A5101609863- Nanoparticle-Based Drug Delivery
- Cell Adhesion Molecules Research
- Conducting polymers and applications
- Advanced Nanomaterials in Catalysis
- Bee Products Chemical Analysis
- Wound Healing and Treatments
- Innovative Microfluidic and Catalytic Techniques Innovation
- Angiogenesis and VEGF in Cancer
- Advanced Photocatalysis Techniques
- Advanced Sensor and Energy Harvesting Materials
- Protease and Inhibitor Mechanisms
- Advanced biosensing and bioanalysis techniques
- Nanoplatforms for cancer theranostics
- Kruppel-like factors research
- Cerebrovascular and Carotid Artery Diseases
- Ultrasound and Hyperthermia Applications
- Advanced Biosensing Techniques and Applications
- Apelin-related biomedical research
- Cancer Cells and Metastasis
- Zebrafish Biomedical Research Applications
- Soil, Finite Element Methods
- Advanced battery technologies research
- Moringa oleifera research and applications
- Hemostasis and retained surgical items
- Copper-based nanomaterials and applications
Chongqing University
2007-2025
Chongqing University of Technology
2025
Chengdu Medical College
2024
Qingdao University of Science and Technology
2019-2023
Bioengineering Center
2018-2021
Faculty (United Kingdom)
2020-2021
Rationale: Atherosclerosis is characterized by lipid accumulation, plaque formation, and artery stenosis.The pharmacological treatment a promising therapy for atherosclerosis, but this approach faces major challenges such as targeted drug delivery, controlled release, non-specific clearance.Methods: Based on the finding that cathepsin k (CTSK) enzyme enriched in atherosclerotic lesions, we constructed an integrin αvβ3 CTSK-responsive nanoparticle to control release of rapamycin (RAP)...
Supplemental Bifidobacterium has been shown to aid in the prevention, alleviation, and treatment of inflammatory bowel disease (IBD), but progression mechanisms are largely unstudied, partly because a lack appropriate models. In vitro human gut models must accurately recreate oxygen concentration gradients consistent with those vivo mimic gene expression, metabolism, host-microbiome interactions. A non-equipment-intensive inexpensive method for constructing gut-on-a-chip physiological...
Effective treatment of glioma and other central nervous system (CNS) diseases is hindered by the presence blood-brain barrier (BBB). A novel nano-delivery vehicle composed PLGA-lysoGM1/DOX micelles was developed to cross BBB for CNS treatment. We have shown that doxorubicin (DOX) as a model drug encapsulated in PLGA-lysoGM1 can achieve up 3.8% loading efficiency 61.6% encapsulation orthogonal test design. Our vitro experiments demonstrated had slow sustainable release under physiological...
The preparation of right-side-out-orientated coupling-driven ROS-sensitive nanoparticles on the inner leaflet cell membrane for positively regulating phenotypic conversion in atherosclerosis.
Abstract Mechanical stimulation plays a crucial role in numerous biological activities, including tissue development, regeneration, and remodelling. Understanding how cells respond to their mechanical microenvironment is vital for investigating mechanotransduction with adequate spatial temporal resolution. Cell force sensing—also known as mechanosensation or mechanotransduction—involves transmission through the cytoskeleton mechano-chemical signalling. Insights into cell-extracellular matrix...
The rational utilization of ROS is key to treating infected wounds. Exogenous can destroy bacterial structures, quickly kill bacteria, and inhibit secondary infections. However, excess at the wound will cause a inflammatory response. Acute infections exacerbate this damage by increasing endogenous ROS, complicating maintenance homeostasis. Therefore, regulating balance production scavenging in wounds has emerged as promising strategy for treatment. Conventional balancing platforms are mostly...
Recent studies have focused on capillary pruning in various organs and species. However, the way which large-diameter vessels are pruned remains unclear. Here we show that of zebrafish caudal vein (CV) from ventral capillaries CV plexus different transgenic embryos is driven by endothelial cell (EC) rearrangement, involves EC nucleus migration, junction remodeling, actin cytoskeleton remodeling. Further observation reveals a growing difference blood flow velocity between two embryos. With...
Nitric oxide (NO) is an exceptional endogenous biological gas that mediates and regulates physiological pathological processes in the human body. However, its synthesis process impaired during athero-progression formation. Hence, a strategy to boost NO production target endothelial nitric synthase (eNOS) crucial intriguing atherosclerosis (AS) management. Herein, we prepare L-arginine (LA) lovastatin (LV) co-loaded PLGA nanomedicine achieve sustainable release for enhancing production. The...
Conductive hydrogel films, as integral elements of flexible sensors, hold promising applications across a diverse range fields. However, their cost-effective and straightforward production, ensuring both excellent mechanical properties conductivity, remains formidable challenge. In our research, we developed multifunctional conductive film (mAu/PDPPy) using freeze‒thaw cycling-annealing method. This process applies cycling to reorganize the cross-linking structure improve crystallinity PVA...
A bioactive material based on mussel adhesive protein Mfp-5 fused with VE-cadherin extracellular domain specifically enhances the adhesion of endothelial cells.
At present, cardiovascular and cerebrovascular diseases seriously threaten human life health, the development of nanodrug delivery systems has brought about a turnaround for traditional drug treatments, with nanoparticles being precisely targeted to improve bioavailability.In addition, surface modification can prolong blood circulation time enhance targeting ability.The application cell membrane-coated further improves their biocompatibility active ability, providing new hope treatment...
Without intervention, the natural wound healing process can often result in scarring, which have detrimental effects on both physical and mental well-being of patients. Therefore, it is crucial to develop biomaterials that promote without scarring. Regulating Yes-associated protein-1/PDZ-binding motif (YAP/TAZ) signaling pathway possible reduce excessive fibrosis fibroblasts proliferation vascular endothelial cells, ultimately impacting scar formation. Arsenic trioxide (ATO), an ancient drug...
High-motile fish keratocytes exhibited integrin-mediated forces ranging from 44 to 100 pN, whereas low-motile 3T3L1 and NRK cells generated exceeding pN.