A5077244358- Spaceflight effects on biology
- Planetary Science and Exploration
- Space Exploration and Technology
- Magnetic and Electromagnetic Effects
- Light effects on plants
- Plant Molecular Biology Research
- Space Science and Extraterrestrial Life
- Spacecraft Design and Technology
- Wastewater Treatment and Nitrogen Removal
- Genetics, Aging, and Longevity in Model Organisms
- Protist diversity and phylogeny
- Algal biology and biofuel production
- Cellular Mechanics and Interactions
- Radiation Therapy and Dosimetry
- Constructed Wetlands for Wastewater Treatment
- Plant Reproductive Biology
- Environmental Science and Water Management
- Automotive and Human Injury Biomechanics
- Agriculture Sustainability and Environmental Impact
- Greenhouse Technology and Climate Control
- Biofield Effects and Biophysics
- Circadian rhythm and melatonin
- Marine and fisheries research
- Cancer, Hypoxia, and Metabolism
- Cosmology and Gravitation Theories
Deutsches Zentrum für Luft- und Raumfahrt e. V. (DLR)
2014-2024
Institute of Air Handling and Refrigeration
2021
Institute of Aviation Medicine
2011
University of Bonn
2004-2005
Artificial intelligence (AI) has smoothly penetrated in a number of monitoring and control applications including agriculture. However, research efforts toward low-power sensing devices with fully functional AI on board are still fragmented. In this article, we present an embedded system enriched the AI, ensuring continuous analysis situ prediction growth dynamics plant leaves. The solution is grounded graphics processing unit (GPU) able to run neural network-based board. We use recurrent...
Extracellular matrix proteins, adhesion molecules, and cytoskeletal proteins form a dynamic network interacting with signalling molecules as an adaptive response to altered gravity. An important issue is the exact differentiation between real microgravity responses of cells or cellular reactions hypergravity and/or vibrations. To determine effects on human cells, we used four DLR parabolic flight campaigns focused short-term (22 s), (1.8 g), vibrations ML-1 thyroid cancer cells. No signs...
This study focused on the effects of short-term microgravity (22 s) gene expression and morphology endothelial cells (ECs) evaluated gravisensitive signaling elements. ECs were investigated during four German Space Agency (Deutsches Zentrum für Luft- und Raumfahrt) parabolic flight campaigns. Hoechst 33342 acridine orange/ethidium bromide staining showed no signs cell death in after 31 parabolas (P31). Gene array analysis revealed 320 significantly regulated genes first parabola (P1) P31....
Ground-based facilities, such as clinostats and random positioning machines aiming at simulating microgravity conditions, are tools to prepare space experiments identify gravity-related signaling pathways. A prerequisite is that the facilities operated in an appropriate manner potentially induced non-gravitational effects, shearing forces, have be taken into account. Dinoflagellates, here
In this study we focused on gravity-sensitive proteins of two human thyroid cancer cell lines (ML-1; RO82-W-1), which were exposed to a 2D clinostat (CLINO), random positioning machine (RPM) and normal 1g-conditions. After three (3d)- or seven-day-culture (7d) the devices, found both types growing three-dimensionally within multicellular spheroids (MCS) also cells remaining adherent (AD) culture flask, while 1g-control cultures only formed monolayers, unless bottom dish was covered by...
Tissue engineering of chondrocytes on a Random Positioning Machine (RPM) is new strategy for cartilage regeneration. Using three-dimensional RPM, device designed to simulate microgravity Earth, we investigated the early effects RPM exposure human six different donors after 30 min, 2 h, 4 16 and 24 h compared results with corresponding static controls cultured under normal gravity conditions. As little as min resulted in increased expression several genes responsible cell motility, structure...
Abstract Early processes underlying plant gravity sensing were investigated in rhizoids of Chara globularis under microgravity conditions provided by parabolic flights the A300-Zero-G aircraft and sounding rockets. By applying centrifugal forces during phases rocket flights, lateral accelerations 0.14g, but not 0.05g, resulted a displacement statoliths. Settling statoliths onto subapical plasma membrane initiated gravitropic response. Since actin controls positioning restricts sedimentation...
Background: Endothelial cells (EC) cultured under altered gravity conditions show a cytoskeletal disorganization and differential gene expression (short-term effects), as well apoptosis in adherently growing EC or formation of tubular 3D structures (long-term effects). Methods: Investigating short-term effects real microgravity, we exposed to parabolic flight maneuvers analysed them on both protein transcriptional level. The hypergravity vibration were studied separately. Results: Pan-actin...
Human space exploration needs stable life support systems for the supply of oxygen, water and food each human explorer due to long term missions. The most promising approach building is a combination physico-chemical biological systems. These hybrid combine reliability sustainability Also disadvantages, which are finite resources imperfect systems, mutually balanced. To improve different may stabilize whole during operations. satellite mission Eu:CROPIS (Euglena gracilis: Combined...
Abstract Plant roots are among most intensively studied biological systems in gravity research. Altered induces asymmetric cell growth leading to root bending. Differential distribution of the phytohormone auxin underlies responses gravity, being coordinated by efflux transporters from PIN family. The objective this study was compare early transcriptomic changes Arabidopsis thaliana wild type, and pin2 pin3 mutants under parabolic flight conditions correlate these distribution. Parabolic...
Abstract To realize long-term manned space missions, e.g. to Mars, some important questions about pharmacology under conditions of different gravity will have be answered ensure safe usage pharmaceuticals. Experiments on the International Space Station showed that pharmacokinetics drugs are changed in microgravity. On Earth, it is well known incorporation substances into cellular membranes depends membrane fluidity, therefore finding fluidity dependent possibly has effects pharmacodynamics...
Clinostats and Random Positioning Machines (RPMs) are valuable devices for microgravity simulations in order to study fundamental gravity-dependent mechanisms on ground preparation space flights. Both have different modes of operation, which be carefully considered comprehensively discussed with respect their potential impact the quality (simulated) microgravity. Here, we used well-studied oxidative burst reaction immune cell (macrophage) model system, compare clinorotation random...
During spaceflight, humans experience a variety of physiological changes due to deviations from familiar earth conditions. Specifically, the lack gravity is responsible for many effects observed in returning astronauts. These impairments can include structural as well functional brain and decline cognitive performance. However, underlying mechanisms remain elusive. Alterations neuronal activity play central role mental disorders altered transmission may also lead diminished human performance...
It is known that exposing cell lines in vitro to parabolic flights changes their gene expression and protein production patterns. Parabolic spaceflight general are accompanied by transient hypergravity vibration, which may impact the cells therefore, have be considered too. To estimate possible of we investigated effects these forces separately using dedicated ground-based facilities. We placed follicular thyroid ML-1 CGTH W-1 cancer a specific centrifuge (MuSIC Multi Sample Incubator...
Planetary habitation requires technology to maintain natural microbial processes, which make nutrients from biowaste available for plant cultivation. This study describes a 646 day experiment, in trickling filters were monitored their ability mineralize nitrogen when loaded with artificial urine solutions of different concentrations (40, 60, 80 and 100% v/v). Former studies have indicated that increasing slow conversion rates induce growing instability. In the current rates, measured as...
The reutilization of wastewater is a key issue with regard to long-term space missions and planetary habitation. This study reports the design, test runs microbiological analyses fixed bed biofiltration system which applies pumice grain (16-25 mm size, 90 m(2)/m(3) active surface) as matrix calcium carbonate buffer. For activation, was inoculated garden soil known contain diverse community microorganisms, thus enabling filtration potentially degrade all kinds organic matter. Current...
The gravity-dependent behavior of Paramecium biaurelia and Euglena gracilis have previously been studied on ground in real microgravity. To validate whether high magnetic field exposure indeed provides a ground-based facility to mimic functional weightlessness, as has suggested earlier, both cell types were observed during strong homogeneous (up 30 T) gradient. While swimming, cells aligned along the lines; orientation was perpendicular, demonstrating that determines thus prevents organisms...