A5072523780- Congenital heart defects research
- Congenital Heart Disease Studies
- Diversity and Career in Medicine
- Health and Medical Research Impacts
- Lung Cancer Treatments and Mutations
- Cardiac Valve Diseases and Treatments
- Cardiac Structural Anomalies and Repair
- Lung Cancer Diagnosis and Treatment
- Bariatric Surgery and Outcomes
- Mechanical Circulatory Support Devices
- Cardiac, Anesthesia and Surgical Outcomes
- Body Contouring and Surgery
- COVID-19 and healthcare impacts
- Tissue Engineering and Regenerative Medicine
- Healthcare professionals’ stress and burnout
- Obesity and Health Practices
- Cardiac Imaging and Diagnostics
- Lung Cancer Research Studies
- SARS-CoV-2 and COVID-19 Research
- Viral Infections and Outbreaks Research
- Prenatal Substance Exposure Effects
- Proteoglycans and glycosaminoglycans research
- Acute Myocardial Infarction Research
- Transplantation: Methods and Outcomes
- Global Cancer Incidence and Screening
Hospital of the University of Pennsylvania
2023-2025
Pennsylvania Hospital
2024
University of Pennsylvania
2023-2024
University of Southern California
2015-2023
Keck Hospital of USC
2019-2022
Children's Hospital of Los Angeles
2015-2022
ORCID
2022
American Physician Scientists Association
2020
Osaka University
2020
Yale University
2020
In this study, we compare the clinical characteristics and courses of patients directly bridged to heart transplant with intraaortic balloon pump (IABP) versus Impella 5.5. We performed a retrospective cohort study single-center institutional data including all adult at our institution either IABP or 5.5 support between October 18, 2018, May 31, 2023. Ninety-one recipients were included in whom 54 (59%) on 37 (41%) Patients supported had comparable baseline compared those (all p > 0.05)....
Physician-scientists have long been considered an endangered species, and their extended training pathway is vulnerable to disruptions. This study investigated the effects of COVID-19-related challenges on personal lives, career activities, stress levels, research productivity physician-scientist trainees faculty.The authors surveyed medical students (MS), graduate (GS), residents/fellows (R/F), faculty (F) using a tool distributed 120 U.S. institutions with MD-PhD programs in April-June...
Mechanical circulatory support (MCS) as a bridge to lung transplant is an infrequent but accepted pathway in patients who have refractory end-stage pulmonary failure. The American Association of Thoracic Surgeons Expert Consensus Guidelines, published 2023, recommends venovenous (VV) extracorporeal membrane oxygenation (ECMO) the initial configuration for those failed conventional medical therapy, including mechanical ventilation, while waiting transplantation and needing MCS. Alternatively,...
Abstract Purpose Physician-scientists play a crucial role in advancing biomedical sciences. Proportionally fewer physicians are actively engaged scientific pursuits, attributed to attrition the training and retention pipeline. This national study evaluated ongoing longer-term impact of COVID-19 pandemic on stress levels, research productivity, optimism for physician-scientists at all levels training. Methods A multi-institutional cross-sectional survey medical students, graduate...
Abstract Background Recently, there have been concerted efforts to improve racial and ethnic diversity in the physician-scientist workforce. Identifying factors associated with career choices among those underrepresented medicine science is a necessary first step advance this objective. The aim of present study was assess attitudes academic research interests predoctoral physician-scientists. Methods A cross-sectional 70-question survey distributed all single degree (MD or DO) dual (MD/PhD...
Abstract Background Though the proportion of women in medical schools has increased, gender disparities among those who pursue research careers still exists. In this study, we seek to better understand main factors contributing existing students choosing research. Methods A secondary cross-sectional cohort analysis previously published data was conducted using a 70-item survey that sent 16,418 at 32 academic centers, and IRB exempt from need for ethical approval University Illinois Chicago...
Lung branching morphogenesis relies on a number of factors, including proper epithelial cell proliferation and differentiation, polarity, migration. Rac1, small Rho GTPase, orchestrates these cellular processes, alignment, polarization. Furthermore, Rac1 modulates both noncanonical canonical Wnt signaling, important pathways in lung morphogenesis. Culture embryonic mouse explants the presence inhibitor (NSC23766) resulted dose-dependent decrease branching. Increased death BrdU uptake were...
The role played by Notch pathway in cardiac progenitor cell biology remains to be elucidated. Delta-like ligand-4 (Dll4), the arterial-specific ligand, is expressed second heart field (SHF) progenitors at time-points crucial SHF biology. Dll4-mediated signaling critically required for maintaining an adequate pool of progenitors, such that Dll4 knockout results reduction proliferation and increase apoptosis. Reduced leads underdeveloped right ventricle (RV) outflow tract (OFT). In its most...
Injury to healthy dermis and the dermoepidermal junction initiates a robust healing process consisting of fibrous tissue overgrowth, collagen deposition, scar formation. The conventional management scars other skin injuries has largely relied upon surgical soft transfer resurface and/or replace damaged dysmorphic with new skin. However, these strategies are invasive, expensive, may further exacerbate integumentary injury. In this study, we examine creation in situ redox generated pH changes...
Abstract Our previous work demonstrating enrichment of outflow tract (OFT) congenital heart disease (CHD) in children with cleft lip and/or palate (CL/P) suggests derangements common underlying developmental pathways. The current pilot study examines the genetics concomitant nonsyndromic CL/P and OFT CHD phenotype. Of 575 patients who underwent surgery at Children's Hospital Los Angeles, seven CHD, negative chromosomal microarray analysis, no recognizable syndromic association were recruited...