A5036923260- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Autophagy in Disease and Therapy
- Extracellular vesicles in disease
- Curcumin's Biomedical Applications
- Advanced Nanomaterials in Catalysis
- Advanced biosensing and bioanalysis techniques
- Phagocytosis and Immune Regulation
- Graphene and Nanomaterials Applications
- RNA Interference and Gene Delivery
- Bee Products Chemical Analysis
- Saffron Plant Research Studies
- Nigella sativa pharmacological applications
- Endoplasmic Reticulum Stress and Disease
- Electrospun Nanofibers in Biomedical Applications
- Structural Engineering and Vibration Analysis
- Skin Protection and Aging
- Phytochemicals and Antioxidant Activities
- Ultrasound and Hyperthermia Applications
- Hydrogels: synthesis, properties, applications
- Nuclear Receptors and Signaling
- Peroxisome Proliferator-Activated Receptors
- Urban Transport Systems Analysis
- Porphyrin and Phthalocyanine Chemistry
- Geotechnical and construction materials studies
Silesian University of Technology
2022-2024
University of Helsinki
2023
Chongqing University
2018-2021
Faculty (United Kingdom)
2020-2021
Universitas Muhammadiyah Malang
2021
Bioengineering Center
2020-2021
Atherosclerosis (AS), the underlying cause of most cardiovascular events, is one common causes human morbidity and mortality worldwide due to lack an efficient strategy for targeted therapy. In this work, we aimed develop ideal biomimetic nanoparticle AS Methods: Based on macrophage "homing" into atherosclerotic lesions cell membrane coating nanotechnology, nanoparticles (MM/RAPNPs) were fabricated with a (MM) surface rapamycin-loaded poly (lactic-co-glycolic acid) copolymer (PLGA) (RAPNPs)....
Abstract The development of nanomedicines provides new opportunities for the treatment atherosclerosis (AS) due to their great advantages such as improved drug solubility, enhanced bioavailability and reduced side effects. Despite these advantages, are still facing some challenges. problems remain in short circulation life, lack specific targeting poor release controllability. In order overcome shortages conventional nanomedicines, combination biomimetic strategy with smart nanoagents has...
Intimal hyperplasia caused by vascular injury is an important pathological process of many diseases, especially occlusive disease. In recent years, Nano-drug delivery system has attracted a wide attention as novel treatment strategy, but there are still some challenges such high clearance rate and insufficient targeting.In this study, we report biomimetic ROS-responsive MM@PCM/RAP nanoparticle coated with macrophage membrane. The membrane the innate "homing" capacity can superiorly regulate...
Trehalose has sparked considerable interest in a variety of pharmaceutical applications as well cryopreservation. Recently, there have been growing efforts the development trehalose delivery nanocarriers to address issue poor bioavailability trehalose. The majority strategies comprise physical entrapment trehalose, since its covalent, yet biolabile, conjugation is challenging. Here, we present research on trehalose-releasing nanogels, which was achieved through co-incorporation...
Parkinson’s disease (PD) is the second most prevalent age-related neurodegenerative disorder, clinically characterized by both motor and non-motor symptoms. A key hallmark of PD accumulation misfolded α-synuclein,...
Melittin (MLT), as a natural active biomolecule, can penetrate the tumor cell membrane to play role in cancer treatment and will attract more attention future development of antitumor drugs. The main component bee venom MLT was modified by introducing pH-sensitive amide bond between 2,3-dimethyl maleimide (DMMA) lysine (Lys) (MLT-DMMA). its corresponding peptide MLT-DMMA were used for biocompatibility validation. biomaterial characteristics tested MALDI-TOF MS, 1H NMR, IUPAC HPLC, viability,...
MicroRNAs (miRNAs) have great therapeutic potential; however, their delivery still faces huge challenges, especially given the short half-life of naked miRNAs due to rapid hydrolysis or inactivation by abundant nucleases in systemic circulation. Therefore, search for reliable miRNA systems is crucial. Nanogels are one more effective nanocarriers because they biocompatible and a high drug-loading capacity. In this study, acrylamide-based nanogels containing cationic groups redox-sensitive...
There would be over 600 million people living with diabetes by 2040 as predicted the World Health Organization. Diabetes is characterized raised blood sugar and insulin resistance. Insulin regulates influx of glucose into cell upregulating transporter type 4 (GLUT4) expression on plasma membrane. Besides, PPAR-γ also controls metabolism in adipose tissues. Curcuma mangga Val., denoted C. mangga, a native Indonesian medicinal plant that has many beneficial effects, including an antidiabetic...
Abstract The development of smart nanoagents that can respond to a specific stimulus has gained remarkable interest for treating various kinds diseases, including atherosclerosis. On the other hand, cell camouflaging strategy been considered as pivotal factor improve delivery stealthiness, biocompatibility, and biodegradability nanocarriers, resolving shortcomings PEGylation. In this study, reactive oxygen species (ROS)‐responsive 5‐aminolevulinic acid (ALA) prodrug nanostructures (ROSELLA)...
The use of smart nanocarriers that can modulate therapeutic release aided by biological cues prevent undesirable cytotoxicity caused the premature cytotoxic drugs during nanocarrier circulation. In this report, degradable based on pH/reduction dual-responsive nanogels were synthesized to encapsulate doxorubicin hydrochloride (DOX) and specifically boost DOX in conditions characteristic cancer microenvironment. Nanogels containing anionic monomer 2-carboxyethyl acrylate (CEA)...
Nanoplatforms have been used extensively as advanced carriers to enhance the effectiveness of drug delivery, mostly through passive aggregation provided by enhanced permeability and retention effect. Mechanical stimuli provide a robust strategy bolster delivery performance increasing accumulation nanoplatforms at lesion sites, facilitating on-demand cargo release providing theranostic aims. In this review, we focus on recent advances mechanoresponsive that can accomplish targeted subsequent...
Diabetes is a chronic disease caused by an imbalance of insulin release to the bloodstream in response excessive glucose influx, which causes hyperglycemia. White saffron (Curcuma mangga Val.), Indonesian aromatic spice, contains essential phytochemicals and has number potential health benefits. Here, we examined effects oral administration white powder (WSP): 1.5 4.5 g (WSP WSP 4.5) streptozotocin (STZ)-induced diabetic rats. was administered orally on daily basis for one month its...
Oxidative stress, the disrupted oxidation-reduction mechanism in our body, is caused by excessive exposure of free radicals and impaired antioxidant defenses that can accelerate skin aging. Antioxidants be obtained from nature, which are available widely therapeutic-rich plants, such as white saffron (Curcuma mangga Val., denoted C. mangga). Although many pieces evidence reveal contains an abundance phenolic compounds has antioxidative effects, its cosmeceutical potentials remain unclear....
The development of the tumor-targeting ability nanocarriers is paramount importance for gene delivery into tumor lesions as well to avoid biotoxicity. Here we report synthesis polyethyleneimine-fluorescein isothiocyanate-folic acid (PEI-FITC-FA) polymer, which could condense suppressor pp53 form nanocomplexes. These targeted nanocomplexes exhibited favorable physical properties including a small size <100 nm, exploiting enhanced permeability and retention effect by binding overexpressed FA...
This research focused on studying the effects of orally administered pressure-blanched white saffron antioxidative properties and lipid profiles wistar rats. White was blanched in autoclave for 2.5, 5, 7.5, 10 min at 100, 105, 110, 115, 120 °C, which are equivalent to 14.71, 17.53, 20.79, 24.54, 28.81 psia, respectively. A total 30 male rats aged four weeks were fed with a standard diet (N), oxidized peanut oil + unblanched (A), (B), (C), aquadest (NC), two after pre-treatment week. In vivo...
Abstract Atherosclerosis, cholesterol-driven plaque formation in arteries, is a complex multicellular disease which leading cause of vascular diseases. During the progression atherosclerosis, autophagic function impaired, resulting lipid accumulation-mediated foam cell formation. The stimulation autophagy crucial for recovery cellular recycling process. One potential inducers trehalose, naturally occurring non-reducing disaccharide. However, trehalose has poor bioavailability due to its...
Jembatan merupakan bagian dari infrastruktur jalan atau transportasi yang berfungsi untuk mendistribusikan manusia maupun barang, sehingga satu daerah dengan lainnya dapat terhubung dan tidak terisolasi. menghubungkan antara dua terpisah karena suatu rintangan seperti sungai, adanya jembatan, durasi lintas penyeberangan sungai dipercepat, mengurangi kemacetan lalu lintas, mempercepat distribusi logistik orang. Sebelum Dondang diresmikan pada tahun 2004, mode digunakan adalah sampan kayu...