A5037601946- Spaceflight effects on biology
- Circadian rhythm and melatonin
- Neurogenesis and neuroplasticity mechanisms
- Anesthesia and Neurotoxicity Research
- Genetics, Aging, and Longevity in Model Organisms
University of Bonn
2024
Deutsches Zentrum für Luft- und Raumfahrt e. V. (DLR)
2022-2024
Neuronal activity is the key modulator of nearly every aspect behavior, affecting cognition, learning, and memory as well motion. Hence, disturbances transmission synaptic signals are main cause many neurological disorders. Lesions to nervous tissues associated with phenotypic changes mediated by astrocytes becoming reactive. Reactive form basis astrogliosis glial scar formation. Astrocyte reactivity often targeted inhibit axon dystrophy thus promote neuronal regeneration. Here, we aim...
Abstract Electrophysiological experiments have shown that neuronal activity changes upon exposure to altered gravity. More specifically, the firing rate increases during microgravity and decreases centrifugal-induced hypergravity. However, mechanism by which gravity impacts is still unknown. Different explanations been proposed: a first hypothesis states fluidity of cell membrane modifies properties neurons’ ion channels. Another suggests role mechano-gated (MG) channels depolarizing cells...