A5066855201- SARS-CoV-2 and COVID-19 Research
- Pneumonia and Respiratory Infections
- Bacterial Infections and Vaccines
- Animal Virus Infections Studies
- COVID-19 Clinical Research Studies
- Influenza Virus Research Studies
- Viral gastroenteritis research and epidemiology
- vaccines and immunoinformatics approaches
- HIV Research and Treatment
- Vaccine Coverage and Hesitancy
- RNA Interference and Gene Delivery
- Respiratory viral infections research
- Adenosine and Purinergic Signaling
- Streptococcal Infections and Treatments
- Gallbladder and Bile Duct Disorders
- Viral Infections and Immunology Research
- RNA regulation and disease
- Stress Responses and Cortisol
- Wound Healing and Treatments
- Retinoids in leukemia and cellular processes
- Protease and Inhibitor Mechanisms
- Enzyme Production and Characterization
- Immunotherapy and Immune Responses
- Protein Hydrolysis and Bioactive Peptides
- Monoclonal and Polyclonal Antibodies Research
Jilin Medical University
2021-2024
Jilin University
2003-2024
Chongqing Medical University
2024
Beijing VDJBio (China)
2014-2024
China National Center for Biotechnology Development
2021
Jiangsu Provincial Center for Disease Control and Prevention
2021
National Institute for Viral Disease Control and Prevention
2021
National Institutes for Food and Drug Control
2021
Beike Biotechnology (China)
2021
Northeastern University
2019
Amyotrophic lateral sclerosis (ALS) is characterized by the progressive loss of motor neurons, unknown etiology. Previous studies showed reverse transcriptase in serum ALS patients at levels comparable to human immunodeficiency virus-infected patients; however, source and significance retroviral elements uncertain.Expression a endogenous retrovirus (HERV-K) was determined autopsy brain tissue with compared control populations real-time polymerase chain reaction followed sequencing amplified...
Abstract Background: The significant morbidity and mortality resulted from the infection of a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) call for urgent development effective safe vaccines. We report immunogenicity safety an inactivated SARS-CoV-2 vaccine, KCONVAC, in healthy adults. Methods: Phase 1 phase randomized, double-blind, placebo-controlled trials KCONVAC were conducted Chinese adults aged 18 to 59 years. participants trial randomized receive two doses, one each...
Pneumococcal disease is caused by Streptococcus pneumoniae , including pneumonia, meningitis and sepsis. Capsular polysaccharides (CPSs) have been shown as effective antigens to stimulate protective immunity against pneumococcal disease. A major step in the production of vaccines prepare CPSs that meet strict quality standards immunogenicity safety. The impurities come from bacterial proteins, nucleic acids cell wall polysaccharides. Traditionally, impurity level refined reduced optimization...
Vaccination has substantially reduced the morbidity and mortality of bacterial diseases, but mechanisms vaccine-elicited pathogen clearance remain largely undefined. We report that immunity against invasive bacteria mainly operates in liver. In contrast to current paradigm migrating phagocytes execute blood-borne pathogens, we found are captured killed liver vaccinated host via various immune depend on protective potency vaccine. Vaccines with relatively lower degrees protection only...
SARS-CoV-2 and SARS-CoV are genetically related coronavirus share the same cellular receptor ACE2. By replacing VSV glycoprotein with spikes (S) of SARS-CoV, we generated two replication-competent recombinant viruses, rVSV-SARS-CoV-2 rVSV-SARS-CoV. Using wild-type human ACE2 (hACE2) knock-in mouse models, found a single dose rVSV-SARS-CoV could elicit strong humoral immune response via both intranasal (i.n.) intramuscular (i.m.) routes. Despite high genetic similarity between no obvious...
The rational utilization of ROS is key to treating infected wounds. Exogenous can destroy bacterial structures, quickly kill bacteria, and inhibit secondary infections. However, excess at the wound will cause a inflammatory response. Acute infections exacerbate this damage by increasing endogenous ROS, complicating maintenance homeostasis. Therefore, regulating balance production scavenging in wounds has emerged as promising strategy for treatment. Conventional balancing platforms are mostly...
Streptococcus pneumoniae is a pathogenic bacterium that causes infections such as pneumonia, meningitis, otitis media, and bacteremia. The prevention of pneumococcal disease by vaccination has become more urgent due to increased antibiotic resistance. Pneumococcal capsular polysaccharides (CPS) are effective vaccine antigens stimulate the host produce protective antibodies. S . serotype 14 one most prevalent types in Latin America across world. However, yield S. CPS from existing...
Brucellosis, caused by Brucella, is one of the most common zoonosis. However, there still no vaccine for human use. Although some live attenuated vaccines have been approved animals, protection effect not ideal. In this study, we developed a dual-antigen nanoconjugate containing both polysaccharide and protein antigens against Brucella. First, antigenic was covalently coupled to outer membrane Omp19 using glycan coupling technology, then it successfully loaded on nano-carrier through...
The reliability-based sensitivity analysis requires to recursively evaluate a multivariate structural model for many failure probability levels. This is in general computationally intensive task due irregular integrations used define the probability. In this regard, performance function first approximated by using multiplicative dimensional reduction method paper, and an approximation index derived based on principle of maximum entropy fractional moment. Three examples literature are...
Control of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic needs effective vaccines.In a phase randomized, double-blind, placebo-controlled trial, 500 adults aged 18-59 years or ≥60 were randomized in 2:2:1 ratio to receive 3 doses 5 μg 10 SARS-CoV-2 inactivated vaccine, placebo separated by 28 days. Adverse events (AEs) recorded through day after each dosing. Live virus pseudovirus neutralizing antibodies, and receptor binding domain immunoglobulin G (RBD-IgG) antibody...
Abstract Intranasal (i.n.) vaccines can induce mucosal and systemic immunity against respiratory pathogens. Previously, we demonstrated that the recombinant vesicular stomatitis virus (rVSV)‐based COVID‐19 vaccine rVSV‐SARS‐CoV‐2, with poor immunogenicity via intramuscular route (i.m.), is more suitable for i.n. administration in mice nonhuman primates. Here, found rVSV‐SARS‐CoV‐2 Beta variant was immunogenic than wild‐type strain other variants of concern (VOCs) golden Syrian hamsters....