A5030040528- Spaceflight effects on biology
- Anesthesia and Neurotoxicity Research
- Genetics, Aging, and Longevity in Model Organisms
- Circadian rhythm and melatonin
- RNA modifications and cancer
- Lipid Membrane Structure and Behavior
- Cardiac Structural Anomalies and Repair
- Neurogenesis and neuroplasticity mechanisms
- HVDC Systems and Fault Protection
- Neuroscience and Neuropharmacology Research
- Cellular Mechanics and Interactions
Deutsches Zentrum für Luft- und Raumfahrt e. V. (DLR)
2020-2024
University Hospital Heidelberg
2019
Heidelberg University
2019
German Centre for Cardiovascular Research
2019
Conceptually similar to modifications of DNA, mRNAs undergo chemical modifications, which can affect their activity, localization, and stability. The most prevalent internal modification in mRNA is the methylation adenosine at N6-position (m6A). This returns a role as central hub information within cell, serving an carrier, modifier, attenuator for many biological processes. Still, precise such m6A human murine-dilated cardiac tissue remains unknown. Transcriptome-wide mapping allowed us...
Neuronal activity is the key modulator of nearly every aspect behavior, affecting cognition, learning, and memory as well motion. Hence, disturbances transmission synaptic signals are main cause many neurological disorders. Lesions to nervous tissues associated with phenotypic changes mediated by astrocytes becoming reactive. Reactive form basis astrogliosis glial scar formation. Astrocyte reactivity often targeted inhibit axon dystrophy thus promote neuronal regeneration. Here, we aim...
During spaceflight, humans experience a variety of physiological changes due to deviations from familiar earth conditions. Specifically, the lack gravity is responsible for many effects observed in returning astronauts. These impairments can include structural as well functional brain and decline cognitive performance. However, underlying mechanisms remain elusive. Alterations neuronal activity play central role mental disorders altered transmission may also lead diminished human performance...
Abstract Electrophysiological experiments have shown that neuronal activity changes upon exposure to altered gravity. More specifically, the firing rate increases during microgravity and decreases centrifugal-induced hypergravity. However, mechanism by which gravity impacts is still unknown. Different explanations been proposed: a first hypothesis states fluidity of cell membrane modifies properties neurons’ ion channels. Another suggests role mechano-gated (MG) channels depolarizing cells...
Glial scar formation through astrocytes impairs neural regeneration following spinal cord injury, head trauma, or stroke. Astrocyte migration towards the lesion and induction of a reactive astroglial phenotype require dynamic cytoskeletal protein rearrangements. In this glial cell model, hypergravity was used to alter dynamics, i.e. stabilizing microtubules while destabilizing actin filaments. We hypothesize that increased gravitational (mechanical) loading by means centrifugation...
Loss of synaptic plasticity in the brain has been linked to aging-associated cognitive decline and neurodegeneration, thus providing a promising target for therapeutic interventions. Ketamine, drug applied analgesia emergency medicine treatment-resistant depression, some its metabolites rapidly induce plasticity. However, ketamine cannot be reasonably as neuroprotective agent given side-effect profile. With aim dissociate pro-neuroplastic actions from NMDA receptor-mediated psychotropic side...