A5101807621- Cancer Immunotherapy and Biomarkers
- Neuroblastoma Research and Treatments
- Radiopharmaceutical Chemistry and Applications
- Immunotherapy and Immune Responses
- Immune cells in cancer
- CAR-T cell therapy research
- Cancer, Stress, Anesthesia, and Immune Response
- Immune Cell Function and Interaction
- Glioma Diagnosis and Treatment
- Cancer Cells and Metastasis
- Ferroptosis and cancer prognosis
- Neuropeptides and Animal Physiology
- Ubiquitin and proteasome pathways
- Pancreatic and Hepatic Oncology Research
- Nanoparticle-Based Drug Delivery
- Stress Responses and Cortisol
- Apelin-related biomedical research
- Extracellular vesicles in disease
- Prostate Cancer Treatment and Research
- Tendon Structure and Treatment
- Bladder and Urothelial Cancer Treatments
- Ultrasound Imaging and Elastography
- Thermoelastic and Magnetoelastic Phenomena
- Whipple's Disease and Interleukins
- Inflammatory Biomarkers in Disease Prognosis
Massachusetts General Hospital
2024-2025
Harvard University
2024-2025
University of Rochester
2023-2025
University of Rochester Medical Center
2019-2024
Stonehill College
2020
Czech Academy of Sciences, Institute of Microbiology
2019
Over 80% of pancreatic ductal adenocarcinoma (PDA) patients are diagnosed with non-resectable late-stage disease that lacks effective neoadjuvant therapies. Stereotactic body radiation therapy (SBRT) has shown promise as an emerging approach for treating PDA, and here, we report its combination local interleukin-12 (IL-12) microsphere (MS) immunotherapy results in marked tumor reduction cures multiple preclinical mouse models PDA. Our findings demonstrate increase intratumoral interferon...
Stereotactic body radiotherapy (SBRT) has been increasingly used as adjuvant therapy in pancreatic ductal adenocarcinoma (PDAC), and induces immunogenic cell death, which leads to the release of tumor antigen damage-associated molecular patterns. However, this induction often fails generate sufficient response overcome pre-existing microenvironment (TME) immunosuppression. Toll-like receptor (TLR) 7/8 ligands, such R848, can amplify effect vaccines, with recent evidence showing its antitumor...
Radiation is used to treat pancreatic ductal adenocarcinoma (PDAC) in the locally-advanced setting. Stereotactic body radiation therapy (SBRT), particular, has shown improved outcomes against conventional RT a number of clinical trials. One key cell type involved response are neutrophils. These innate immune cells first responders tissue damage and infiltrate irradiated tumors high numbers rectify injury. Neutrophils typically possess an immunosuppressive, wound healing phenotype this...
Ependymoma (EPN) is a common form of brain tumor in children, often resistant to available cytotoxic therapies. Molecular profiling studies have led better understanding EPN subtypes and revealed critical role oncogenes ZFTA–RELA fusion EPHB2 supratentorial ependymoma (ST-EPN). However, the immune system’s progression response therapy remains poorly understood. New treatments for various molecular are desperately needed. Using ST-EPN-ZFTA subtype-specific syngeneic mouse models, we found an...
Abstract Group 3 Medulloblastoma (G3MB) is a pediatric brain cancer with poor prognosis, and median 5-year overall survival of 45-58% in infants young children, respectively. Moreover, the current standard-of-care therapy – which includes spinal radiation causes tremendous morbidity. While immunotherapy immune checkpoint blockade has transformed treatment many malignancies, it yet to show benefit most common form tumors. Here we that B cell depletion using Rituximab; anti-CD20: -- an...
While ionizing radiation is a major form of cancer therapy, radioresistance remains therapeutic obstacle. We have previously shown that the mandated housing temperature for laboratory mice (∼22°C) induces mild, but chronic, cold stress resulting in increased circulating norepinephrine, which binds to, and triggers activation of, beta-adrenergic receptors (β-AR) on tumor immune cells. This adrenergic signaling increases cell intrinsic resistance to chemotherapy suppression anti-tumor...
Abstract Radiotherapy (RT) is commonly employed to treat solid tumors. Immune checkpoint blockade of programmed cell death protein 1 (PD-1) and CTLA-4 improves survival in RT patients, yet many fail respond combination therapy. Natural killer group 2 (NKG2) family receptors, particularly inhibitory NKG2A activating NKG2D, have emerged as promising therapeutic targets improve antitumor T responses; thus, we examined how these receptors their ligands (Qa-1b retinoic acid early inducible...
Tumor-derived extracellular vesicles (TEVs) play crucial roles in mediating immune responses, as they carry and present functional MHC-peptide complexes that enable them to modulate antigen-specific CD8+ T-cell responses. However, the therapeutic potential immunogenicity of TEV-based therapies against bladder cancer (BC) have not yet been tested. Here, we demonstrated priming with immunogenic Extracellular Vesicles (EVs) derived from murine MB49 BC cells was sufficient prevent tumor growth...
Abstract Rectal cancer ranks as the second leading cause of cancer-related deaths. Neoadjuvant therapy for rectal patients often results in individuals that respond well to and those poorly, requiring life-altering excision surgery. It is inadequately understood what dictates this responder/nonresponder divide. Our major aim identify factors tumor microenvironment drive a fraction radiotherapy. We also sought distinguish potential biomarkers would indicate positive response design...
The tumor-draining lymph node (TDLN) plays a role in tumor immunity. Intratumorally administered microspheres (MS) that encapsulate immunomodulatory agents have emerged as treatment strategy capable of causing profound changes the microenvironment (TME) and eliciting potent antitumor effects. We hypothesized local delivery MS to TME may also drain therefore target TDLN initiate immune responses.Fluorescent were injected into orthotopically implanted murine pancreatic tumors, tissues examined...
<h2>Abstract</h2><h3>Purpose</h3> Orthotopic tumors more closely recapitulate human cancers than do ectopic models; however, precision targeting of such internal for radiation therapy (RT) without inducing systemic toxicity remains a barrier. We developed an innovative murine orthotopic rectal tumor model where the insertion clinical grade titanium fiducial clips on opposing sides allowed targeted administration short-course (SCRT). With this novel approach, clinically relevant RT regimens...
Abstract Rectal cancer is a deadly disease typically treated using neoadjuvant chemoradiotherapy followed by total mesorectal excision surgery. To reduce the occurrence of surgery for patients whose tumors regress from therapy alone, conventional imaging, such as computed tomography (CT) or magnetic resonance imaging (MRI), used to assess tumor response before In this work, we hypothesize that shear wave elastography offers valuable insights into short-course radiation (SCRT)—information...
Abstract Purpose: Ependymoma (EPN) is a common type of brain tumor in children and often resistant to available cytotoxic therapies. Molecular profiling studies have led better understanding unique EPN subtypes revealed critical role EPHB2. However, the immune system's progression treatment response remains poorly understood. New treatments for are desperately needed should be developed molecular subtype-specific fashion. Experimental Design: We syngeneic mouse model using EPHB2-driven...
Abstract BACKGROUND Ependymoma (EPN) is a childhood brain cancer that often resistant to cytotoxic therapies. Molecular profiling has led better understanding of unique EPN subtypes and revealed critical role EPHB2 in driving disease. With this mind, new treatments for are desperately needed should be developed molecular subtype-specific fashion. METHODS We syngeneic mouse model EPHB2-driven genetically engineered tumor cells. performed transcriptomic analysis murine tumors human datasets...
<h3>Background</h3> Colorectal Cancer (CRC) is a devastating malignancy that ranks as the second leading cause of cancer-related deaths. Rectal cancer (RC) comprises one-third CRC cases, with over 50,000 people in US diagnosed each year. Short course radiation therapy (SCRT) being investigated curative treatment option for RC, aim to preserve organ function and avoid life-altering excision surgery. SCRT can significantly reduce tumor burden subset patients, however most patients' tumors do...
Supplementary Data from Modulation of the Human Pancreatic Ductal Adenocarcinoma Immune Microenvironment by Stereotactic Body Radiotherapy
Supplementary Data from Modulation of the Human Pancreatic Ductal Adenocarcinoma Immune Microenvironment by Stereotactic Body Radiotherapy
Supplementary Data from Modulation of the Human Pancreatic Ductal Adenocarcinoma Immune Microenvironment by Stereotactic Body Radiotherapy
Supplementary Data from Modulation of the Human Pancreatic Ductal Adenocarcinoma Immune Microenvironment by Stereotactic Body Radiotherapy
Supplementary Data from Modulation of the Human Pancreatic Ductal Adenocarcinoma Immune Microenvironment by Stereotactic Body Radiotherapy
Supplementary Data from Modulation of the Human Pancreatic Ductal Adenocarcinoma Immune Microenvironment by Stereotactic Body Radiotherapy
Supplementary Data from Modulation of the Human Pancreatic Ductal Adenocarcinoma Immune Microenvironment by Stereotactic Body Radiotherapy
Supplementary Data from Modulation of the Human Pancreatic Ductal Adenocarcinoma Immune Microenvironment by Stereotactic Body Radiotherapy