A5103240245- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Extracellular vesicles in disease
- Pregnancy and preeclampsia studies
- Advanced Nanomaterials in Catalysis
- Birth, Development, and Health
- Phagocytosis and Immune Regulation
- Cell Adhesion Molecules Research
- Autophagy in Disease and Therapy
- Adipokines, Inflammation, and Metabolic Diseases
- Advanced biosensing and bioanalysis techniques
- Lipid Membrane Structure and Behavior
- Graphene and Nanomaterials Applications
- RNA Interference and Gene Delivery
- Antimicrobial Peptides and Activities
- Immune cells in cancer
- Atherosclerosis and Cardiovascular Diseases
- Cholesterol and Lipid Metabolism
- Nitric Oxide and Endothelin Effects
- Gut microbiota and health
- Peroxisome Proliferator-Activated Receptors
- Cardiovascular Health and Disease Prevention
- Inflammatory Bowel Disease
- Kruppel-like factors research
- Pregnancy and Medication Impact
Chongqing University
2017-2025
Chongqing Three Gorges University
2025
South China University of Technology
2024
Shanghai Tenth People's Hospital
2023
Tongji University
2023
Chongqing University of Technology
2022
Southwest Hospital
2020
China Agricultural University
2019-2020
Army Medical University
2020
First Affiliated Hospital of Soochow University
2015-2019
Atherosclerosis (AS), the underlying cause of most cardiovascular events, is one common causes human morbidity and mortality worldwide due to lack an efficient strategy for targeted therapy. In this work, we aimed develop ideal biomimetic nanoparticle AS Methods: Based on macrophage "homing" into atherosclerotic lesions cell membrane coating nanotechnology, nanoparticles (MM/RAPNPs) were fabricated with a (MM) surface rapamycin-loaded poly (lactic-co-glycolic acid) copolymer (PLGA) (RAPNPs)....
Nanoparticles (NPs) modified by cell membranes represent an emerging biomimetic platform that can mimic the innate biological functions resulting from various in systems. researchers focus on constructing membrane camouflaged NPs using a wide variety of cells, such as red blood (RBC), macrophages and cancer cells. Cell (CMNPs) inherit composition membranes, including specific receptors, antigens, proteins, for target delivering to tumor, escaping immune clearance, prolonging circulation...
Abstract Ulcerative colitis (UC), affecting millions of patients worldwide, is associated with disorders the gut microbiota. Probiotics‐based therapy positively regulating community structure microbiota regarded as an efficient intervention for UC. However, oral probiotics delivery restricted by limited bioactivity, short retention time, complex pathological condition, and single therapeutic efficacy. Here, a bioengineered probiotic decorated multifunctional prodrug coating constructed to...
Abstract Biomimetic cell membrane camouflaged technology has drawn extensive attention as a feasible and efficient way to realize the biological functions of nanoparticles from parent cells. As burgeoning nanotherapeutic, right‐side‐out orientation self‐assembly pathological dependent “on‐demand” cargo release nanocarriers remarkably limit further development for practical applications. In present study, spontaneously right‐side‐out‐orientated coupling‐driven ROS‐sensitive nanotherapeutic...
A disorder of cholesterol homeostasis is one the main initiating factors in progression atherosclerosis (AS). Metabolism and removal excess facilitates prevention foam cell formation. However, failure treatment with drugs (e.g. methotrexate, MTX) to effectively regulate disease may be related limited drug bioavailability rapid clearance by immune system. Thus, based on inflammatory lesion "recruitment" properties macrophages, MTX nanoparticles (MTX NPs) camouflaged macrophage membranes...
Abstract Multifunctional nanomedicines have been used in atherosclerosis theranostics. Herein, phosphatidylserine‐specific peptide CLIKKPF‐functionalized carbon‐dots nanozymes (pep‐CDs) are reported for specific and efficient noninvasive theranostic of atherosclerosis. Surprisingly, pep‐CDs discovered to not only inherit the inherent properties carbon dots (CDs), including deep‐red fluorescence emission, photoacoustic response, superoxide dismutase‐like antioxidant, anti‐inflammatory...
Intimal hyperplasia caused by vascular injury is an important pathological process of many diseases, especially occlusive disease. In recent years, Nano-drug delivery system has attracted a wide attention as novel treatment strategy, but there are still some challenges such high clearance rate and insufficient targeting.In this study, we report biomimetic ROS-responsive MM@PCM/RAP nanoparticle coated with macrophage membrane. The membrane the innate "homing" capacity can superiorly regulate...
Extracellular vesicles (EVs) are increasingly used as delivery vehicles for drugs and bioactive molecules, which usually require intravascular administration. The endothelial cells covering the inner surface of blood vessels susceptible to shear stress flow. Few studies demonstrate interplay red cell-derived EVs (RBCEVs) cells. Thus, phagocytosis by vascular during flow needs be elucidated. In this study, extracellular were constructed investigate cell in vitro animal models. Results showed...
For atherosclerosis (AS) management, a therapeutic drug intervention is the most widely used strategy. However, there are some problems such as low location specificity, high intake, and side effects. Nanomedicine can prolong half-life of solubilization, reduce toxic effects, improve distribution objects. Herein, to overcome challenges, an erythrocyte-based "plug play" nanoplatform was developed by incorporating vascular cell adhesion molecule-1 (VCAM-1) targeting acid stimulus...
A ZIF-8 nanoplatform decorated with HA has been developed to selectively deliver a drug into atherosclerotic plaques, and subsequently enhance local cargo release under acid stimuli for efficient safe anti-atherosclerosis therapy.
The preparation of right-side-out-orientated coupling-driven ROS-sensitive nanoparticles on the inner leaflet cell membrane for positively regulating phenotypic conversion in atherosclerosis.
Atherosclerosis (AS) management typically relies on therapeutic drug interventions, but these strategies have drawbacks, including poor site specificity, high systemic intake, and undesired side effects. The field of cell membrane camouflaged biomimetic nanomedicine offers the potential to address challenges thanks its ability mimic natural properties membranes that enable enhanced biocompatibility, prolonged blood circulation, targeted delivery, evasion immune recognition, ultimately...
Atherosclerotic plaques exhibit high cholesterol deposition and oxidative stress resulting from reactive oxygen species (ROS). These are the major components in main pro-inflammatory factor. Therefore, it is crucial to develop an effective therapeutic strategy that can simultaneously address multiple factors via removing inhibiting overaccumulated ROS. In this study, we constructed macrophage membrane-encapsulated biomimetic nanoparticles (MM@DA-pCD@MTX), which not only alleviate at plaque...
Background: TET1 has been implicated in regulating inflammation and cardiovascular disease, but a newly discovered short isoform of (termed TET1s) exhibits higher expression adult tissues than full-length TET1. However, the precise role disease remains undefined. Methods Results: Based on TET1-/- knockout mice (with deletion both TET1s ) TET1cs/cs only TET1), we found that resulted more serious atherosclerotic lesions whole aorta ApoE-/- background fed high-fat diet. Atherosclerotic with Oil...
To determine the role of MYL4 regulation lysosomal function and its disturbance in fibrotic atrial cardiomyopathy. We have previously demonstrated that atrial-specific essential light chain protein is required for contractile, electrical, structural integrity. mutation/dysfunction leads to fibrosis, standstill, dysrhythmia. However, underlying pathogenic mechanisms remain unclear. Rats subjected knock-in a mutant (p.E11K) developed Proteome analysis single-cell RNA sequencing indicate...
The formation of atherosclerosis is the root cause various cardiovascular diseases (CVDs). Therefore, effective CVD interventions call for precise identification plaques to aid in clinical treatment such diseases. Herein, a reactive oxygen species (ROS)-responsive sequentially targeted fluorescent probe developed atherosclerotic plaque recognition. An aggregation-induced emission active fluorophore linked maleimide (polyethylene glycol) hydroxyl with ROS-responsive cleavable bond, which...
Abstract Hypoxia during pregnancy could affect development of fetuses as well cardiovascular systems in the offspring. This study was first to demonstrate influence and related mechanisms prenatal hypoxia (PH) on renal interlobar arteries (RIA) 5-month-old male rat Following chronic pregnancy, phenylephrine induced significantly higher pressor responses greater vasoconstrictions Nitric oxide mediated vessel relaxation altered RIA. Phenylephrine-stimulated free intracellular calcium RIA PH...
Abstract Theranostic applications in atherosclerosis plaque microenvironment‐triggered nanoplatforms are significantly compromised by the complex synthesis procedure, non‐specific distribution, and limited therapeutic function. Therefore, development of a facile feasible method to construct pathology‐based stimuli‐responsive nanoplatform with satisfactory theranostic performance remains demanding highly anticipated goal. Herein, novel class multifunctional supra‐carbon dots (CDs), denoted as...
Cardiovascular and cerebrovascular diseases (CCVDs) remain the leading cause of human death worldwide, therefore their early, highly sensitive diagnosis effective treatment are key to reducing related mortality. With the...
Abstract: Further specific target-ability development of biodegradable nanocarriers is extremely important to promote their security and efficiency in antitumor drug-delivery applications. In this study, a facilely prepared poly(lactic- co -glycolic acid) (PLGA)–polyethylene glycol (PEG)–folic acid (FA) copolymer was able self-assemble into nanoparticles with favorable hydrodynamic diameters around 100 nm negative surface charge aqueous solution, which expected enhance intracellular drug...