A5100387636- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Helicobacter pylori-related gastroenterology studies
- Spondyloarthritis Studies and Treatments
- Bone and Dental Protein Studies
- Scoliosis diagnosis and treatment
- Rheumatoid Arthritis Research and Therapies
- Musculoskeletal pain and rehabilitation
- Bone Metabolism and Diseases
- Pregnancy-related medical research
- Cervical and Thoracic Myelopathy
- Musculoskeletal synovial abnormalities and treatments
- Probiotics and Fermented Foods
- IgG4-Related and Inflammatory Diseases
- Intraperitoneal and Appendiceal Malignancies
- Systemic Lupus Erythematosus Research
- Connective tissue disorders research
- Folate and B Vitamins Research
- Erythrocyte Function and Pathophysiology
- dental development and anomalies
- Medicinal Plants and Bioactive Compounds
- Pelvic and Acetabular Injuries
- Osteoarthritis Treatment and Mechanisms
- Reproductive System and Pregnancy
- Soft tissue tumor case studies
Sun Yat-sen University
2016-2025
The First Affiliated Hospital, Sun Yat-sen University
2016-2025
Key Laboratory of Guangdong Province
2020-2025
Affiliated Eye Hospital of Wenzhou Medical College
2025
Wenzhou Medical University
2025
Zhejiang Lab
2025
Wuhan Children's Hospital
2024
Huazhong University of Science and Technology
2024
Zunyi Medical University
2024
Nanchang University
2022-2024
Abstract The inflammatory response is induced by the overexpression of cytokines, mainly interleukin (IL)-1β, and one main causes intervertebral disc degeneration (IVDD). NLR pyrin domain containing 3 (NLRP3) inflammasome activation an important source IL-1β. As anti-inflammatory neuroendocrine hormone, melatonin plays various roles in different pathophysiological conditions. However, its IVDD are still not well understood require more examination. First, we demonstrated that delayed...
Percutaneous vertebroplasty (PVP) and percutaneous balloon kyphoplasty (PKP) can increase bone strength as well alleviate the pain caused by vertebral compression fractures (VCFs), both procedures rely on polymethyl methacrylate (PMMA) cement injected into fractured vertebra for mechanical stabilization of VCFs. However, there is debate over which these 2 surgical give better short-term long-term outcomes. A lot studies meta-analysis were designed to assess advantages drawbacks PKP PVP in...
Inadequate tendon healing and heterotopic bone formation result in substantial pain disability, yet the specific cells responsible for remain uncertain. Here we identify a CD26+ stem/progenitor residing peritendon, which constitutes primitive stem cell population with self-renewal multipotent differentiation potentials. migrate into midsubstance tenocytes during healing, while ablation of these led to insufficient healing. Additionally, contribute ossification Tenascin-C-Hippo signaling is...
Adherence of Helicobacter pylori to inflamed gastric mucosa is dependent on the sialic acid-binding adhesin (SabA) and cognate sialylated/fucosylated glycans host cell surface. By in situ hybridization, H. bacteria were observed close association with erythrocytes capillaries post-capillary venules lamina propria both infected humans Rhesus monkeys. In vivo adherence may require molecular mechanisms similar acid-dependent vitro agglutination (i.e., hemagglutination). this context, SabA was...
Abstract Aim The aim of this study was to investigate whether two Lactobacillus reuteri strains (rat‐derived R2 LC and human‐derived ATCC PTA 4659 (4659)) could protect mice against colitis, as well delineate the mechanisms behind protection. Methods Mice were given L. or by gavage once daily for 14 days, colitis induced addition 3% DSS (dextran sulphate sodium) drinking water last 7 days period. severity disease assessed through clinical observations, histological evaluation ELISA...
To investigate the molecular mechanism underlying inflammation-related ectopic new bone formation in ankylosing spondylitis (AS).Spinal tissues and sera were collected from patients with AS healthy volunteers examined for expression of Wnt proteins. An vitro cell culture system mimicking local inflammatory microenvironment bone-forming sites was established to study relationship between inflammation expression, regulatory inflammation-induced role signaling formation. Modified...
To investigate the clinical features, outcome, and risk factors of disease flares in patients with pregnancy-related lupus (PRL).Medical charts 155 consecutive PRL inpatients were systematically reviewed, including demographic data, laboratory findings, treatment, complications, outcome.PRL cases divided into active (a-PRL) (n = 82, 53.0%) stable (s-PRL) 73, 47.0%). Compared nonpregnant female systemic erythematosus (SLE) patients, a-PRL new-onset (n-PRL) flare (f-PRL) 41 respectively), had...
The aim of this study was to identify the role tenascin-C (TNC) in entheseal new bone formation and explore underlying molecular mechanism.Ligament tissue samples were obtained from patients with ankylosing spondylitis (AS) during surgery. Collagen antibody-induced arthritis DBA/1 models established observe formation. TNC expression determined by immunohistochemistry staining. Systemic inhibition or genetic ablation performed animal models. Mechanical properties extracellular matrix (ECM)...
Abstract Background Intervertebral disc degeneration (IVDD)-related disorders are the major causes of low back pain. A previous study suggested that Notch activation serves as a protective mechanism and is part compensatory response maintains necessary resident nucleus pulposus (NP) cell proliferation to replace lost or non-functional cells. However, exact remains be determined. In this study, we aimed investigate role JAG2/Notch2 in NP apoptosis. Methods Recombinant JAG2 Notch2, Hes1, Hey2...
Ankylosing spondylitis (AS) is a chronic inflammatory disease characterized by back pain and spinal ankylosis due to pathological new bone formation. Here, we identified CXCL12 as critical contributor formation through recruitment of osteogenic precursor cells (OPCs). was found highly expressed in the regions that would potentially develop bone. OPCs were recruited where up-regulated. Inhibition CXCL12/CXCR4 axis with AMD3100 or conditional knockout CXCR4 attenuated migration subsequent...
CPAMD8, a constituent of the A2M/C3 (α-2-macroglobulin/complement 3) protein family, is strikingly expressed in human fetal lens and distal neural retina. Mutations CPAMD8 have been linked to anterior segment dysgenesis primary congenital glaucoma. We utilized CRISPR/Cas9 technology establish homozygous knockout embryonic stem cell line for differentiating retinal organoids, with intent exploring role early development eye. The exhibits normal morphology, pluripotency, karyotype, serving as...
Abstract Pathological new bone formation is the main cause of disability in ankylosing spondylitis (AS), and so far, it lacks a targeted therapy. Macrophages are central orchestrators inflammation progression tissue remodeling, but their contribution to pathological has largely not been explored. Here, identified that TREM2 + macrophages predominated within sites adjacent osteogenic precursor cells. In vivo, both depletion knockout Trem2 significantly reduced collagen antibody‐induced...
Abstract Salidriside (SDS), a phenylpropanoid glycoside derived from Rhodiola rosea L , has been shown to be neuroprotective in many studies, which may promising nerve recovery. In this study, the effects of SDS on engineered constructed by Schwann cells (SCs) and Poly (lactic-co-glycolic acid) (PLGA) were studied vitro . We further investigated effect combinational therapy PLGA/SCs based tissue engineering peripheral regeneration rat model injury sciatic transection. The results showed that...
The tooth enamel organ (EO) is a complex epithelial cell assembly involved in multiple aspects of development, including amelogenesis. present study focuses on the role nonameloblast layers EO, stratum intermedium, stellate reticulum, and outer epithelium (OEE). secretory stage intermedium was distinguished by p63-positive stem marks, highly specific alkaline phosphatase labeling, as well desmosomes gap junctions. At location presecretory pre-eruption EO prominently featured papillary layer...
Study Design A prospective cross-sectional study. Purpose To evaluate the risk factors associated with severity of pain intensity in patients non-specific low back (NSLBP) Southern China. Overview Literature Low (LBP) is leading cause activity limitation and work absence throughout world, so a firm understanding factor NSLBP can provide early prompt interventions that are aimed at attaining long-term results. Methods Participants were recruited from January 2014 to 2016 surveyed using...