A5049151547- Lattice Boltzmann Simulation Studies
- Coronary Interventions and Diagnostics
- Rheology and Fluid Dynamics Studies
- Fluid Dynamics and Turbulent Flows
- Blood properties and coagulation
- Drug Solubulity and Delivery Systems
- Cardiovascular Health and Disease Prevention
- Electrohydrodynamics and Fluid Dynamics
- Nanoparticle-Based Drug Delivery
- Electrospun Nanofibers in Biomedical Applications
- Advanced Mathematical Modeling in Engineering
- Surfactants and Colloidal Systems
- Aerosol Filtration and Electrostatic Precipitation
- Advanced Sensor and Energy Harvesting Materials
- Elasticity and Material Modeling
- Advancements in Transdermal Drug Delivery
- Heat and Mass Transfer in Porous Media
- Nanofluid Flow and Heat Transfer
- Fluid Dynamics and Vibration Analysis
- Protein purification and stability
- Crystallization and Solubility Studies
- Advanced Drug Delivery Systems
- Navier-Stokes equation solutions
- Generative Adversarial Networks and Image Synthesis
- Advanced Numerical Methods in Computational Mathematics
Istituto per le Applicazioni del Calcolo Mauro Picone
2015-2024
Ospedale SS. Annunziata
2022
University of Salento
2017
Istituto Nanoscienze
2017
National Research Council
2009-2017
Sheffield Hallam University
2013
IAC (United States)
2009-2012
National Academies of Sciences, Engineering, and Medicine
2005
Atherosclerosis (AS), the underlying cause of most cardiovascular events, is one common causes human morbidity and mortality worldwide due to lack an efficient strategy for targeted therapy. In this work, we aimed develop ideal biomimetic nanoparticle AS Methods: Based on macrophage "homing" into atherosclerotic lesions cell membrane coating nanotechnology, nanoparticles (MM/RAPNPs) were fabricated with a (MM) surface rapamycin-loaded poly (lactic-co-glycolic acid) copolymer (PLGA) (RAPNPs)....
Cardiovascular disease is the leading cause of mortality worldwide. Atherosclerosis, one most common forms disease, characterized by a gradual formation atherosclerotic plaque, hardening, and narrowing arteries. Nanomaterials can serve as powerful delivery platforms for atherosclerosis treatment. However, their therapeutic efficacy substantially limited in vivo due to nonspecific clearance mononuclear phagocytic system. In order address this limitation, rapamycin (RAP)-loaded poly(lactic-
In this paper we present a general model of drug release from delivery device and the subsequent transport in biological tissue. The incorporates diffusion, dissolution solubility polymer coating, coupled with convection reaction Each layer contains bound free phases so that resulting is two-phase two-layer system partial differential equations. One novelties generality each layer. Within our includes diffusion as well three different models dissolution. We show may also be used cases where...
Advances in material design have led to the rapid development of novel materials with increasing complexity and functions bioengineering. In particular, functionally graded (FGMs) offer important advantages various fields application. this work, we consider a heterogeneous reaction-diffusion model for an FGM spherical drug release system that generalizes multi-layer configuration arbitrary spatially-variable coefficients. Our proposes possible form diffusivity reaction rate exhibiting fixed...
In this paper we consider drug binding in the arterial wall following delivery by a drug-eluting stent. Whilst it is now generally accepted that non-linear saturable reversible model required to properly describe process, precise form of varies between authors. Our particular interest manuscript assessing what extent modelling specific and non-specific as separate phases important. We study issue extending recently developed coupled release tissue distribution, comparing simulated profiles...
Effective treatment of glioma and other central nervous system (CNS) diseases is hindered by the presence blood-brain barrier (BBB). A novel nano-delivery vehicle composed PLGA-lysoGM1/DOX micelles was developed to cross BBB for CNS treatment. We have shown that doxorubicin (DOX) as a model drug encapsulated in PLGA-lysoGM1 can achieve up 3.8% loading efficiency 61.6% encapsulation orthogonal test design. Our vitro experiments demonstrated had slow sustainable release under physiological...
This paper studies a steady axisymmetric flow in constricted rigid tube. A shear-thinning fluid modelling the deformation-dependent viscosity of blood is proposed. The motion equation written vorticity-streamfunction formulation and solved numerically by finite difference scheme. pattern with distributions pressure shear stress at wall are computed. dependence on dimensionless parameters has been investigated differences from Newtonian case discussed.
In this study, we designed a novel drug-eluting coating for vascular implants consisting of core the anti-proliferative drug docetaxel (DTX) and shell platelet glycoprotein IIb/IIIa receptor monoclonal antibody SZ-21. The core/shell structure was sprayed onto surface 316L stainless steel stents using coaxial electrospray process with aim creating that exhibited differential release two drugs. prepared displayed uniform nano/micro particles. vitro experiments were performed, demonstrated...
Osteosarcoma (OS) is a rare form of primary bone cancer, impacting approximately 3.4 × 10
We study the impact of wall corrugations in microchannels on process capillary filling by means three broadly used methods: computational fluid dynamics (CFD), lattice Boltzmann equations (LBE), and molecular (MD). The numerical results these approaches are compared tested against Concus−Finn (CF) criterion, which predicts pinning contact line at rectangular ridges perpendicular to flow for angles θ > 45°. Whereas = 30, 40 (no flow), 60° (flow) all methods found produce data consistent with...
A mathematical model describing the advection-diffusion reaction of a substance between two porous homogeneous media different properties and dimensions is presented. strong analogy with one-dimensional transient heat conduction process across layered slabs evidenced similar methodology proposed. The incorporates not only drug diffusive effects, but also convection phenomena metabolic processes in wall. Transformation separation variables leads to Sturm-Liouville problem discontinuous...
Abstract The problem of the steady flow three classes non‐linear fluids differential type past a porous plate with uniform suction or injection is studied. which studied counterpart classical ‘asymptotic suction’ problem, within context non‐Newtonian fluid models. equations resulting from balance momentum and mass, coupled suitable boundary conditions, are solved numerically either by finite difference method collocation B‐spline function basis. manner in various material parameters affect...
Non-Newtonian models with shear-thinning viscosity are commonly used to solve a variety of complex flow problems. A new finite-volume discretization based upon an unstructured grid is integrate the differential form lattice Boltzmann equation shear-dependent viscosity, using cell-vertex technique. The unknown fields placed at nodes mesh and evolve on basis fluxes crossing surfaces corresponding control volumes. Numerical results show satisfactory accuracy also in case relatively geometries...
This paper presents a chemo-mechano-biological framework for arterial physiopathology. The model accounts the fine remodelling in multiscale hierarchical arrangement of tissue constituents and diffusion molecular species involved cell-cell signalling pathways. Effects terms alterations compliance are obtained. A simple instructive example is introduced. Although oversimplified with respect to realistic case studies, proposed application mimics biochemical activity matrix metalloproteinases,...