A5040539777- Cardiac Fibrosis and Remodeling
- Cardiac Ischemia and Reperfusion
- Cardiovascular Function and Risk Factors
- Advanced MRI Techniques and Applications
- Cardiac Imaging and Diagnostics
- Metabolomics and Mass Spectrometry Studies
- Organ Transplantation Techniques and Outcomes
- Extracellular vesicles in disease
- Transplantation: Methods and Outcomes
- Mechanical Circulatory Support Devices
- Mitochondrial Function and Pathology
- RNA Interference and Gene Delivery
- Electrospun Nanofibers in Biomedical Applications
- Adipose Tissue and Metabolism
University of Pennsylvania
2023-2024
Hospital of the University of Pennsylvania
2024
Demand for donor hearts and lungs exceeds their supply. Extended Criteria Donor (ECD) organs are used to help meet this demand, but impact on heart-lung transplantation outcomes is poorly characterized.The United Network Organ Sharing was queried data adult recipients (n = 447) from 2005‒2021. Recipients were stratified based whether they received ECD and/or lungs. Morbidity analyzed using Kruskal-Wallis, chi-square, Fisher's exact tests. Mortality Kaplan-Meier estimation, log-rank tests Cox...
Extracellular vesicles (EVs) are gaining interest in regenerative medicine and biomaterials have been shown to extend EV bioavailability following delivery. Here, we report the labeling of both hydrogels EVs better understand hydrogel design for sustained release into tissues. Shear-thinning were engineered using guest-host (i.e., adamantane-cyclodextrin) modifications hyaluronic acid (GH), as well GH with addition gelatin crosslinked via transglutaminase (GH+Gel) temporally control...
Impaired contractility after myocardial infarction (MI) causes cardiogenic shock. MARK4 activity impairs post-MI by increasing α-tubulin detyrosination. We assessed the impact of naringenin, a small-molecule inhibitor, on post-MI. Naringenin (Nar) was encapsulated in PEG-PCL to augment bioavailability. Wistar rats were randomized receive either MI + micellized naringenin (0.3 mg/kg) [MI-NarMic], 1% DMSO [MI-NarDMSO], empty micelle [MI-Mic], alone [MI-Untreated], or no [Sham]. induced via...
Heart failure with preserved ejection (HFpEF) is a complex syndrome few therapies available to patients. Diastolic dysfunction common clinical feature among HFpEF patients, and strategies mitigate impaired relaxation may have therapeutic benefit. Recognizing that increased stabilization of the microtubule network induced by detyrosination α-tubulin contributes cardiomyocyte stiffness ex vivo , we explored if inhibition small molecule vasohibin inhibitor (VASHi) could improve in diastolic...
Impaired contractility and associated shock are significant contributors to morbidity after myocardial infarction (MI). Elevated MARK4 activity MI impairs by increasing α-tubulin detyrosination. As such, we developed a nanoparticle-based therapeutic strategy enhance myocyte function with small molecule inhibitor (naringenin) tested its ability improve in rat model of MI. Naringenin was encapsulated PEO-PCL augment bioavailability. Adult Wistar rats underwent thoracotomy were randomized...
Introduction: Stress cardiomyopathy is characterized by transient contractile dysfunction with a poorly understood mechanism. Targeting metabolic derangements has proven efficacious in chronic heart failure, but the role of metabolism acute cardiac ill-defined. Hypothesis: Characterizing any alterations stress may help identify potential therapeutic targets. Methods: Sprague-Dawley rats (350 ± 57 g) were given single intraperitoneal injection 75 mg/kg isoprenaline. Animals allocated into...