A5021812533- Cellular Mechanics and Interactions
- Osteoarthritis Treatment and Mechanisms
- Cancer, Lipids, and Metabolism
- Pancreatic and Hepatic Oncology Research
- 3D Printing in Biomedical Research
- Force Microscopy Techniques and Applications
- Cell Adhesion Molecules Research
- Inhalation and Respiratory Drug Delivery
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cancer Cells and Metastasis
- Cancer, Stress, Anesthesia, and Immune Response
- Lower Extremity Biomechanics and Pathologies
- Lubricants and Their Additives
- Glioma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Microfluidic and Bio-sensing Technologies
- Proteoglycans and glycosaminoglycans research
- Elasticity and Material Modeling
- Adipokines, Inflammation, and Metabolic Diseases
- Robotic Mechanisms and Dynamics
- Angiogenesis and VEGF in Cancer
- Silk-based biomaterials and applications
- Microtubule and mitosis dynamics
- Connective tissue disorders research
- Tendon Structure and Treatment
Boston University
2019-2025
Massachusetts General Hospital
2016-2021
Harvard University
2016-2020
MGH Institute of Health Professions
2017
Massachusetts Institute of Technology
2011-2015
Harvard University Press
2015
Sharif University of Technology
2005-2007
It remains unclear how obesity worsens treatment outcomes in patients with pancreatic ductal adenocarcinoma (PDAC). In normal pancreas, promotes inflammation and fibrosis. We found mouse models of PDAC that also desmoplasia associated accelerated tumor growth impaired delivery/efficacy chemotherapeutics through reduced perfusion. Genetic pharmacologic inhibition angiotensin-II type-1 receptor reverses obesity-augmented improves response to chemotherapy. Augmented activation stellate cells...
Anti-VEGF therapy enhances mechanical barriers to in colorectal cancer liver metastases by increasing hyaluronan deposition.
Significance Despite initial responsiveness to chemotherapy, the overwhelming majority of advanced ovarian cancer patients relapse with resistant disease. Thus, developing more effective strategies for treatment is a high clinical priority. Here, we report that targeting angiotensin signaling losartan, an receptor blocker, can reduce extracellular matrix in tumors and associated physical barriers normally hinder drug delivery efficacy. These changes tumor microenvironment lead improved...
Joint biomechanical functions rely on the integrity of cartilage extracellular matrix. Understanding molecular activities that govern matrix assembly is critical for developing effective regeneration strategies. This study elucidated role decorin, a small leucine-rich proteoglycan, in structure and cartilage. In decorin-null cartilage, we discovered substantial reduction aggrecan content, major proteoglycan matrix, mild changes collagen fibril nanostructure. loss resulted significantly...
Poroelastic interactions between interstitial fluid and the extracellular matrix of connective tissues are critical to biological pathophysiological functions involving solute transport, energy dissipation, self-stiffening lubrication. However, molecular origins poroelasticity at nanoscale largely unknown. Here, broad-spectrum dynamic nanomechanical behavior cartilage aggrecan monolayer is revealed for first time, including equilibrium instantaneous moduli peak in phase angle complex...
Objective Intrahepatic cholangiocarcinoma (ICC)—a rare liver malignancy with limited therapeutic options—is characterised by aggressive progression, desmoplasia and vascular abnormalities. The aim of this study was to determine the role placental growth factor (PlGF) in ICC progression. Design We evaluated expression PlGF specimens from patients assessed effect genetic or pharmacologic inhibition orthotopically grafted mouse models. impact stimulation blockade cells cancer-associated...
The fact that acoustic radiation from a violin at air-cavity resonance is monopolar and can be determined by pure volume change used to help explain related aspects of design evolution. By determining the conductance arbitrarily shaped sound holes, it found air flow perimeter rather than broader sound-hole area dominates conductance, coupling between compressible within its elastic structure lowers Helmholtz frequency for corresponding rigid instrument roughly semitone. As result former, as...
Our objective is to provide an in-depth review of the recent technical advances atomic force microscopy (AFM)-based nanomechanical tests and their contribution a better understanding diagnosis osteoarthritis (OA), as well repair tissues undergoing degeneration during OA progression. We first summarize range approaches for AFM-based nanoindentation, including considerations in both experimental design data analysis. then more detailed description two recently developed modes...
Abstract Natural and synthetic hydrogel scaffolds exhibit distinct viscoelastic properties at various length scales deformation rates. Laser Speckle Rheology (LSR) offers a novel, non-contact optical approach for evaluating the frequency-dependent of hydrogels. In LSR, coherent laser beam illuminates specimen high-speed camera acquires time-varying speckle images. Cross-correlation analysis frames returns intensity autocorrelation function, g 2 ( t ), from which modulus, G* ω is deduced....
MEPS Marine Ecology Progress Series Contact the journal Facebook Twitter RSS Mailing List Subscribe to our mailing list via Mailchimp HomeLatest VolumeAbout JournalEditorsTheme Sections 395:137-160 (2009) - DOI: https://doi.org/10.3354/meps08266 Ocean Acoustic Waveguide Remote Sensing (OAWRS) of marine ecosystems Srinivasan Jagannathan1, Ioannis Bertsatos1, Deanelle Symonds1, Tianrun Chen1, Hadi Tavakoli Nia1, Ankita Deepak Jain1, Mark Andrews2, Zheng Gong2, Redwood Nero3,4, Lena Ngor1, Mike...
Chondroadherin (CHAD), a class IV small leucine rich proteoglycan/protein (SLRP), was hypothesized to play important roles in regulating chondrocyte signaling and cartilage homeostasis. However, its development function are not well understood, no major osteoarthritis-like phenotype found the murine model with CHAD genetically deleted (CHAD−/−). In this study, we used atomic force microscopy (AFM)-based nanoindentation quantify effects of deletion on changes biomechanical cartilage....