A5100370195- Tracheal and airway disorders
- Fungal Infections and Studies
- Antifungal resistance and susceptibility
- Lung Cancer Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Autoimmune Bullous Skin Diseases
- Autophagy in Disease and Therapy
- Nutrition and Health in Aging
- COVID-19 and healthcare impacts
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cancer Immunotherapy and Biomarkers
- Cancer, Hypoxia, and Metabolism
- Asthma and respiratory diseases
- Adipokines, Inflammation, and Metabolic Diseases
- Lung Cancer Research Studies
- Lung Cancer Treatments and Mutations
- Bacterial Identification and Susceptibility Testing
- COVID-19 Clinical Research Studies
- Clinical Nutrition and Gastroenterology
- Long-Term Effects of COVID-19
- Neuropeptides and Animal Physiology
- Respiratory Support and Mechanisms
- Head and Neck Surgical Oncology
- Biochemical effects in animals
- Kruppel-like factors research
Institute of Forensic Science
2025
Ministry of Public Security of the People's Republic of China
2025
Zhejiang Hospital
2024
Hunan Normal University
2024
Sun Yat-sen University
2024
National Center for Biotechnology Information
2007-2023
National Institutes of Health
2007-2023
Hangzhou First People's Hospital
2011-2022
Zhejiang University
2019-2022
University of Rochester Medical Center
2019-2022
AGGF1 is an angiogenic factor with therapeutic potential to treat coronary artery disease (CAD) and myocardial infarction (MI). However, the underlying mechanism for AGGF1-mediated angiogenesis unknown. Here, we show first time that activates autophagy, a housekeeping catabolic cellular process, in endothelial cells (ECs), HL1, H9C2, vascular smooth muscle cells. Studies Atg5 small interfering RNA (siRNA) autophagy inhibitors bafilomycin A1 (Baf) chloroquine demonstrate required EC...
Over 80% of pancreatic ductal adenocarcinoma (PDA) patients are diagnosed with non-resectable late-stage disease that lacks effective neoadjuvant therapies. Stereotactic body radiation therapy (SBRT) has shown promise as an emerging approach for treating PDA, and here, we report its combination local interleukin-12 (IL-12) microsphere (MS) immunotherapy results in marked tumor reduction cures multiple preclinical mouse models PDA. Our findings demonstrate increase intratumoral interferon...
Abstract The etiology of human autoimmune diseases in general remains largely unknown, although the genetic and environmental interplay may be relevant. This applies to skin such as pemphigus phenotypes others. In this group, there is an endemic form foliaceus (also known fogo selvagem [FS]) which pathogenic IgG4 autoantibody response self-antigen desmoglein 1 (Dsg1) cross-reacts with LJM11 sand fly salivary gland Ag. investigation, we dissected repertoires used by FS patients endogenous...
Background: Talaromyces marneffei, also named Penicillium is an opportunistic pathogen that can cause systemic or limited infection in human beings. This especially common immunodeficiency virus (HIV)-infected hosts; however, it has been recently reported HIV-negative hosts. Here, we report a very rarely seen case of T. marneffei pulmonary non-HIV-infected patient with signal transducer and activator transcription 3 ( STAT3) mutation. Case presentation: A 34-year-old woman was admitted to...
Astragaloside IV (AS-IV), a main active constituent of Astragalus membranaceus, has been confirmed to have antiasthmatic effects. However, it remained unclear whether the beneficial effects AS-IV on asthma were attributed mTOR inhibition; this issue was focus present work. BALB/c mice sensitized and challenged with ovalbumin followed 3 weeks rest/recovery then reexposure ovalbumin. administrated during time rest reexposure. The characteristic features allergic asthma, including airway...
Treadmill exercise promotes liver fat uptake, activates lipolysis and inhibits DNL, autolysosomes through APN-AdipoR1 to accelerate protect hepatocytes from lipotoxicity.
Abstract Pemphigus vulgaris (PV) encompasses two clinical phenotypes, one producing mucosal blisters and the other skin lesions (mcPV). The blister-producing PV variant is characterized by autoantibodies against desmoglein (Dsg)3, whereas lesion-producing to Dsg3 Dsg1. present study was aimed at disclosing diversity clonality of anti-Dsg3 response, as well whether B cells are Ag selected. Human-mouse heterohybridomas were generated fusion EBV-transformed or freshly isolated PBLs from six...
Abstract Analysis of an individual’s immunoglobulin (IG) gene repertoire requires the use high-quality germline Reference Sets. The Adaptive Immune Receptor Repertoire-Community (AIRR-C) Sets have been developed to include only human IG heavy and light chain alleles that confirmed by evidence from multiple sources. By including those with a high level support, some new sequences currently lack official names, AIRR-seq analysis will greater accuracy studies evolution genes, their allelic...
Based on the role of Ku80 in mediating radiation-induced DNA repair, we investigated expression human lung cancers different pathological types and evaluated effect radiotherapy levels a mouse model. We used immunohistochemistry real-time PCR to determine protein mRNA levels, respectively. inoculated nude mice with A549 cells subjected tumor-bearing varying doses irradiation. Lung carcinoma tissue exhibited higher when compared normal tissue. Among tumor subtypes, adenocarcinoma squamous...
G protein-coupled receptor, family C, group 5 member A (GPRC5A) is a retinoid-inducible protein, which has been characterized as tumor-suppressor gene in lung cancer. The present study further examined GPRC5A expression non-small cell cancer (NSCLC) for any association with the clinical features and treatment outcomes of patients NSCLC. total 30 paired NSCLC tumor adjacent normal tissues were analyzed detection mRNA protein using reverse transcription-quantitative polymerase chain reaction...
Medical implants with customizable design capabilities are an important direction for high-end medical devices. An standard in implant is to match the mechanical properties of implantation site. Inspired by 'cartilage ring-connective tissue' structure natural tracheal, we propose a approach tracheal stent composed 'skeleton + filling matrix'. By establishing mapping model structural parameters and J-type response properties, realize larger degree freedom adjusting properties. This uniquely...
The early diagnosis of chronic pulmonary aspergillosis (CPA) remains challenging. Currently, a new quantitative IgM antibody assay that enveloped purified galactomannan extracted from Aspergillus fumigatus as antigen was commercially available in China, but its diagnostic value to be established. To evaluate the role this commercial for CPA, multi-center prospective study performed 12 hospitals Zhejiang Province, January 1 December 31, 2016. Adult inpatients without severe immunocompromised...
Introduction Pancreatic ductal adenocarcinoma (PDAC) is notorious for its associated skeletal muscle wasting (SMW) and mortality. Currently, the relationships between PDAC, SMW, survival are poorly understood. Thus, there great need a faithful small animal model with quantitative longitudinal outcome measures that recapitulate clinical to define SMW onset assess progression. Therefore, we aimed validate dual energy X-ray absorptiometry (DEXA) as measure of lean mass, demonstrate utility...
Abstract Background Skeletal muscle wasting (SMW) in cancer patients is associated with increased morbidity, mortality, treatment intolerance and discontinuation, poor quality of life. This particularly true for pancreatic ductal adenocarcinoma (PDAC), as over 85% experience SMW, which responsible ~30% patient deaths. While the established paradigm to explain SMW posits that catabolism from systemic inflammation nutritional deficiencies, cause death, cellular molecular mechanisms remain be...