A5000603446- Aortic aneurysm repair treatments
- Atherosclerosis and Cardiovascular Diseases
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Immune cells in cancer
- Angiogenesis and VEGF in Cancer
- Phagocytosis and Immune Regulation
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Cell Adhesion Molecules Research
- MicroRNA in disease regulation
- Neurofibromatosis and Schwannoma Cases
- Ferroptosis and cancer prognosis
- Aortic Disease and Treatment Approaches
- Extracellular vesicles in disease
- Infectious Aortic and Vascular Conditions
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Glioma Diagnosis and Treatment
- Ubiquitin and proteasome pathways
- RNA Interference and Gene Delivery
- Hepatitis C virus research
- Polymer Surface Interaction Studies
- Ocular Infections and Treatments
- Cell death mechanisms and regulation
- Reproductive Health and Technologies
Yangzhou University
2025
Northern Jiangsu People's Hospital
2025
Massachusetts General Hospital
2018-2025
Harvard University
2018-2025
Shuguang Hospital
2023-2024
Shanghai University of Traditional Chinese Medicine
2022-2024
Hainan Normal University
2024
Quzhou University
2024
University of Electronic Science and Technology of China
2024
Eye & ENT Hospital of Fudan University
2022-2024
Cardiovascular disease is the leading cause of mortality worldwide. Atherosclerosis, one most common forms disease, characterized by a gradual formation atherosclerotic plaque, hardening, and narrowing arteries. Nanomaterials can serve as powerful delivery platforms for atherosclerosis treatment. However, their therapeutic efficacy substantially limited in vivo due to nonspecific clearance mononuclear phagocytic system. In order address this limitation, rapamycin (RAP)-loaded poly(lactic-
Abstract Immune checkpoint blockers (ICBs) have failed in all phase III glioblastoma (GBM) trials. Here, we show that regulatory T (Treg) cells play a key role GBM resistance to ICBs experimental gliomas. Targeting glucocorticoid-induced TNFR-related receptor (GITR) Treg using an agonistic antibody (αGITR) promotes CD4 cell differentiation into effector cells, alleviates cell-mediated suppression of anti-tumor immune response, and induces potent GBM. The reprogrammed GBM-infiltrating express...
Chimeric antigen receptor (CAR)-T cells have revolutionized the treatment of multiple types hematological malignancies, but shown limited efficacy in patients with glioblastoma (GBM) or other solid tumors. This may be largely due to immunosuppressive tumor microenvironment (TME) that compromises CAR-T cells’ delivery and antitumor activity. We previously showed blocking vascular endothelial growth factor (VEGF) signaling can normalize vessels murine human tumors, including GBM, breast,...
Histological examination of abdominal aortic aneurysm (AAA) tissues demonstrates extracellular matrix destruction and infiltration inflammatory cells. Previous work with mouse models AAA has shown that anti-inflammatory strategies can effectively attenuate formation. Thrombospondin-1 is a matricellular protein involved in the maintenance vascular structure homeostasis through regulation biological functions, such as cell proliferation, apoptosis, adhesion. Expression levels thrombospondin-1...
Rationale: Depletion of medial smooth muscle cell (SMC) is a major pathological characteristic abdominal aortic aneurysm (AAA), although the mechanism by which these cells are eliminated remains incompletely understood. We reasoned that necroptosis, recently described form necrosis mediated receptor-interacting protein kinase 3 (RIP3), may contribute to AAA pathology through induction SMC death and significant production inflammatory cytokines. Objective: To test hypothesis RIP3-mediated...
Abstract Receptor interacting protein kinase-1 and -3 (RIP1 RIP3) are essential mediators of cell death processes participate in inflammatory responses. Our group recently demonstrated that gene deletion Rip3 or pharmacological inhibition RIP1 attenuated pathogenesis abdominal aortic aneurysm (AAA), a life-threatening degenerative vascular disease characterized by depletion smooth muscle cells (SMCs), inflammation, negative extracellular matrix remodeling, progressive expansion aorta. The...
Liver metastasis is a major cause of mortality for patients with colorectal cancer (CRC). Mismatch repair-proficient (pMMR) CRCs make up about 95% metastatic CRCs, and are unresponsive to immune checkpoint blockade (ICB) therapy. Here we show that mouse models orthotopic pMMR CRC liver accurately recapitulate the inefficacy ICB therapy in patients, whereas same tumors sensitive when grown subcutaneously. To reveal local, nonmalignant components determine sensitivity treatment, compared...
Summary Host immune responses must be tightly regulated by an intricate balance between positive and negative signals while fighting pathogens; persistent pathogens may usurp these regulatory mechanisms to dampen host immunity facilitate survival in vivo . Here we report that T im‐3, a signalling molecule expressed on monocytes cells, is up‐regulated natural killer ( NK ) cells individuals chronically infected with hepatitis C virus HCV ). Additionally, the transcription factor ‐bet was also...
Aims In abdominal aortic aneurysm (AAA), macrophages are detected in the proximity of smooth muscle cells (SMCs). We have previously demonstrated a murine model AAA that apoptotic SMCs attract monocytes and other leukocytes by producing MCP-1. Here we tested whether infiltrating also directly contribute to SMC apoptosis. Methods Results Using SMC/RAW264.7 macrophage co-culture system, MCP-1-primed RAWs caused significantly higher level apoptosis as compared control macrophages. Next, an...
Objective: Regulatory T cells (Tregs) contribute to HIV-1 disease progression by impairing antiviral immunity; however, the precise mechanisms responsible for development of Tregs in setting infection are incompletely understood. Design: In this study, we provide evidence that HIV-induced expansion monocytic myeloid-derived suppressor (M-MDSCs) promote differentiation Foxp3+ Tregs. Methods: We measured MDSC induction and cytokine expression flow cytometry analyzed their functions coculturing...
Abstract Abdominal aortic aneurysm (AAA) is a common disease with progressive nature. There no approved pharmacological treatment to effectively slow growth or prevent rupture. Necroptosis form of programmed necrosis that regulated by receptor-interacting protein kinases (RIPs). We have recently demonstrated the lack RIP3 in mice prevented formation. The goal current study test whether perturbing necroptosis affects progression existing using RIP1 inhibitors Necrostatin-1 (Nec-1) and an...
Summary T cells play a pivotal role in controlling viral infection; however, the precise mechanisms responsible for regulating T‐cell differentiation and function during infections are incompletely understood. In this study, we demonstrated an expansion of myeloid‐derived suppressor ( MDSC s), particular monocytic s (M‐ s; CD 14 + 33 11b HLA ‐ DR −/low ), patients with chronic hepatitis C virus HCV ) infection. Notably, ‐induced M‐ express high levels phosphorylated signal transducer...
Normalizing the tumor microenvironment with losartan prevents tumor-induced hearing loss and enhances radiation response in schwannoma rodent models.
Local neuroinflammation secondary to spinal nerve compression in lumbar disk herniation (LDH) is a key driver contributing neuropathic pain. Manual therapy (MT), widely used nonsurgical therapy, can relieve LDH-mediated pain by reducing inflammation. MT has attracted extensive attention; however, its mechanism remains poorly understood. MicroRNAs (miRNAs) are important regulators of signaling transduction, but rarely reported the chronic dorsal root ganglia (CCD) model, and further...
Ependymoma (EPN) is a common form of brain tumor in children, often resistant to available cytotoxic therapies. Molecular profiling studies have led better understanding EPN subtypes and revealed critical role oncogenes ZFTA–RELA fusion EPHB2 supratentorial ependymoma (ST-EPN). However, the immune system’s progression response therapy remains poorly understood. New treatments for various molecular are desperately needed. Using ST-EPN-ZFTA subtype-specific syngeneic mouse models, we found an...
Coinfection of hepatitis B virus (HBV) with C (HCV) is quite common, leading to an increase in morbidity and mortality. As such, HBV vaccination recommended HCV-infected individuals. However, vaccine responses individuals are often blunted compared uninfected populations. The mechanism for this failure response subjects remains unclear. In study, we investigated the expression function inhibitory receptor, killer cell lectin-like receptor subfamily G member 1 (KLRG1), regulation CD4(+) T...
T cells play a crucial role in viral clearance or persistence; however, the precise mechanisms that control their responses during infection remain incompletely understood. MicroRNA (miR) has been implicated as key regulator controlling diverse biological processes through posttranscriptional repression. Here, we demonstrate hepatitis C virus (HCV)–mediated decline of miR‐181a expression impairs CD4 + T‐cell overexpression dual specific phosphatase 6 (DUSP6). Specifically, significant along...
The adventitia is increasingly recognized as an important player during the development of intimal hyperplasia. However, mechanism adventitial cell recruitment to subintimal space remains largely undefined. We have shown previously that gene transfer protein kinase C-delta (PKCδ) increases apoptosis smooth muscle cells following balloon injury. In current study, we investigated a potential role PKCδ in regulating cells.Conditioned media from PKCδ-overexpressing stimulated migration and CCR2...
Regeneration of denuded or injured endothelium is an important component vascular injury response. Cell-cell communication between endothelial cells and smooth muscle (SMCs) plays a critical role not only in homeostasis but also disease. We have previously demonstrated that PKCδ (protein kinase C-delta) regulates multiple components response including apoptosis SMCs production chemokines, thus attractive candidate for SMC-endothelial communication.To test whether PKCδ-mediated paracrine...