancer therapy. However, treatment glioma, effective nanomedicine has limited access to brain because blood-brain barrier (BBB). Previously, we demonstrated nano-sized ginseng-derived exosome-like nanoparticles (GENs) consisting phospholipids including various bioactive components, evaluated anti-tumor T cells Tregs inhibit progression. It was found that enhanced...

Inherent or acquired resistance to paclitaxel (PTX) is a pivotal challenge for chemotherapy treatment of multidrug-resistant (MDR) breast cancer. Although various targeted drug-delivery systems, including nanoparticles and liposomes, are effective MDR cancer treatment, their efficacy restricted by immunosuppressive tumor microenvironment (TME).Ginsenosides Rg3 was used formulate unique Rg3-based liposomes loaded with PTX establish Rg3-PTX-LPs, which were prepared the thin-film hydration...

Abstract Cardiac arrest (CA) is one of the most common illnesses worldwide. Post-CA brain injury (PCABI) a major cause death and poor recovery in CA patients current treatments are not very effective. The microbiome-gut-brain axis has been found to significantly affect ischemia injury. Furthermore, ischemic stroke patients, short-chain fatty acids (SCFA), especially sodium butyrate (SB), have observed promote neuroprotective effects by modulating inflammatory response microglial polarization...

The clinical treatment of gastric cancer (GC) is hampered by the development anticancer drug resistance and unfavorable pharmacokinetics, off-target toxicity, inadequate intratumoral accumulation current chemotherapy treatments. Ginsenosides combined with paclitaxel (PTX) have been shown to exert synergistic inhibition human GC cell proliferation. In present study, we developed a novel multifunctional liposome system, in which ginsenosides functioned as adjuvant membrane stabilizer. These...

Glioma remains difficult to treat because of the infiltrative growth tumor cells and their resistance standard therapy. Despite rapid development targeted drug delivery system, current therapeutic efficacy is still challenging. Based on our previous studies, macrophages have been proved be promising carrier for active glioma delivery. To make full use macrophage carrier, primary M1 were proposed replace regular deliver nanodrugs into glioma, not only natural ability home tissues, but they...

Ginseng has been used worldwide as traditional medicine for thousands of years, and ginsenosides have proved to be the main active components their various pharmacological activities. Based on structures, can divided into ginseng diol-type A triol-type B with different effects. In this study, six ginsenosides, namely ginsenoside Rb1, Rh2, Rg3, Rg5 saponins, Rg1 Re which were reported effective ischemia-reperfusion (I/R) treatment, chosen compare protective effects cerebral I/R injury,...

Abstract Liposomes hold great potential in anti-cancer drug delivery and the targeting treatment of tumors. However, clinical therapeutic efficacy liposomes is still limited by complexity tumor microenvironment (TME) insufficient accumulation sites. Meanwhile, application cholesterol polyethylene glycol (PEG), which are usually used to prolong blood circulation stabilize structure respectively, has been questioned due various disadvantages. Herein, we developed a ginsenoside Rh2-based...

Oxidative stress, nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and adenosine signaling are factors associated with psoriatic inflammation. Topical delivery methotrexate (MTX) has become an option to overcome the side effects caused by systemic therapy in psoriasis, leading suppression NF-κB activation through boosting release. However, thickened skin is primary restriction against local drug delivery.In this study, a ROS responsive MTX prodrug (MTX-TK-HA) was...

Cisplatin, as the first-line anti-tumor agent, is widely used for treatment of a variety malignancies including non-small cell lung cancer (NSCLC). However, acquired resistance has been major obstacle clinical application. Scutellarin active flavone extracted from Erigeron breviscapus Hand-Mazz that shown to exhibit anticancer activities on various types tumors. Here, we reported scutellarin was capable sensitizing A549/DDP cells cisplatin by enhancing apoptosis and autophagy. Mechanistic...

Chemotherapy outcomes for the treatment of glioma remains unsatisfactory due to inefficient drug transport across blood-brain barrier (BBB) and insufficient accumulation in tumor region. Although many approaches, including various nanosystems, have been developed promote distribution chemotherapeutics brain tumor, delivery efficiency possible damage normal function still greatly restrict clinical application nanocarriers. Therefore, it is urgent necessary discover more safe effective BBB...

Cisplatin remains the standard first-line chemotherapeutic agent in treatment of many types cancers, but its clinical application is hindered by severe nephrotoxicity. Previous studies reported that scutellarin enhanced anti-cancer activity cisplatin lung cancer cells, with no confirmation on cisplatin-induced renal damage. Here, we investigated nephroprotective effect injury and underlying mechanisms. Renal function, histological change, inflammation, apoptosis, autophagy involved pathways...

The chemotherapy effect of docetaxel (DTX) against triple-negative breast cancer (TNBC) remains mediocre and limited when encapsulated in conventional cholesterol liposomes, mainly ascribed to poor penetration immunosuppressive tumor microenvironment (TME) caused by stroma cells, especially cancer-associated fibroblasts (CAFs). Many studies have attempted address these problems but trapped into the common dilemma excessively complicated formulation strategies at expense druggability as well...

The unsatisfactory therapeutic outcome for glioma is mainly due to the poor blood–brain barrier (BBB) permeability and inefficient accumulation in area of chemotherapeutic agents. existing drug delivery strategies can increase transport brain but are restricted by side effects and/or efficiency. In this study, potent penetration enhancers were screened from active components aromatic resuscitation drugs used traditional Chinese medicine. A novel glioma-targeting system based on...

To utilize the multiple functions and give full play of ginsenosides, a variety ginsenosides with different structures were prepared into liposomes evaluated for their effect on stability, pharmacokinetics tumor targeting capability liposomes. The results showed that position number glycosyl groups have significant in vitro vivo properties indicated C-3 sugar group is beneficial to longer circulation vivo. C-6 glycosyls can enhance uptake by 4T1 cells, at active ability significantly, based...

Background: Most solid tumors are not diagnosed and treated until the advanced stage, in which have shaped mature self-protective power, leading to off-target drugs nanomedicines. In present studies, we established a more realistic large tumor model test antitumor activity of multifunctional ginsenoside Rh2-based liposome system (Rh2-lipo) on breast cancer. Methods: Both cholesterol PEG were substituted by Rh2 prepare Rh2-lipo using ethanol-water characterized. The effects cell uptake,...

Curative molecular therapy for non-small cell lung cancer (NSCLC) is still lacking.Scutellarin, an active flavone extracted from Erigeron breviscapus Hand-Mazz, displays anti-tumor property in diverse types, yet its tumor-suppressive effect on NSCLC not reported.In this study, we found that scutellarin significantly inhibited the proliferation of cells, induced apoptosis, and triggered autophagy.Notably, inhibition autophagy with inhibitor HCQ attenuated anti-proliferative activity...

Abstract Current chemotherapeutics for glioma are not sufficiently effective due to their low tolerance and poor blood–brain barrier (BBB) permeability. Energy restriction based on co-delivery of albendazole (Abz) nano-silver has been proven suppress tumor growth without adverse effects. Accordingly, menthol was conjugated BSA (MeB) overcome the BBB-permeability issue. In this study, Abz-loaded MeB-silver nanoparticles (MBS-Abz) were developed by self-assembly MeB, nano silver targeting...

Based on amino acid metabolism-related genes (AAMRGs), this study aimed at screening out key prognosis-related and finding the underlying correlation between metabolism tumor immune microenvironment of colorectal cancer. A total 448 were obtained from MsigDB. The risk signature was built based differential expression genes, univariate Cox, LASSO analyses with 403 patients' data downloaded TCGA database. Survival analysis independence tests performed to confirm validity signature....

Dehydroepiandrosterone (DHEA) may be a promising agent for postmenopausal osteoporosis (PMO), but its mechanism to modulate osteoblasts (OBs) is yet explained. To elucidate the effects of DHEA treatment on ovariectomized (OVX) mice and mechanisms, we evaluated morphology bone tissue expression proliferating cell nuclear antigen (PCNA) in vertebrae-derived OB after having treated OVX animals with DHEA. The results showed that administration increased PCNA changed morphometry PMO model....