A5029252272- Amyloidosis: Diagnosis, Treatment, Outcomes
- Pituitary Gland Disorders and Treatments
- Mosquito-borne diseases and control
- Virology and Viral Diseases
- SARS-CoV-2 and COVID-19 Research
- Immunotherapy and Immune Responses
- Head and Neck Surgical Oncology
- Monoclonal and Polyclonal Antibodies Research
- Viral Infections and Vectors
- CAR-T cell therapy research
- Diversity and Career in Medicine
- Galectins and Cancer Biology
- Alzheimer's disease research and treatments
- Meningioma and schwannoma management
- Health and Medical Research Impacts
- Cancer Immunotherapy and Biomarkers
- Cerebrospinal fluid and hydrocephalus
- Chronic Lymphocytic Leukemia Research
- Synthesis of Tetrazole Derivatives
- Glycosylation and Glycoproteins Research
- COVID-19 Clinical Research Studies
- Protein Structure and Dynamics
- Chemical Synthesis and Analysis
- SARS-CoV-2 detection and testing
- Malaria Research and Control
University of California, Los Angeles
2015-2025
California Institute of Technology
2016-2024
UCLA Health
2022
Howard Hughes Medical Institute
2014-2018
University of Cambridge
2016
Genomics (United Kingdom)
2015
The coronavirus disease 2019 (COVID-19) pandemic presents an urgent health crisis. Human neutralizing antibodies that target the host ACE2 receptor-binding domain (RBD) of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) spike protein
Overproduction of immunoglobulin light chains leads to systemic amyloidosis, a lethal disease characterized by the formation amyloid fibrils in patients' tissues. Excess are equilibrium between dimers and less stable monomers which can undergo irreversible aggregation state. The therefore must disassociate into prior forming fibrils. Here we identify ligands that inhibit stabilizing Mcg chain variable domain dimer shifting away from amyloid-prone monomer.
Abstract The COVID-19 pandemic presents an urgent health crisis. Human neutralizing antibodies (hNAbs) that target the host ACE2 receptor-binding domain (RBD) of SARS-CoV-2 spike 1–5 show therapeutic promise and are being evaluated clincally 6–8 . To determine structural correlates neutralization, we solved 8 new structures distinct hNAbs 5 in complex with trimer or RBD. Structural comparisons allowed classification into categories: (1) VH3-53 short CDRH3s block bind only to “up” RBDs, (2)...
<h3>BACKGROUND AND PURPOSE:</h3> Glioblastoma is a common primary brain tumor with poor but variable prognosis. Our aim was to investigate the feasibility of MR perfusion imaging by using arterial spin-labeling for determining prognosis patients glioblastoma. <h3>MATERIALS METHODS:</h3> Pseudocontinuous 3D background-suppressed gradient and spin-echo acquired before surgery on 53 subsequently diagnosed The calculated CBF color maps were visually evaluated 3 independent readers blinded...
Human infection by Zika virus (ZIKV) during pregnancy can lead to vertical transmission and fetal aberrations, including microcephaly. Prophylactic administration of antibodies diminish or prevent ZIKV in animal models, but whether passive immunization protect nonhuman primates their fetuses has not been determined. Z004 Z021 are neutralizing monoclonal domain III the envelope (EDIII) ZIKV. Together two nonpregnant macaques against even after Fc modifications antibody-dependent enhancement...
Abstract Background Though the proportion of women in medical schools has increased, gender disparities among those who pursue research careers still exists. In this study, we seek to better understand main factors contributing existing students choosing research. Methods A secondary cross-sectional cohort analysis previously published data was conducted using a 70-item survey that sent 16,418 at 32 academic centers, and IRB exempt from need for ethical approval University Illinois Chicago...
When double-strand breaks (DSBs) in DNA remain unrepaired, catastrophic loss of genes occurs, leading to translocations, mutations and carcinogenesis. If a sister chromatid is not available at the DSB, non-homologous end joining (NHEJ) used join broken ends. The NHEJ pathway comprises synapsis, processing ligation. Here, we ask how DSBs are repaired efficiently. We suggest that colocation proteins achieved over time by following components: stages, where main actors assembled, scaffolds...
Recent epidemics demonstrate the global threat of Zika virus (ZIKV), a flavivirus transmitted by mosquitoes. Although infection is usually asymptomatic or mild, newborns infected mothers can display severe symptoms, including neurodevelopmental abnormalities and microcephaly. Given large-scale spread, symptom severity, lack treatment prophylaxis, safe effective ZIKV vaccine urgently needed. However, design complicated concern that elicited antibodies (Abs) may cross-react with other...
Patients with giant adenomas are more likely to have tumor extension into the paranasal sinuses. Compared macroadenomas, not associated worse preoperative SNOT-22 scores.
Abstract At the heart of most cancer immunotherapies are specific interactions between principal cell killers, T cells, and antigens presented by tumor cells. Those may be exposed through use checkpoint inhibitors, or they can amplified engineered cell-based therapies. A class that has emerged as being particularly important neoantigens, which small fragments mutated proteins contain mutation, and, for CD8+ recognition, MHC Class I. In principle, neoantigens draw cells into a comprise...
Introduction: Pituitary macroadenomas are tumors >1 cm and <4 cm, while giant adenomas ≥4 cm. Both have the propensity to extend into surrounding structures, such as suprasellar infrasellar regions. It is unknown if 22-Item SinoNasal Outcome Test (SNOT-22) scores affected by adenoma size. The main objectives of this study were compare preoperative SNOT-22 scores, tumor characteristics, imaging findings among patients who underwent transnasal transsphenoidal (TNTS) resection pituitary or adenomas.
Introduction: Pituitary macroadenomas commonly extend into the suprasellar space, cavernous sinus, and sphenoid sinus. The sinus is an important corridor essential entry point for endoscopic transnasal transsphenoidal surgery (ETTS) pituitary tumors. We aim to investigate anatomic pathologic features that may play a role in extrasellar tumor extension
Objective: To describe the characteristics and outcomes of patients undergoing endoscopic endonasal revision surgery for recurrent pituitary adenomas.