A5100747153- Metabolism, Diabetes, and Cancer
- Spaceflight effects on biology
- Bacterial Infections and Vaccines
- Plant Molecular Biology Research
- Pancreatic function and diabetes
- Adipose Tissue and Metabolism
- Photosynthetic Processes and Mechanisms
- Plant Reproductive Biology
- Pneumonia and Respiratory Infections
- Tea Polyphenols and Effects
- Cancer-related molecular mechanisms research
- Plant nutrient uptake and metabolism
- Genomics and Phylogenetic Studies
- Genetics, Aging, and Longevity in Model Organisms
- Plant Gene Expression Analysis
- Cancer, Hypoxia, and Metabolism
- Fungal Biology and Applications
- Cocoa and Sweet Potato Agronomy
- Plant-Microbe Interactions and Immunity
- Autophagy in Disease and Therapy
- Bacillus and Francisella bacterial research
- Plant biochemistry and biosynthesis
- Bacterial biofilms and quorum sensing
- Chromosomal and Genetic Variations
- Circular RNAs in diseases
Yunnan Agricultural University
2014-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
National Institutes for Food and Drug Control
2010-2025
North China University of Science and Technology
2016-2024
Hebei Normal University of Science and Technology
2023-2024
Southwest University
2020-2022
Ghent University
2022
VIB-UGent Center for Plant Systems Biology
2022
Peking University
2018-2021
Peking University Cancer Hospital
2018-2021
This study focuses on the effects of short-term [22 s, parabolic flight campaign (PFC)] and long-term (10 d, Shenzhou 8 space mission) real microgravity changes in cytokine secretion gene expression patterns poorly differentiated thyroid cancer cells. FTC-133 cells were cultured a random positioning machine (RPM) for 10 to evaluate differences between simulated microgravity. Multianalyte profiling was used 128 secreted cytokines. Microarray analysis revealed 63 significantly regulated...
Macrofungus is defined as the fungus that grows an observable sporocarp. The sporocarps of many species are commonly called mushrooms and consumed by people all around world food and/or medicine. Most macrofungi belong to divisions Basidiomycetes Ascomycetes, which estimated contain more than 80,000 in total. We report draft genome assemblies (83 7 Ascomycetes species) based on Illumina sequencing. sizes these ranged from 27.4 Mb (Hygrophorus russula) 202.2 MB (Chroogomphus rutilus). numbers...
Plant Hormone Gene Database (PHGD) database platform construction pipeline. First, we collected all reported hormone-related genes in the model plant Arabidopsis thaliana, and combined with existing experimental background, mapped hormone–gene interaction network to provide a blueprint. Next, 469 high-quality genomes. Then, bioinformatics was used identify these plants. Finally, genetic data were programmed be stored website PHGD built. divided into eight modules, namely Home, Browse,...
MicroRNAs (miRNAs) are endogenous small RNAs that 18–23 nucleotides long. Recently, plasma miRNAs were reported to be sensitive and specific biomarkers of various pathological conditions. In the present study, we focused on miR-210, which is known induced by hypoxia might therefore an excellent biomarker for congestive heart failure. Plasma miR-210 levels expression in mononuclear cells skeletal muscles elevated Dahl salt-sensitive rats with We also assessed patients The NYHA III IV failure...
Extracellular matrix proteins, adhesion molecules, and cytoskeletal proteins form a dynamic network interacting with signalling molecules as an adaptive response to altered gravity. An important issue is the exact differentiation between real microgravity responses of cells or cellular reactions hypergravity and/or vibrations. To determine effects on human cells, we used four DLR parabolic flight campaigns focused short-term (22 s), (1.8 g), vibrations ML-1 thyroid cancer cells. No signs...
This study focused on the effects induced by a random positioning machine (RPM) FTC-133 thyroid cancer cells and evaluated signaling elements involved in 3-dimensional multicellular tumor spheroid (MCTS) formation. The were cultured RPM, device developed to simulate microgravity, under static 1-g conditions. After 24 h MCTSs swimming culture supernatants found, addition growth of adherent (AD) cells. Cells grown RPM showed higher levels NF-κB p65 protein apoptosis than controls, result also...
This study focused on the effects of short-term microgravity (22 s) gene expression and morphology endothelial cells (ECs) evaluated gravisensitive signaling elements. ECs were investigated during four German Space Agency (Deutsches Zentrum für Luft- und Raumfahrt) parabolic flight campaigns. Hoechst 33342 acridine orange/ethidium bromide staining showed no signs cell death in after 31 parabolas (P31). Gene array analysis revealed 320 significantly regulated genes first parabola (P1) P31....
Maca (Lepidium meyenii Walp, 2n = 8x 64), belonging to the Brassicaceae family, is an economic plant cultivated in central Andes sierra Peru (4000-4500 m). Considering that rapid uplift of occurred 5-10 million years ago (Ma), evolutionary question arises regarding how plants such as maca acquire high-altitude adaptation within a short geological period. Here, we report high-quality genome assembly maca, which two closely spaced maca-specific whole-genome duplications (WGDs; ∼6.7 Ma) were...
The drumstick tree (Moringa oleifera Lam.) is a perennial crop that has gained popularity in certain developing countries for its high-nutrition content and adaptability to arid semi-arid environments. Here we report high-quality draft genome sequence of M. oleifera. This assembly represents 91.78% the estimated size contains 19,465 protein-coding genes. Comparative genomic analysis between related woody plant genomes helps clarify general evolution this species, while identification several...
Tissue engineering of chondrocytes on a Random Positioning Machine (RPM) is new strategy for cartilage regeneration. Using three-dimensional RPM, device designed to simulate microgravity Earth, we investigated the early effects RPM exposure human six different donors after 30 min, 2 h, 4 16 and 24 h compared results with corresponding static controls cultured under normal gravity conditions. As little as min resulted in increased expression several genes responsible cell motility, structure...
Abstract There have been few reports about the possible toxic effects of titanium dioxide (TiO 2 ) nanoparticles on endocrine system. We explored oral administration to mice anatase TiO (0, 64 and 320 mg kg –1 body weight per day control, low‐dose high‐dose groups, respectively, 7 days week for 14 weeks). were characterized by scanning transmission electron microscopy (TEM) dynamic light scattering (DLS), their physiological distribution was investigated inductively coupled plasma....
Multicellular tumor spheroids (MCTS) formed scaffold-free under microgravity are of high interest for research and medicine. Their formation mechanism can be studied in space real or on Earth using ground-based facilities (GBF), which simulate microgravity. On Earth, these experiments more cost-efficient easily performable. However, each GBF might exert device-specific altered superimposingly gravity-dependent effects the cells. FTC-133 human thyroid cancer cells were cultivated a 2D...
In this study we focused on gravity-sensitive proteins of two human thyroid cancer cell lines (ML-1; RO82-W-1), which were exposed to a 2D clinostat (CLINO), random positioning machine (RPM) and normal 1g-conditions. After three (3d)- or seven-day-culture (7d) the devices, found both types growing three-dimensionally within multicellular spheroids (MCS) also cells remaining adherent (AD) culture flask, while 1g-control cultures only formed monolayers, unless bottom dish was covered by...
Cold stress profoundly affects plant growth and development is a key factor affecting the geographic distribution evolution of plants. Plants have evolved adaptive mechanisms to cope with cold stress. Here, through genomic analysis Arabidopsis, three Brassica species 17 other representative species, we found that both cold-related genes (CRGs) their collinearity were preferentially retained after polyploidization followed by genome instability, while genome-wide gene sets exhibited variety...
Species belonging to the order Ranunculales have attracted much attention because of their phylogenetic position as a sister group all other eudicot lineages and ability produce unique yet diverse benzylisoquinoline alkaloids (BIAs). The Papaveraceae family in is often used model system for studying BIA biosynthesis. Here, we report chromosome-level genome assembly Corydalis tomentella, species Fumarioideae, one two subfamilies Papaveraceae. Based on comparisons sequenced Ranunculalean...
Flowering is one of the most important biological phenomena in plant kingdom, which not only has ecological significance, but also substantial horticultural ornamental value. In this study, we undertook an exhaustive review advancements our understanding flowering genes. We delved into identification and conducted comparative analyses genes across virtually all sequenced angiosperm genomes. Furthermore, established extensive atlas, encompassing a staggering 183 720 eight pathways, along with...
Abstract The auxin response factor (ARF) and auxin/indole-3-acetic acid (Aux/IAA) family of genes are central components the signaling pathway play essential roles in plant growth development. Their large-scale analysis evolutionary trajectory origin currently not known. Here, we identified corresponding ARF Aux/IAA members performed a by scanning 406 genomes. results showed that gene families originated from charophytes. sequences were more conserved than sequences. Dispersed duplications...
The P2X(7) receptor is a ligand-gated ion channel, and genetic variations in the gene significantly affect blood pressure. expression associated with renal injury inflammatory diseases. Uninephrectomized wild-type (WT) P2X(7)-deficient (P2X(7) KO) mice were subcutaneously implanted deoxycorticosterone acetate (DOCA) pellets fed an 8% salt diet for 18 days. Their pressure was assessed by telemetry system. placed metabolic cages, urine collected 24 h to assess function. After days of DOCA-salt...
The BES1 gene family, an important class of plant-specific transcription factors, play key roles in the BR signal pathway plants, regulating various development processes. Until now, there has been no comprehensive analysis family Brassica napus, and a cross-genome exploration their origin, copy number changes, functional innovation plants was also not available. We identified 28 genes B. napus from its two subgenomes (AA CC). found that 71.43% them were duplicated tetraploidization,...
Increased transcriptional levels of genes encoding antioxidant enzymes play important protective roles in coping with excessive accumulation reactive oxygen species (ROS) plants exposed to various abiotic stresses. To fully elucidate different evolutions and functions ROS-scavenging enzymatic genes, we isolated iron superoxide dismutase (FeSOD), dehydroascorbate reductase (DHAR) monodehydroascorbate (MDHAR) from white clover for the first time subsequently tested dynamic expression profiles...