A5050294466- Wnt/β-catenin signaling in development and cancer
- Nematode management and characterization studies
- Cancer Mechanisms and Therapy
- Cancer-related gene regulation
- Pituitary Gland Disorders and Treatments
- Epigenetics and DNA Methylation
- Cancer Cells and Metastasis
- DNA Repair Mechanisms
- Legume Nitrogen Fixing Symbiosis
- Ion channel regulation and function
- Hippo pathway signaling and YAP/TAZ
- Banana Cultivation and Research
- Reproductive Biology and Fertility
- Glioma Diagnosis and Treatment
- Cancer-related Molecular Pathways
- Plant Pathogens and Fungal Diseases
- Chemical Reactions and Isotopes
- Ion Transport and Channel Regulation
- Prenatal Screening and Diagnostics
- 14-3-3 protein interactions
- Meningioma and schwannoma management
- Histone Deacetylase Inhibitors Research
- Nicotinic Acetylcholine Receptors Study
- Head and Neck Surgical Oncology
- Cellular transport and secretion
University of California, Los Angeles
2023-2025
Johns Hopkins Medicine
2018-2022
Johns Hopkins University
2018-2022
Jacksonville College
2022
Mayo Clinic in Florida
2022
Norwegian Womens Public Health Association
2020
University of Hawaiʻi at Mānoa
1997-2016
While an association between Parkinson's disease (PD) and viral infections has been recognized, the impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on PD progression remains unclear. Here, we demonstrate that SARS-CoV-2 infection heightens risk using human embryonic stem cell (hESC)-derived dopaminergic (DA) neurons a angiotensin-converting enzyme (hACE2) transgenic (Tg) mouse model. Our findings reveal exacerbates susceptibility cellular toxicity in DA pre-treated...
Abstract Progression of benign tumors to invasive, metastatic cancer is accompanied by the epithelial-to-mesenchymal transition (EMT), characterized loss cell-adhesion protein E-cadherin. Although silencing mutations and transcriptional repression E-cadherin gene have been widely studied, not much known about posttranslational regulation in tumors. We show that tightly coexpressed with secretory pathway Ca2+-ATPase isoform 2, SPCA2 (ATP2C2), breast Loss impairs surface expression elicits...
A complex interplay between the extracellular space, cytoplasm and individual organelles modulates Ca2+ signaling to impact all aspects of cell fate function. In recent years, molecular machinery linking endoplasmic reticulum stores plasma membrane entry has been defined. However, mechanism pathophysiological relevance store-independent modes remain poorly understood. Here, we describe how secretory pathway Ca2+-ATPase SPCA2 promotes cycle progression survival by activating through Orai1...
Six proteins, ORC1–6, make up the origin recognition complex (ORC) that initiates licensing of DNA replication origins. We have previously reported subunit ORC2 is localized between separating maternal chromosomes at anaphase II just after fertilization and present in zygotic pronuclei G1. Here, we found ORC1, 3, 5 all localize II, but could not be detected ORC6 to periphery nucleoli stages. identified an unexpected potential role for ORC4 polar body formation. both female meiotic divisions,...
Downy mildew of impatiens (Impatiens walleriana Hook.f.) was first reported from the continental United States in 2004. In 2011 to 2012, severe and widespread outbreaks were documented across mainland, resulting considerable economic losses. On May 5, 2013, downy disease symptoms observed I. 'Super Elfin' at a retail nursery Mililani, on Hawai'ian island Oahu. Throughout June additional sightings islands Oahu, Kauai, Maui, Hawai'i nurseries, home gardens, botanical park landscape plantings....
The secretory pathway Ca2+-ATPase SPCA2 is a tumor suppressor in triple receptor negative breast cancer (TNBC), highly aggressive molecular subtype that lacks tailored treatment options. Low expression of TNBC confers poor survival prognosis patients. Previous work has established re-introducing to cells restores basal Ca2+ signaling, represses mesenchymal gene expression, mitigates migration vitro and metastasis vivo. In this study, we examined the effect histone deacetylase inhibitors...
A small population of self-renewing stem cells initiate tumors and maintain therapeutic resistance in glioblastoma (GBM). Given the limited treatment options dismal prognosis for this disease, there is urgent need to identify drivers that could be druggable targets. Previous work showed endosomal pH regulator NHE9 upregulated GBM correlates with worse survival prognosis. Here, we probed aberrant signaling pathways patient-derived found increases cell surface expression phosphorylation...
Abstract Progression of benign tumors to invasive, metastatic cancer is accompanied by the epithelial mesenchymal transition (EMT), characterized loss cell-adhesion protein E-cadherin. Although silencing mutations and transcriptional repression E-cadherin gene have been widely studied, not much known about post-translational regulation in tumors. We show that tightly co-expressed with secretory pathway Ca 2+ -ATPase isoform 2, SPCA2 ( ATP2C2 ), breast Loss impairs surface expression elicits...
Objectives Cervical chordoma is a rare, low‐grade primary bone tumor occurring in the axial skeleton. Due to challenges surgical exposure caused by anatomic location, patients may experience dysfunction speech and swallowing. The objective of this study was characterize swallowing outcomes for undergoing resection cervical chordoma. Moreover, we detail in‐depth two cases with similar initial presentations compare prognostic factors management strategies. Methods Eleven histologically...
SUMMARY Although the mainstay of treatment for hormone responsive breast tumors is targeted endocrine therapy, many patients develop de novo or acquired resistance and are treated with chemotherapeutic drugs. The vast majority (80%) estrogen receptor positive also express wild type p53 protein that a major determinant DNA damage response. Tumors ER+ WT respond poorly to chemotherapy, although underlying mechanisms not completely understood. We describe novel link between store independent Ca...
Patients with giant adenomas are more likely to have tumor extension into the paranasal sinuses. Compared macroadenomas, not associated worse preoperative SNOT-22 scores.
Abstract Introduction: Over 90% of cancer deaths in breast are associated with metastasis. Epithelial-mesenchymal transition (EMT) is the hallmark Dysregulation Ca2+ toolkit has profound consequences for tumor growth and metastasis, raising hopes novel avenues therapeutic intervention. The Secretory Pathway Ca2+-ATPase Isoform 2 (SPCA2) transports from cytoplasm to Golgi, elicits influx by interacting plasma membrane channels. Previously, we showed that SPCA2 implicated progression (Feng et...
The influence of container bases on nematode spread from infested pots or ground in an ornamental foliage nursery was investigated with Meloidogyne incognita as the test and cowpea indicator plant. examined were black cloth, concrete masonry blocks, gravel, crushed cinders, bare ground. Masonry blocks raised 46 cm above (raised bench) served control treatment. Under standard practice irrigation by rainfall supplemental overhead sprinkler, nematodes contaminated to adjacent nematode-free all...
The secretory pathway Ca2+-ATPase SPCA2 is a tumor suppressor in triple receptor negative breast cancer (TNBC), highly aggressive molecular subtype that lacks tailored treatment options. Low expression of TNBC confers poor survival prognosis patients. Previous work has established re-introducing to cells restores basal Ca2+ signaling, represses mesenchymal gene expression, mitigates migration vitro and metastasis vivo. In this study, we examined the effect histone deacetylase inhibitors...
ABSTRACT A small population of self-renewing stem cells initiate tumors and maintain therapeutic resistance in glioblastoma. Given the limited treatment options dismal prognosis for this disease there is urgent need to identify drivers that could be druggable targets. Previous work showed endosomal pH regulator NHE9 upregulated glioblastoma correlates with worse survival prognosis. Here, we probed aberrant signaling pathways patient-derived found increases cell surface expression...