A5074728058- Osteoarthritis Treatment and Mechanisms
- Knee injuries and reconstruction techniques
- Cell Adhesion Molecules Research
- Cellular Mechanics and Interactions
- Proteoglycans and glycosaminoglycans research
- Tendon Structure and Treatment
- Force Microscopy Techniques and Applications
- Polymer Surface Interaction Studies
- Hydrogels: synthesis, properties, applications
- 3D Printing in Biomedical Research
- Silk-based biomaterials and applications
- Electrospun Nanofibers in Biomedical Applications
- Spine and Intervertebral Disc Pathology
- Bone Tissue Engineering Materials
- Collagen: Extraction and Characterization
- Lower Extremity Biomechanics and Pathologies
- Tissue Engineering and Regenerative Medicine
- Lubricants and Their Additives
- Polysaccharides Composition and Applications
- Inflammatory mediators and NSAID effects
- Phytochemicals and Antioxidant Activities
- Musculoskeletal pain and rehabilitation
- Advanced Sensor and Energy Harvesting Materials
- Food composition and properties
- Connective tissue disorders research
Drexel University
2016-2025
Northwest A&F University
2024-2025
Peking University
2025
Peking University People's Hospital
2025
Universidade de Vigo
2025
Dalian Polytechnic University
2023-2024
Changhai Hospital
2024
Second Military Medical University
2024
He Eye Hospital
2024
China Medical University
2024
3D microenvironmental parameters control cell behavior, but can be challenging to investigate over a wide range of conditions. Here, combinatorial hydrogel platform is developed that uses light-mediated thiol-norbornene chemistry encapsulate cells within hydrogels with biochemical gradients made by spatially varied light exposure. Specifically, mesenchymal stem are photoencapsulated in norbornene-modified hyaluronic acid functionalized (0-5 mM) peptides mimic cell-cell or cell-matrix...
EGFR activation by overexpressing HBEGF in cartilage or intra-articular delivery of TGFα nanoparticles attenuates osteoarthritis development mice.
Granular hydrogels are an emerging class of biomaterials formed by jamming hydrogel microparticles (i.e., microgels). These materials have many advantageous properties that can be tailored through microgel design and extent packing. To enhance the range properties, granular composites with a interstitial matrix between packed microgels, allowing for material flow then stabilization after crosslinking. This approach allows distinct compartments microgels space) varied to engineer complex...
Cartilage is a hydrated biomacromolecular fiber composite located at the ends of long bones that enables proper joint lubrication, articulation, loading, and energy dissipation. Degradation extracellular matrix molecular components changes in their nanoscale structure greatly influence macroscale behavior tissue result dysfunction with age, injury, diseases such as osteoarthritis. Here, application field nanomechanics to cartilage reviewed. Nanomechanics involves measurement prediction...
Applying hierarchical cuts to thin sheets of elastomer generates super-stretchable and reconfigurable metamaterials, exhibiting highly nonlinear stress–strain behaviors tunable phononic bandgaps. The cut concept fails on brittle due severe stress concentration in the rotating hinges. By engineering local hinge shapes global structure, cut-based metamaterials with largely enhanced strength are realized. As a service our authors readers, this journal provides supporting information supplied by...
Polyelectrolyte multilayer films assembled from a hydrophobic N-alkylated polyethylenimine and hydrophilic polyacrylate were discovered to exhibit strong antifouling, as well antimicrobial, activities. Surfaces coated with these layer-by-layer (LbL) films, which range 6 10 bilayers (up 45 nm in thickness), adsorbed up 20 times less protein blood plasma than the uncoated controls. The dependence of antifouling activity on nature polycation, assembly conditions number layers LbL was...
Significance The uppermost superficial zone of articular cartilage plays multifaceted roles in maintaining structure, function, and mechanical properties preventing degeneration during osteoarthritis initiation. However, its regulation by growth factors hormones is still largely unknown. Here we report that EGFR signaling an important factor pathway maintains chondrocyte number, promotes boundary lubricant secretion surface lubrication, stimulates strength cartilage. Reduction activity leads...
Precise synthesis of polymer brushes to modify the surface nanoparticles and nanodevices for targeted applications has been one major focuses in community decades. Here we report a self-assembly-assisted-grafting-to approach synthesize on flat substrates. In this method, polymers are pre-assembled into two-dimensional single crystals (PSCs) with functional groups surface. Chemically coupling PSCs onto solid substrates leads formation brushes. Exquisite control chain folding allows us obtain...
Smart window has immense potential for energy savings in architectural and vehicular applications, while most studies focus on the tunability of a single property optical transmittance. Here we explore harnessing dynamically tunable hierarchical wrinkles design multifunctional smart with combined structural color water droplet transport control. The self-similar both nanoscale microscale features are generated prestrained poly(dimethylsiloxane) elastomer through sequential strain release...
Joint biomechanical functions rely on the integrity of cartilage extracellular matrix. Understanding molecular activities that govern matrix assembly is critical for developing effective regeneration strategies. This study elucidated role decorin, a small leucine-rich proteoglycan, in structure and cartilage. In decorin-null cartilage, we discovered substantial reduction aggrecan content, major proteoglycan matrix, mild changes collagen fibril nanostructure. loss resulted significantly...
Technology of tissue-engineering advanced rapidly in the last decade and motivated numerous studies cell-engineering biofabrication. Three-dimensional (3D) scaffolds play a critical role this field, as provide biomimetic microenvironments that could stimulate desired cell behaviors for regeneration. However, despite many achievements, fabrication 3D scaffold remains challenging due to difficulty encapsulating cells scaffolds, controlling cell-cell organization 3D, being adapted by users...
Abstract Cell migration is critical for tissue development and regeneration but requires extracellular environments that are conducive to motion. Cells may actively generate migratory routes in vivo by degrading or remodeling their instead utilize existing matrix microstructures microtracks as innate pathways migration. While hydrogels general valuable tools probing the regulators of 3-dimensional migration, few recapitulate these natural paths. Here, we develop a biopolymer-based...
Colored potatoes have many health benefits because they are rich in anthocyanins. However, the constituent and property of anthocyanins colored not been systematically studied yet. Herein, metabolomic analysis was carried out to investigate chemical composition four different potatoes. After that, extract purification conditions, stability were further studied. The results indicated that contained abundant polyphenols, flavonoids, Cyanidin, delphinidin, malvidin identified as major...