A5073162662- 3D Printing in Biomedical Research
- Cellular Mechanics and Interactions
- DNA Repair Mechanisms
- Hydrogels: synthesis, properties, applications
- Effects of Radiation Exposure
- Neuroscience and Neural Engineering
- Advanced Radiotherapy Techniques
- Genomics and Rare Diseases
- Polyomavirus and related diseases
- Economic and Financial Impacts of Cancer
- Sulfur Compounds in Biology
- Redox biology and oxidative stress
- RNA Interference and Gene Delivery
- Pharmacogenetics and Drug Metabolism
- Carcinogens and Genotoxicity Assessment
- Cardiomyopathy and Myosin Studies
- Oral health in cancer treatment
- Psoriasis: Treatment and Pathogenesis
- Tissue Engineering and Regenerative Medicine
- Advancements in Transdermal Drug Delivery
- Physical Unclonable Functions (PUFs) and Hardware Security
- Micro and Nano Robotics
- Lung Cancer Treatments and Mutations
- Multiple and Secondary Primary Cancers
- Medical Imaging and Pathology Studies
University of Pennsylvania
2021-2024
Philadelphia VA Medical Center
2023-2024
University of Colorado Boulder
2024
Duke University
2023
Sichuan University
2020
West China Hospital of Sichuan University
2020
Digital China Health (China)
2019
Digital Health Cooperative Research Centre
2019
University Hospitals of Cleveland
2019
Radiation Oncology Associates
2019
Synthetic fibrous materials were engineered to contract under cellular forces similar natural extracellular matrix.
Abstract Cell migration is critical for tissue development and regeneration but requires extracellular environments that are conducive to motion. Cells may actively generate migratory routes in vivo by degrading or remodeling their instead utilize existing matrix microstructures microtracks as innate pathways migration. While hydrogels general valuable tools probing the regulators of 3-dimensional migration, few recapitulate these natural paths. Here, we develop a biopolymer-based...
Hardware security has emerged as an important field of study aimed at mitigating issues such piracy, counterfeiting, and side channel attacks. One popular solution for hardware attacks are physical unclonable functions (PUF) which provide a specific unique signature or identification. The uniqueness PUF depends on intrinsic process variations within individual integrated circuits. As become more prevalent due to technology scaling into the nanometer regime, novel nanoelectronic technologies...
Abstract Purpose The extracellular environment is critical for cell migration in three-dimensions (3D), which has been understudied when compared to on two-dimensional (2D) substrates. In 3D, cells must degrade or remodel their surroundings overcome barriers find paths that act as routes. Methods We performed a literature search studies related the engineering of hydrogels understand and control migration. Results This review highlights cell-intrinsic machinery required migration, describes...
We evaluated normal tissue specific radioprotection of the oral cavity in radiosensitive Fanconi Anemia (FA) Fancd2–/– mice with orally established tumors using mitochondrial-targeted GS-nitroxide (JP4-039). Adult (10–12 weeks old) Fancd2 / , /– and (C57BL/6 background) subgroups TC-1 epithelial cell received a single fraction 28 Gy or four daily fractions 8 to head neck. Subgroups JP4-039 F15 emulsion (F15/JP4-039; 0.4 mg/mouse), 4-amino-Tempo (F15/4-amino-Tempo; 0.2 mg/mouse) alone prior...
The altered DNA damage response pathway in patients with Fanconi anemia (FA) may increase the toxicity of clinical radiotherapy. We quantitated oral cavity mucositis irradiated Fancd2–/– mice, comparing this to Fancd2 /– and / we measured distant bone marrow suppression effect intraoral radioprotector GS-nitroxide, JP4-039 F15 emulsion. found that FA mice were more susceptible radiation injury protection from by JP4-039/F15 was observed at all doses. Adult 10–12-week-old FVB/N background...
Traditionally, the use of genomic information for personalized medical decisions relies on prior discovery and validation genotype-phenotype associations. This approach constrains care patients presenting with undescribed problems. The National Institutes Health (NIH) Undiagnosed Diseases Program (UDP) hypothesized that defining disease as maladaptation to an ecological niche allows delineation a logical framework diagnose evaluate such patients. Herein, we present philosophical bases,...
ABSTRACT The development of multicellular complex organisms relies on coordinated signaling from the microenvironment, including both biochemical and mechanical interactions. To better understand developmental biology, increasingly sophisticated in vitro systems are needed to mimic these extracellular features. In this Primer, we explore how engineered hydrogels can serve as culture platforms present such signals a controlled manner include examples they have been used advance our...
Janus kinase (JAK) inhibitors are approved for many dermatologic disorders, but their use is limited by systemic toxicities including serious cardiovascular events and malignancy. To overcome these limitations, injectable hydrogels engineered the local sustained delivery of baricitinib, a representative JAK inhibitor. Hydrogels formed via disulfide crosslinking thiolated hyaluronic acid macromers. Dynamic thioimidate bonds introduced between nitrile-containing baricitinib drug tethering,...
Extracellular vesicles (EVs) are gaining interest in regenerative medicine and biomaterials have been shown to extend EV bioavailability following delivery. Here, we report the labeling of both hydrogels EVs better understand hydrogel design for sustained release into tissues. Shear-thinning were engineered using guest-host (i.e., adamantane-cyclodextrin) modifications hyaluronic acid (GH), as well GH with addition gelatin crosslinked via transglutaminase (GH+Gel) temporally control...
Abstract Kidney explant cultures are traditionally carried out at air-liquid interfaces, which disrupts 3D tissue structure and limits interpretation of developmental data. To overcome this limitation, we developed a culture technique using hydrogel embedding to capture morphogenesis in real time. We show that better approximates vivo -like niche spacing dynamic tubule tip rearrangement, as well presentation branching defects under perturbations glial cell-derived neurotrophic factor (GDNF)-...
Abstract Fanconi Anemia (FA) patients are at risk for head and neck squamous cell carcinomas. Their normal tissue radiosensitivity often presents a challenge to deliver radiotherapy. Locally applied GS-nitroxide JP4-039 radioprotects the oral mucosa of Fancd2-/-(129/Sv) mice from single fraction or fractionated irradiation (Berhane et al, Radiation Research 182:35-49, 2014). We sought prove that targets mitochondria mucosal cells, protects in vivo, but does not prevent radiocontrolability...
The natural extracellular matrix (ECM) within tissues is physically contracted and remodeled by cells, allowing the collective shaping of functional tissue architectures. Synthetic materials that facilitate self-assembly similar to ECM are needed for cell culture, engineering, in vitro models development disease. To address this need, we develop fibrous hydrogel assemblies stabilized with photocrosslinking display fiber density dependent strain responsive properties (strain-stiffening,...
Abstract Cell migration is critical for tissue development and regeneration but requires extracellular environments that are conducive to motion. Cells may actively generate migratory routes in vivo by degrading or remodeling their instead utilize existing ECM microstructures microtracks as innate pathways migration. While hydrogels general valuable tools probing the regulators of 3D migration, few have recapitulated these natural paths. Here, we developed a biopolymer-based (i.e., gelatin...