A5087366083- Coronary Interventions and Diagnostics
- Electrospun Nanofibers in Biomedical Applications
- Glioma Diagnosis and Treatment
- 3D Printing in Biomedical Research
- Tissue Engineering and Regenerative Medicine
- Brain Metastases and Treatment
- Cardiac Valve Diseases and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Satellite Communication Systems
- MRI in cancer diagnosis
- Rheology and Fluid Dynamics Studies
- Monoclonal and Polyclonal Antibodies Research
- Spacecraft Design and Technology
- Nanoplatforms for cancer theranostics
- Aortic aneurysm repair treatments
- Radiopharmaceutical Chemistry and Applications
- Barrier Structure and Function Studies
- Cardiac and Coronary Surgery Techniques
- Mitochondrial Function and Pathology
- Advanced MRI Techniques and Applications
- Bacterial biofilms and quorum sensing
- Peripheral Artery Disease Management
- Metabolism and Genetic Disorders
- Cancer Treatment and Pharmacology
- Protein Interaction Studies and Fluorescence Analysis
Oregon Health & Science University
1984-2024
University of Strathclyde
2015-2024
Dalhousie University
2024
Rowan University
2023
Royal Belfast Hospital for Sick Children
2014
University Corporation for Atmospheric Research
2008
United States Naval Research Laboratory
2008
NSF National Center for Atmospheric Research
2008
NOAA Center for Satellite Applications and Research
2008
European Centre for Medium-Range Weather Forecasts
2008
The radio occultation (RO) technique, which makes use of signals transmitted by the global positioning system (GPS) satellites, has emerged as a powerful and relatively inexpensive approach for sounding atmosphere with high precision, accuracy, vertical resolution in all weather over both land ocean. On 15 April 2006, joint Taiwan-U.S. Constellation Observing System Meteorology, Ionosphere, Climate (COSMIC)/Formosa Satellite Mission 3 (COSMIC/FORMOSAT-3, hereafter COSMIC) mission,...
Delivery of viral particles to the brain is limited by volume distribution that can be obtained. Additionally, there currently no way non-invasively monitor virus following delivery central nervous system (CNS). To examine virus-sized across blood-brain barrier (BBB), dextran coated, superparamagnetic monocrystalline iron oxide particles, with a hydrodynamic diameter 20 +/- 4 nm, were delivered rat direct intracerebral inoculation or osmotic BBB disruption hypertonic mannitol. these was...
Journal Article Modelling drug-eluting stents Get access Sean McGinty, McGinty * Department of Mathematics and Statistics, University Strathclyde, 26 Richmond Street, Glasgow G1 1XH, UK *Corresponding author: rs.smcg@maths.strath.ac.uk Search for other works by this author on: Oxford Academic Google Scholar McKee, McKee Roger M. Wadsworth, Wadsworth Strathclyde Institute Pharmacy Biomedical Sciences, 27 Taylor G4 0NR, Christopher McCormick Mathematical Medicine Biology: A the IMA, Volume 28,...
In the dog, osmotic opening of blood-brain barrier (BBB) in posterior circulation via vertebral artery and anterior internal carotid was utilized to increase delivery three substances varying molecular weight central nervous system. The cerebrospinal fluid (CSF) concentration all agents dramatically increased after BBB opening. contrast methotrexate, Evans blue-albumin monoclonal antibody (MAb) concentrations CSF were 6-fold greater when given rather than Conversely, MAb brain parenchyma...
A mathematical model of a drug-eluting stent is proposed. The considers polymer region, containing the drug initially, and porous consisting smooth muscle cells embedded in an extracellular matrix. An analytical solution obtained for concentration both target interstitial region tissue terms release at interface between tissue. When are considered as coupled system, it can be shown, under certain assumptions, that satisfies Volterra integral equation which must solved numerically general....
Drug-eluting stents have significantly improved the treatment of coronary artery disease. They offer reduced rates restenosis compared with their bare-metal predecessors and are current gold standard in percutaneous interventions. been approved for use humans since 2002 yet, despite intensive research activity over past decade, drug release mechanism(s) uptake into arterial wall still poorly understood. While stent manufacturers focussed primarily on empirical methods, several mathematical...
In this paper we provide the first model of drug elution from polymer-free arterial drug-eluting stents. The generalised is capable predicting release a number systems including those that exhibit nanoporous, nanotubular and smooth surfaces. We derive analytical solutions which allow us to easily determine important parameters control release. Drug profiles are provided, offer design recommendations so profile may be tailored achieve desired outcome. models presented here not specific stents...
Increasing the delivery of therapeutic drugs to brain improves outcome for patients with tumors.Osmotic opening blood-brain barrier (BBB) can markedly increase drug delivery, but achieving consistent, good quality BBB disruption (BBBD) is essential. We evaluated four experiments compared our standard isoflurane/O (2) protocol improve and consistency BBBD tumor normal in a rat model. Success was assessed qualitatively large molecular weight marker Evans blue albumin quantitatively by...
Since the introduction of percutaneous coronary intervention (PCI) for treatment obstructive artery disease (CAD), patient outcomes have progressively improved. Drug eluting stents (DES) that employ anti-proliferative drugs to limit excess tissue growth following stent deployment proved revolutionary. However, restenosis and a need repeat revascularisation still occurs after DES use. Over last few years, computational models emerged detail bare metal (BMS), focusing primarily on...
Increasing the delivery of therapeutic drugs to brain improves outcome for patients with tumors.Osmotic opening blood-brain barrier (BBB) can markedly increase drug delivery, but achieving consistent, good quality BBB disruption (BBBD) is essential. We evaluated four experiments compared our standard isoflurane/O (2) protocol improve and consistency BBBD tumor normal in a rat model. Success was assessed qualitatively large molecular weight marker Evans blue albumin quantitatively by...
Pharmacokinetic parameters of iodinated monoclonal antibody (MAb) delivery to normal rat brain were examined. The mean cerebrovascular permeability-surface area (PA; permeability X capillary surface area) immunoglobulin M (IgM) MAb (mol wt 1,000,000) 10 min after infusion was 0.40 10(-6) S-1. When osmotic blood-brain barrier (BBB) disruption is utilized, the PA increased 8.36 Neither intravenous nor intracarotid administration significantly affected brain. However, BBB opening (P less than...
Drug-eluting stents are now routinely used in the treatment of acute coronary syndromes caused by artery disease. Whilst sustained release anti-proliferative drugs from these devices has greatly reduced need for repeat revascularisation procedures, this approach is not suitable all patients and appears to delay regrowth endothelium, necessitating use prolonged dual anti-platelet therapy. Although development more advanced stent platforms drug coatings produced modest improvements...
✓ This investigation was conducted to examine the immunosuppressive potential of phenytoin in vivo and document a correlation between therapy depressed lymphocyte responsiveness mitogens. It thought that phenytoin, most widely used anticonvulsant agent, may play some role immunosuppression seen brain-tumor patients. The effect on mitogen-stimulated function evaluated by tritiated ( 3 H)-thymidine incorporation nuclear size distribution. Lymphocytes from either phenytoin-treated or normal...