A5101969448- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Osteoarthritis Treatment and Mechanisms
- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Bladder and Urothelial Cancer Treatments
- Wnt/β-catenin signaling in development and cancer
- Advanced Chemical Sensor Technologies
- Gas Sensing Nanomaterials and Sensors
- RNA Interference and Gene Delivery
- Neurogenesis and neuroplasticity mechanisms
- Cancer-related molecular mechanisms research
- Knee injuries and reconstruction techniques
- Hair Growth and Disorders
- Cancer Immunotherapy and Biomarkers
- MicroRNA in disease regulation
- Mesenchymal stem cell research
- Tendon Structure and Treatment
- Ovarian cancer diagnosis and treatment
- Tissue Engineering and Regenerative Medicine
- Sirtuins and Resveratrol in Medicine
- Lung Cancer Research Studies
- PARP inhibition in cancer therapy
- Peptidase Inhibition and Analysis
- Radiomics and Machine Learning in Medical Imaging
Tongji University
2015-2025
Peking University
2021-2024
Peking University Third Hospital
2021-2024
Beijing Sport University
2024
Tianjin Medical University Cancer Institute and Hospital
2018-2024
Kunming Medical University
2020-2024
Yan'an Hospital Affiliated To Kunming Medical University
2020-2024
Guangdong Medical College
2024
Harbin Medical University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2023
Osteoarthritis (OA) is a chronic joint disease characterized by progressive degeneration of articular cartilage. A challenge in the development disease-modifying drugs effective delivery to chondrocytes. The unique structure promotes rapid clearance through synovial fluid, and dense avascular cartilage extracellular matrix (ECM) limits drug penetration. Here, we show that poly(lactide- co -glycolic acid) nanoparticles coated chondrocyte membranes (CM-NPs) were preferentially taken up rat...
The intermediate filament protein, nestin, marks progenitor cells of the CNS. Such CNS stem are selectively labeled by placing GFP under control nestin regulatory sequences. During early anagen or growth phase hair follicle, nestin-expressing cells, marked fluorescence in nestin-GFP transgenic mice, appear permanent upper follicle immediately below sebaceous glands bulge. This is where for outer-root sheath thought to be located. relatively small, oval-shaped, bulge area surround shaft and...
LyP-1 is a peptide selected from phage-displayed library that specifically binds to tumor and endothelial cells of lymphatics in certain tumors. Fluorescein-conjugated related peptide, LyP-1b, strongly accumulated primary MDA-MB-435 breast cancer xenografts their metastases i.v. injections, allowing visualization orthotopic tumors intact mice. The LyP accumulation coincided with hypoxic areas induced cell death cultured human carcinoma bind internalize the peptide. Melanoma do not were...
Besides forming hair shafts, the highly organized, metabolically vigorous follicle plays several crucial roles in skin architecture. The contains a distinct population of presumptive follicular stem cells that express nestin, also marker for neural cells. These nestin-expressing are located principally bulge region. Nestin-driven GFP (ND-GFP), transfected into mice, labels region, which is consistent with cells' being follicle. We report here ND-GFP developing blood vessels appear to...
Different stimulus including pH, light and temperature have been used for controlled drug release to prevent inactivation minimize side-effects.Herein a novel nano-platform (GNS@CaCO3/ICG) consisting of calcium carbonate-encapsulated gold nanostars loaded with ICG was established couple the photothermal properties (GNSs) photodynamic indocyanine green (ICG) in photodynamic/photothermal combination therapy (PDT/PTT).In this study, carbonate worked not only keeper entrap on surface GNSs form...
Abstract Colonoscopy is commonly used to screen for colorectal cancer (CRC). We develop a deep learning model called CRCNet optical diagnosis of CRC by training on 464,105 images from 12,179 patients and test its performance 2263 three independent datasets. At the patient-level, achieves an area under precision-recall curve (AUPRC) 0.882 (95% CI: 0.828–0.931), 0.874 (0.820–0.926) 0.867 (0.795–0.923). exceeds average endoscopists recall rate across two sets (91.3% versus 83.8%; two-sided...
The effectiveness of existing tissue-engineering cartilage (TEC) is known to be hampered by weak integration biocompatibility, biodegradation, mechanical strength, and microenvironment supplies. strategy hydrogel-based TEC holds considerable promise in circumventing these problems. Herein, a non-toxic, biodegradable, mechanically optimized double-network (DN) hydrogel consisting polyethylene glycol (PEG) kartogenin (KGN)-conjugated chitosan (CHI) constructed using simple soaking strategy....
Osteochondral injury is a common and frequent orthopedic disease that can lead to more serious degenerative joint disease. Tissue engineering promising modality for osteochondral repair, but the implanted scaffolds are often immunogenic induce unwanted foreign body reaction (FBR). Here, we prepare polypept(o)ide-based PAA-RGD hydrogel using novel thiol/thioester dual-functionalized hyperbranched polypeptide P(EG3Glu-co-Cys) maleimide-functionalized polysarcosine under biologically benign...
<h3>Aims</h3> Wnt signalling is involved in cellular homeostasis and development. Dysregulation of the pathway has been linked to colorectal cancer. The orphan nuclear receptor TR3 plays important roles proliferation apoptosis. In this study, we investigated how suppresses intestinal tumorigenesis by regulating signalling. <h3>Methods</h3> Intestinal polyps were quantified <i>Apc<sup>min/+</sup></i>, <i>Apc<sup>min/+</sup>/TR3<sup>−/−</sup></i> <i>Apc<sup>min/+</sup>/villin-TR3</i> mice....
Effective treatment of glioma and other central nervous system (CNS) diseases is hindered by the presence blood-brain barrier (BBB). A novel nano-delivery vehicle composed PLGA-lysoGM1/DOX micelles was developed to cross BBB for CNS treatment. We have shown that doxorubicin (DOX) as a model drug encapsulated in PLGA-lysoGM1 can achieve up 3.8% loading efficiency 61.6% encapsulation orthogonal test design. Our vitro experiments demonstrated had slow sustainable release under physiological...
Decreased serum ferritin level was recently found in schizophrenia. Whether the brain iron concentration schizophrenia exists abnormality is of research significance. Quantitative susceptibility mapping (QSM) used this study to assess changes grey matter nuclei patients with first-episode The local ethics committee approved study, and all subjects gave written informed consent. Thirty 30 age gender-matched healthy controls were included study. QSM effective transverse relaxation rate (R2*)...
Abstract We have recently shown that the neural-stem cell marker nestin is expressed in hair follicle stem cells and blood vessel network interconnecting follicles skin of transgenic mice with regulatory element–driven green fluorescent protein (ND-GFP). The were to give rise nestin-expressing vessels skin. In present study, we visualized tumor angiogenesis by dual-color fluorescence imaging ND-GFP after transplantation murine melanoma line B16F10 expressing red protein. was highly...
We developed a novel transparent conductive film, molybdenum-doped indium oxide (IMO). Using normal thermal reactive evaporation without any special treatments, IMO films have been prepared on glass microscope slides at about 350 °C with electrical resistivity of 1.7×10−4 Ω cm, mobility over 100 cm2 V−1 s−1, and an average spectral transmittance in the visible region 80%. From x-ray photoelectron spectroscopy diffraction spectra films, it is confirmed that lattice same as In2O3 cubic...
Targeted imaging and tumor therapy using nanomaterials has stimulated research interest recently, but the high cytotoxicity low cellular uptake of limit their bioapplication. In this paper, glucose (Glc) was chosen to functionalize Au nanoprisms (NPrs) for improving Au@PEG-Glc NPrs into cancer cells. Glucose is a primary source energy at level membranes cell recognition. A coating facilitates accumulation in region much more than Au@PEG NPrs. Due excellent photoabsorbing property NPrs,...