A5006342956- Advanced MRI Techniques and Applications
- Medical Imaging Techniques and Applications
- MRI in cancer diagnosis
- Advanced Neuroimaging Techniques and Applications
- Medical Image Segmentation Techniques
- Photoacoustic and Ultrasonic Imaging
- Hemoglobinopathies and Related Disorders
- Advanced X-ray and CT Imaging
- Advanced X-ray Imaging Techniques
- Cardiac Imaging and Diagnostics
- Ultrasound Imaging and Elastography
- Atomic and Subatomic Physics Research
- Functional Brain Connectivity Studies
- Ultrasound and Hyperthermia Applications
- Neural dynamics and brain function
- Sparse and Compressive Sensing Techniques
- Iron Metabolism and Disorders
- Radiomics and Machine Learning in Medical Imaging
- Lanthanide and Transition Metal Complexes
- Cardiovascular Function and Risk Factors
- Liver Disease Diagnosis and Treatment
- Nanoplatforms for cancer theranostics
- Electromagnetic wave absorption materials
- Thermography and Photoacoustic Techniques
- Bone and Joint Diseases
Southern Medical University
2015-2024
Institute of New Materials
2024
Shandong University
2023-2024
The First People's Hospital of Shunde
2022-2024
State Key Laboratory of Crystal Materials
2024
Zhujiang Hospital
2023
Nanjing Normal University
2020
Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques
2020
Sorbonne Paris Cité
2020
Université Paris Cité
2020
Content-based image retrieval (CBIR) techniques have currently gained increasing popularity in the medical field because they can use numerous and valuable archived images to support clinical decisions. In this paper, we concentrate on developing a CBIR system for retrieving brain tumors T1-weighted contrast-enhanced MRI images. Specifically, when user roughly outlines tumor region of query image, database same pathological type are expected be returned. We propose novel feature extraction...
Ferroptosis therapy (FT) efficacy of tumors suffers from a relatively low concentration Fenton agents, limited hydrogen peroxide (H2O2) content, and insufficient acidity in the tumor environment (TME), which are unfavorable for reactive oxygen species (ROS) generation based on or Fenton-like reactions. The glutathione (GSH) overexpression TME can scavenge ROS abate FT performance. In this study, strategy storm specifically initiated by our developed nanoplatforms (TAF-HMON-CuP@PPDG) is...
Major depressive disorder (MDD) is a globally prevalent and highly disabling disease characterized by dysfunction of large-scale brain networks. Previous studies have found that static functional connectivity not sufficient to reflect the complicated time-varying properties brain. The underlying dynamic interactions between networks MDD remain largely unknown, it also unclear whether neuroimaging-based are sufficiently robust discriminate individuals with from healthy controls since...
Purpose: To compare myocardial T1 against T2 and T2* in patients with thalassemia major (TM) for iron characterization. Materials Methods: A total of 106 TM (29 ± 10 years; 58 males) were studied on a 1.5 Tesla scanner using dedicated T1, T2*, relaxometry sequences. single mid‐ventricular short axis slice was acquired within breath‐hold. Results: In overload (T2* < 20 ms; n = 52), there linear correlations between (r 0.82; P 0.0), 0.83; 0.0). no (n 54), values scattered significant...
Major depressive disorder (MDD) is a devastating mental that affects up to 17% of the population worldwide. Although brain-wide network-level abnormalities in MDD patients via resting-state functional magnetic resonance imaging (rsfMRI) exist, mechanisms underlying these network changes are unknown, despite their immense potential for depression diagnosis and management. Here, we show astrocytic calcium-deficient mice, inositol 1,4,5-trisphosphate-type-2 receptor knockout mice ( Itpr2 −/−...
Abstract Sleep is ubiquitous and essential, but its mechanisms remain unclear. Studies in animals humans have provided insights of sleep at vastly different spatiotemporal scales. However, challenges to integrate local global information sleep. Therefore, we developed fMRI based on simultaneous electrophysiology 9.4 T male mice. Optimized un-anesthetized mouse setup allowed manifestation NREM REM sleep, a large dataset was collected openly accessible. State dependent patterns were revealed,...
Accurate and reproducible MRI R 2 * relaxometry for tissue iron quantification is important in managing transfusion‐dependent patients. data are often acquired using array coils reconstructed by the root‐sum‐square algorithm, as such, measured signals follow noncentral chi distribution. In this study, two noise‐corrected models were proposed liver quantification: fitting signal to first moment squared second presence of noise. These compared with widely implemented offset truncation on both...
Decreased serum ferritin level was recently found in schizophrenia. Whether the brain iron concentration schizophrenia exists abnormality is of research significance. Quantitative susceptibility mapping (QSM) used this study to assess changes grey matter nuclei patients with first-episode The local ethics committee approved study, and all subjects gave written informed consent. Thirty 30 age gender-matched healthy controls were included study. QSM effective transverse relaxation rate (R2*)...
Purpose This work aims to develop a novel distortion‐free 3D‐EPI acquisition and image reconstruction technique for fast robust, high‐resolution, whole‐brain imaging as well quantitative mapping. Methods 3D Blip‐up ‐down (3D‐BUDA) sequence is designed both single‐ multi‐echo gradient recalled echo (GRE)‐EPI using multiple shots with blip‐up readouts encode B 0 field map information. Complementary k‐space coverage achieved controlled aliasing in parallel (CAIPI) sampling across the shots. For...
Based on MnO2/carbon cloth (CC) composite materials, an Ag-doped MnO2 nanowire, self-assembled, urchin-like structure was synthesized in situ the surface of CC using a simple method, and novel efficient flexible electrode material for supercapacitors developed. The morphology, structure, elemental distribution, pore distribution were analyzed SEM, TEM, XRD, XPS, BET. electrochemical performance tested cyclic voltammetry (CV) galvanostatic charge/discharge (GCD). In three-electrode system,...
This study investigated the effect of different monomer compositions acrylonitrile (AN) and methyl methacrylate (MMA) on synthesis expansion performance thermally expandable microspheres (TEMs). TEMs with ratios, specifically AN to MMA ratios 100:0, 90:10, 80:20, 70:30, were synthesized via free radical suspension polymerization. The inner morphology, crystallinity, blowing agent encapsulation efficiency, ratio analyzed using scanning electron microscopy (SEM), Fourier-transform infrared...
Background: Myocardial black blood (BB) T2* relaxometry at 1.5T provides robust, reproducible and calibrated non-invasive assessment of cardiac iron burden.In vitro data has shown that like T2*, novel native Modified Look-Locker Inversion recovery (MOLLI) T1 shortens with increasing tissue iron.The relative merits are largely unexplored.We compared the established BB technique against values 3T in overload patients normal volunteers.Methods: A total 73 subjects (42 male) were recruited,...
Denoising is critical for improving visual quality and reliability of associative quantitative analysis when magnetic resonance (MR) images are acquired with low signal-to-noise ratios. The classical non-local means (NLM) filter, which averages pixels weighted by the similarity their neighborhoods, adapted demonstrated to effectively reduce Rician noise without affecting edge details in MR magnitude images. However, NLM (RNLM) filter usually blurs small high-contrast particle might be...
Chronic kidney disease (CKD) has a high prevalence worldwide. Renal fibrosis is the common pathological feature in various types of CKD. However, underlying mechanisms are not determined. Here, we adopted different CKD mouse models and cultured human proximal tubular cell line (HKC-8) to examine expression C-X-C motif chemokine receptor 4 (CXCR4) β-catenin signalling, as well their relationship renal fibrosis. In mice humans with variety nephropathies, CXCR4 was dramatically up-regulated...
As an emerging molecular imaging modality, Photoacoustic Tomography (PAT) is capable of mapping tissue physiological metabolism and exogenous contrast agent information with high specificity. Due to its ultrasonic detection mechanism, the precise localization targeted lesions has long been a challenge for PAT imaging. The poor soft-tissue image makes this process difficult inaccurate. To meet challenge, in study, we first make use rich clear structural brought about by another advanced...
Purpose To develop a machine learning approach using convolutional neural network for reducing MRI Gibbs‐ringing artifact. Theory and Methods artifact in MR images is caused by insufficient sampling of the high frequency data. Existing methods exploit smooth constraints to reduce intensity oscillations near sharp edges at cost blurring details. In this work, we developed removing from images. The ringing was extracted original image deep then subtracted obtain artifact‐free image. Finally,...
Abstract The discovery of functional gradients introduce a new perspective in understanding the cortical spectrum intrinsic dynamics, as it captures major axes connectivity low-dimensional space. However, how arise and dynamically vary remains poorly understood. In this study, we investigated biological basis using awake resting-state fMRI, retrograde tracing gene expression datasets marmosets. We found marmosets showed sensorimotor-to-visual principal gradient followed by...
Purpose The existing approach of Nyquist ghost correction by parallel imaging in echo planar (EPI) can suffer from image noise amplification. We propose a method that estimates phase error map multi‐channel data itself and incorporates it into the sensitivity encoding (SENSE) reconstruction for without compromising SNR. Methods This first reconstructs two ghost‐free images positive negative echoes using SENSE, respectively, which is computed. then incorporated coil maps during joint SENSE...
Optoacoustic tomography (OAT) is an emerging imaging modality with ultrasonic depth and optical contrast. The reconstruction of optoacoustic image to recover the initial acoustic pressure distribution object from a set ultrasound signals. model-based ill-conditioned inverse problem affected by factors such as limited detection angle, imperfect model, noise. Accounting for this, appropriate penalties should be incorporated into process improve quality. In this paper, we present new...
Background : Brain iron deposition, low hemoglobin (HGB), and increased heme oxygenase-1 (HO-1) have been implicated in Parkinson’s disease (PD). However, the association among them PD is poorly studied. Objective To explore of level HO-1 with brain deposition HGB PD. Methods A total 32 patients 26 controls were recruited for this study. C57BL/6 male mice used generating 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced chronic model. The Levels serum human subjects assayed by...