A5065802180- Transplantation: Methods and Outcomes
- Mechanical Circulatory Support Devices
- Cardiac Structural Anomalies and Repair
- Renal Transplantation Outcomes and Treatments
- Organ Transplantation Techniques and Outcomes
- Cardiac Valve Diseases and Treatments
- Aortic Disease and Treatment Approaches
- Cardiac Arrest and Resuscitation
- Cardiac, Anesthesia and Surgical Outcomes
- Aortic aneurysm repair treatments
- Congenital Heart Disease Studies
- Viral Infections and Immunology Research
- Cardiac Ischemia and Reperfusion
- Infective Endocarditis Diagnosis and Management
- Cardiac and Coronary Surgery Techniques
- Organ and Tissue Transplantation Research
- Heart Failure Treatment and Management
- Pneumocystis jirovecii pneumonia detection and treatment
- Cardiac pacing and defibrillation studies
- Fuel Cells and Related Materials
- Cardiomyopathy and Myosin Studies
- Electrospun Nanofibers in Biomedical Applications
- Pulmonary Hypertension Research and Treatments
- Tissue Engineering and Regenerative Medicine
- Connective tissue disorders research
Hospital of the University of Pennsylvania
2018-2025
University of Pennsylvania
2019-2025
Philadelphia University
2022-2023
Master's College
2023
California University of Pennsylvania
2021
Message Pharmaceuticals (United States)
2020
University of California, Los Angeles
2015-2019
Core Laboratories (United States)
2019
UCLA Medical Center
2019
Olive View-UCLA Medical Center
2016-2018
The 2018 United Network for Organ Sharing allocation policy change has led to a significant increase in the use of mechanical circulatory support devices patients listed orthotopic heart transplantation. However, there been paucity data regarding newest generation Impella 5.5, which received FDA approval 2019.The registry was queried all adults awaiting transplantation who 5.5 during their listing period. Waitlist, device, and early post-transplant outcomes were assessed.A total 464 period...
Despite the development of novel procurement technologies, an imbalance remains between demand for and availability donor hearts. We aimed to identify characteristics predictive nonutilization hearts supported by ex vivo perfusion. A national database was used perfused before September 30, 2023. Donors were stratified into cohorts “Used” “Discarded” based on final allocation. Logistic regressions developed predictors in both non- Of 1,393 with perfusion, 154 (11%) unused. Unused donors older...
Extracorporeal membrane oxygenation (ECMO) utilization for primary pulmonary hypertension (PPHTN) remains controversial. This multicenter, retrospective analysis of the Life Support Organization Registry evaluated 221 PPHTN patients placed on ECMO in 2000–2019. Survival by indications and cannulation strategies were compared with Kaplan–Meier analyses. mortality risk factors analyzed using Cox proportional hazards regressions. The overall rate survival to decannulation was 140/221 (63.3%),...
In this study, we compare the clinical characteristics and courses of patients directly bridged to heart transplant with intraaortic balloon pump (IABP) versus Impella 5.5. We performed a retrospective cohort study single-center institutional data including all adult at our institution either IABP or 5.5 support between October 18, 2018, May 31, 2023. Ninety-one recipients were included in whom 54 (59%) on 37 (41%) Patients supported had comparable baseline compared those (all p > 0.05)....
Although total body perfusion with extracorporeal life support (ECLS) can be maintained for weeks, individual organ beyond 12 hours has yet to achieved clinically. Normothermic ex situ heart (ESHP) offers the potential prolonged cardiac preservation. We developed an ESHP system study effect of perfusate variables on preservation, ultimate goal extending ≥24 hours. Forty porcine hearts were perfused a target Hearts that electromechanical activity and had <3× increase in vascular resistance...
Heart failure with preserved ejection fraction (HFpEF) is a complex syndrome associated increased myocardial stiffness and cardiac filling abnormalities. Prior studies implicated α-tubulin detyrosination, which catalyzed by the vasohibin enzymes, as contributor to stabilization of cardiomyocyte microtubule network (MTN) in failing human hearts. We explored whether MTN detyrosination contributed impaired diastolic function ZSF1 obese rat model HFpEF designed small-molecule inhibitor ablate...
The compliant thoracic artificial lung (cTAL) has been studied in acute vivo and vitro experiments. cTAL's long-term function potential use as a bridge to transplantation are assessed presently. cTAL without anticoagulant coatings was attached sheep (n = 5) via the pulmonary artery left atrium for 14 days. Systemic heparin anticoagulation used. Compliant resistance, gas exchange, hematologic parameters, organ were recorded. Two euthanized nondevice-related issues. resistance averaged 1.04 ±...
We report midterm results of Impella 5.5 use with focus placed on bridge-outcomes, venoarterial extracorporeal membrane oxygenation (VA-ECMO) transition, complications, and risk factors for mortality. A retrospective review patients implanted the at our medical center was conducted. Forty were included varying bridge strategies. Sixteen (40%) supported <14 days, 13 (32.5%) 14–30 11 (27.5%) >30 days. Thirty day mortality 22.5% (9/40). Twenty-five (62.5%) successfully bridged to...
There is limited data to inform minimum case requirements for training in robotically assisted coronary artery bypass grafting (RA-CABG). Current recommendations rely on nonclinical endpoints and expert opinion.To determine the number of RA-CABG procedures required achieve stable clinical outcomes.We included isolated Society Thoracic Surgeons (STS) registry performed between 2014 2019 by surgeons without prior experience. Outcomes were approach conversion, reoperation, major morbidity or...
Background Little is known regarding the impact of donor COVID-19 status on recipient outcomes after heart transplantation. In this study, we characterize first 110 transplants from organ donors positive for (COVID-19+) in United States. Methods and Results Retrospective analysis Network Organ Sharing database was performed single-organ adult January 2020 to March 2022. Donor COVID-19+ defined as a nucleic acid amplification, antigen, or other test within 7 days transplant. Nearest-neighbor...
Abstract Heart transplantation in children with intellectual disability (ID) is an issue of debate due to the shortage available donor organs. We sought perform first large‐scale retrospective cohort study describing prevalence and outcomes heart this population. The United Network Organ Sharing database was queried from 2008 2015 for pediatric patients (age <19 years) receiving first, isolated transplant. Recipients were divided into three subgroups: definite ID, probable no ID....