A5102748874- Nerve injury and regeneration
- Neuroinflammation and Neurodegeneration Mechanisms
- Spinal Cord Injury Research
- Adenosine and Purinergic Signaling
- Spine and Intervertebral Disc Pathology
- Cervical and Thoracic Myelopathy
- Parkinson's Disease Mechanisms and Treatments
- Medical Research and Treatments
- Advanced Radiotherapy Techniques
- Breast Cancer Treatment Studies
- Neurogenesis and neuroplasticity mechanisms
- Spinal Fractures and Fixation Techniques
- Electrospun Nanofibers in Biomedical Applications
- Inflammasome and immune disorders
- Spinal Hematomas and Complications
- Circular RNAs in diseases
- Educational Reforms and Innovations
- Intensive Care Unit Cognitive Disorders
- Tissue Engineering and Regenerative Medicine
- MicroRNA in disease regulation
- Radiation Dose and Imaging
- Neurological Disease Mechanisms and Treatments
- Radiation Therapy and Dosimetry
- Cerebrospinal fluid and hydrocephalus
- Hereditary Neurological Disorders
Sun Yat-sen University
2016-2025
Third Affiliated Hospital of Sun Yat-sen University
2020-2025
The First Affiliated Hospital, Sun Yat-sen University
2015-2024
Nantong University
2021-2024
Southern Medical University
2018-2022
Nanfang Hospital
2018-2022
Sichuan Cancer Hospital
2014-2020
First People's Hospital of Yunnan Province
2020
University of Electronic Science and Technology of China
2019
Deyang Stomatological Hospital
2017
Neuroinflammation is a major driver of age-related brain degeneration and concomitant functional impairment. In patients with Alzheimer's disease, the most common form dementia, factors that enhance neuroinflammation may exacerbate disease progression, in part by impairing glymphatic system responsible for clearance pathogenic beta-amyloid. Inflammatory bowel diseases (IBDs) induce cognitive impairment elderly. The NACHT-LRR pyrin (PYD) domain-containing protein 3 (NLRP3) inflammasome has...
A favorable microenvironment plays an important role in nerve regeneration. Extracellular matrix (ECM) derived from cultured cells or natural tissues can facilitate regeneration the presence of various microenvironmental cues, including biochemical, spatial, and biomechanical factors. This study, through proteomics three-dimensional image analysis, determines that components spatial organization ECM secreted by bone marrow mesenchymal (BMSCs) are more similar to acellular nerves than those...
The repair of white matter injury is significant importance for functional recovery after ischemic stroke, and the up-regulation triggering receptors expressed on myeloid cells 2 (TREM2) stroke neuroprotective implicated in remyelination. However, lack effective therapies calls need to investigate regenerative process remyelination role rehabilitation therapy. This study sought whether how moderate physical exercise (PE) promotes oligodendrogenesis rats with transient middle cerebral artery...
Abstract Alzheimer’s disease (AD), the most common form of dementia, is marked by progressive cognitive decline, deposition misfolded amyloid-β (Aβ) peptide and formation neurofibrillary tangles. Recently, microglial training has emerged as an important contributor to neurological diseases, which augments subsequent inflammation. However, how it affects pathology AD remains unknown. Here, using a mouse model sporadic (SAD) induced streptozotocin injection, we demonstrated that exacerbated Aβ...
The clinical therapeutics for nerve tissue regeneration and functional recovery after spinal cord injury (SCI) are very limited because of the complex biological processes inhibitory microenvironment. Advanced biomaterials highly desired to avoid severe secondary damage provide guidance axonal regrowth. Multichannel nanofibrous scaffolds were modified with gelatin cross-linked by genipin. gelatin-coated nanofibers exhibited strong binding affinity neurotrophin-3, which underwent a...
Neurological functional recovery depends on the synergistic interaction between angiogenesis and neurogenesis after peripheral nerve injury (PNI). Decellularized matrix hydrogels have drawn much attention been considered as potential therapeutic biomaterials for neurovascularization, due to their intrinsic advantages in construction of a growth-permissive microenvironment, strong affinity multiple growth factors (GFs), promotion neurite outgrowth. In present study, factor (NGF) vascular...
Microglia are more susceptible to ferroptosis compared neurons and astrocytes, which may compromise their phagocytic clearance capabilities of α-synuclein (α-syn) in Parkinson's disease (PD). While the beneficial effects physical exercise (PE) on reducing α-syn deposition PD have been highlighted, role PE modulating microglial remains unclear. This study focuses impact inhibiting mitigating accumulation. We demonstrate that voluntary effectively inhibits ferroptosis. Mechanistically,...
Mitochondrial creatine kinase (MtCK) is vital in the process of mitochondrial energy metabolism, and dysfunction has been implicated pathogenesis Parkinson's disease (PD). Therefore, we speculated that MtCK activity could be altered serum PD patients. However, no studies to date have investigated this specific topic, so sought investigate activities among a cohort 50 patients with 30 age-matched controls were recruited for study. Serum ubiquitous (uMtCK) sarcomeric (sMtCK) assayed using an...
Endogenous repair after chronic compressive spinal cord injury (CCSCI) is of great clinical interest. Ischemia−hypoxia-induced angiogenesis has been proposed to play an important role during this process. Emerging evidence indicates that long non-coding RNAs (lncRNAs) are involved in the pathophysiological processes various diseases. Here, we identified a lncRNA (Xist; X-inactive specific transcript) with upregulated expression cervical spine lesions endogenous neurological CCSCI rats....
Neurological degeneration can occur after compression of the spinal cord. It is widely accepted that cord leads to ischemic lesions and ultimately neurological dysfunction due a narrowed canal. Therefore, an in-depth understanding pathogenesis injury required help develop effective clinical interventions. In present study, we propose new method quantitative 3D micro-CT observe microvascular events in chronic rat model. A total 36 rats were divided into two groups: sham control group (n = 12)...
ADA16 peptide hydrogels have been broadly used in tissue engineering due to their good biocompatibility and nanofibrous structure mimicking the native extracellular matrix (ECM). However, low mechanical strength often fails them as implantable scaffolds. To improve stability of RADA16 hydrogel, a photocrosslinkable diacrylated poly(ϵ-caprolactone)-b-poly(ethylene glycol)-b-poly(ϵ-caprolactone) triblock copolymer (PCECDA) was physically combined with pre-modified cell adhesive Arg-Gly-Asp...
Background : Brain iron deposition, low hemoglobin (HGB), and increased heme oxygenase-1 (HO-1) have been implicated in Parkinson’s disease (PD). However, the association among them PD is poorly studied. Objective To explore of level HO-1 with brain deposition HGB PD. Methods A total 32 patients 26 controls were recruited for this study. C57BL/6 male mice used generating 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced chronic model. The Levels serum human subjects assayed by...
Abstract Objective This study aimed at determining the characteristics of systemic inflammation and brain iron deposition in Parkinson's disease (PD) patients. Methods Thirty two PD patients 30 gender‐ as well age‐matched controls were enrolled. Serum interleukin (IL)‐1β, IL‐33, tumor necrosis factor (TNF)‐α, IL‐6, IL‐10, ferritin, iron, total binding capacity (TIBC) levels assayed. Quantitative susceptibility mapping (QSM) was used to quantitatively analyze accumulation regions interest...
Studies have shown the spatial specificity of cranial iron deposition in different regions Parkinson's disease (PD). However, time-specific patterns are not yet clear. The purpose this study was to investigate time pattern variations and its clinical relevance multiple gray matter nuclei PD using quantitative susceptibility mapping (QSM). Thirty controls 33 patients were enrolled, namely, 11 cases early stage (ESP) 22 advanced (ASP) according Hoehn-Yahr stages. content subcortical covering...
Chronic spinal cord compression is the most common cause of impairment worldwide. Objective this study to assess ultrastructural features neurovascular unit (NVU) in a rat model chronic compressive injury, 24 SD rats were divided into two groups: control group (n = 12), and 12). A C6 semi-laminectomy was performed group, whereas water-absorbent polyurethane polymer implanted epidural space group. The Basso Beattie Bresnahan (BBB) scores somatosensory evoked potentials (SEP) used evaluate...
Abstract Aims Physical exercise (PE) can accelerate post‐stroke recovery. This study investigated contributions of circRNAs to PE‐induced improvements in neurological function. Methods Rats subjected transient middle cerebral artery occlusion were left sedentary or provided running‐wheel access for 4 weeks during CircRNAs from peri‐infarct cortex identified by high‐throughput sequencing, and interactions with miRNAs immunoprecipitation, fluorescence suit hybridization, dual‐luciferase...
This was a retrospective comparative study.The main objective of this study to investigate the effects epidural anesthesia (EA) versus general (GA) in elderly patients undergoing lower lumbar spine fusion surgeries.Lumbar surgery can be performed under GA or regional anesthesia. is more commonly used surgery, which renders patient motionless throughout procedure and provides secure airway. Although EA associated with superior hemodynamic status, reduced duration operation, less health care...
The purpose of this study was to evaluate the feasibility delineating substructure heart by using 64‐slice spiral CT coronary angiography (CTA) in breast cancer patients who underwent left breast‐conserving surgery, and compare dosimetric differences between targets organs at risk prone supine positions intensity‐modulated radiation therapy (IMRT) planning. From January December 2011, ten surgery were enrolled study. CTA performed both during simulation, conventional scanning without same...
The cervicothoracic junction (CTJ) site accounts for approximately 10% of all spinal metastases. complex anatomical and biomechanical features increase the difficulty in surgical treatment CTJ However, few studies literature on metastases are focusing this special area. aim study was to evaluate outcome patients with analyze prognostic factor postoperative survival. Total 34 who underwent surgery our department were retrospectively analyzed. We evaluated records details medical history,...