A5100461704- Cytokine Signaling Pathways and Interactions
- MicroRNA in disease regulation
- interferon and immune responses
- Atherosclerosis and Cardiovascular Diseases
- Cell Adhesion Molecules Research
- Psoriasis: Treatment and Pathogenesis
- Digestive system and related health
- Cancer-related molecular mechanisms research
- Helicobacter pylori-related gastroenterology studies
- IL-33, ST2, and ILC Pathways
Shandong Provincial Hospital
2020
University of Wisconsin–Madison
2019
Guangzhou University of Chinese Medicine
2018
Hubei University of Arts and Science
2014
Central South University
2013
University of North Carolina at Chapel Hill
2005
Regeneration of denuded or injured endothelium is an important component vascular injury response. Cell-cell communication between endothelial cells and smooth muscle (SMCs) plays a critical role not only in homeostasis but also disease. We have previously demonstrated that PKCδ (protein kinase C-delta) regulates multiple components response including apoptosis SMCs production chemokines, thus attractive candidate for SMC-endothelial communication.To test whether PKCδ-mediated paracrine...
Abstract Psoriasis is a common chronic skin disease characterized by epidermal hyperplasia and inflammation. However, the pathogenesis of psoriasis multifactorial not fully understood. MicroRNAs (miRNAs) represent promising class small, noncoding RNA molecules that have large impact on cellular functions regulating gene expression. Here we reported microRNA‐187 (miR‐187), which one most dynamic microRNAs identified in deep screening miRNAs profile, downregulated inflammatory...
Abstract Background Osteosarcoma (OS) is the most common childhood bone cancer. Chemoresistance principal reason for poor survival and disease recurrence in OS patients, ET‐1 reportedly plays an important role development of chemoresistance cells. In present study, we first time explored association endothelin‐1 (ET‐1) SNPs haplotypes with risk chemoresistant pediatric OS. Procedure We genotyped three (rs1800541, rs2070699, rs5370) gene a case–control using 350 pairs age, sex, tumor location...
Abstract Objectives To explore the roles of miR‐1193/Janus kinase 3 (JAK3) axis and potential mechanism in rheumatoid arthritis (RA). Methods The dysregulated genes microRNAs (miRNAs) were screened using datasets GSE12021 GSE72564 , while upstream miRNA JAK3 was forecasted by TargetScan. Then MH7A cells treated with interleukin‐1β (IL‐1β) to induce local inflammation. Double luciferase report assay used estimate association between miR‐1193. Flow cytometry 3‐[4,5‐dimethylthiazol‐2‐yl]‐2,5...