A5078301701- Spine and Intervertebral Disc Pathology
- GaN-based semiconductor devices and materials
- Analytical Chemistry and Chromatography
- ZnO doping and properties
- Microfluidic and Capillary Electrophoresis Applications
- Ga2O3 and related materials
- Microfluidic and Bio-sensing Technologies
- Nanowire Synthesis and Applications
- Analytical Methods in Pharmaceuticals
- Pregnancy-related medical research
- Medical and Biological Ozone Research
- Quantum Dots Synthesis And Properties
- thermodynamics and calorimetric analyses
- Musculoskeletal pain and rehabilitation
- Advanced Chemical Sensor Technologies
- Water Treatment and Disinfection
- Molecular Sensors and Ion Detection
- Photocathodes and Microchannel Plates
- Pain Management and Treatment
- Bone Metabolism and Diseases
- Scoliosis diagnosis and treatment
- Endometriosis Research and Treatment
- Fetal and Pediatric Neurological Disorders
- Protein purification and stability
- Chalcogenide Semiconductor Thin Films
Johns Hopkins Medicine
2023-2025
Johns Hopkins University
2023-2025
The First Affiliated Hospital, Sun Yat-sen University
2020-2025
Sun Yat-sen University
2020-2025
Shenzhen University
2025
Merck & Co., Inc., Rahway, NJ, USA (United States)
2014-2024
Guangzhou University
2024
Zhongshan Hospital
2024
Key Laboratory of Guangdong Province
2023
Xiamen University
2010-2019
Well-aligned ZnO/ZnSe core/shell nanowire arrays with type-II energy alignment are synthesized via a two-step chemical vapor deposition method. Morphology and structure studies reveal transition layer of wurtzite ZnSe between the ZnO core cubic shell. Type-II interfacial transitions observed in spectral region from visible to near infrared transmission photoluminescence. More significantly, for first time, is shown extend photoresponse prototype photovoltaic device based on coaxial array...
ABSTRACT Objectives To evaluate the feasibility of using deep‐learning algorithms to classify as normal or abnormal sonographic images fetal brain obtained in standard axial planes. Methods We included study retrieved from a large hospital database 10 251 and 2529 pregnancies. Abnormal cases were confirmed by neonatal ultrasound, follow‐up examination autopsy. After series pretraining data processing steps, 15 372 14 047 planes obtained. These divided into training test datasets (at case...
Abstract The progressive downscaling of silicon‐based microelectronic devices delivers compact and advanced integrated circuits for fast data processing computing. Similarly, the miniaturization conventional optoelectronics is also an important frontier technology emerging lighting, imaging, communication, sensing. Herein, this study reports a miniature dual‐functional diode (DF‐diode) with both light‐emitting light‐detecting functionalities. proposed micro‐scale DF‐diode exhibits record...
To develop and validate an artificial intelligence system, the Prenatal ultrasound diagnosis Artificial Intelligence Conduct System (PAICS), to detect different patterns of fetal intracranial abnormality in standard sonographic reference planes for screening congenital central nervous system (CNS) malformations.Neurosonographic images from normal fetuses with CNS malformations at 18-40 gestational weeks were retrieved databases two tertiary hospitals China assigned randomly (ratio, 8:1:1)...
Most secondary amines have the potential to undergo nitrosation in presence of nitrite under certain conditions, particularly at low pH, generate N-nitrosamines. Tertiary are generally considered be less prone nitrosamine formation as they require an additional dealkylation step. A review published literature combined with recently generated experimental data from experiments carried out on several trialkyl further informs extent that tertiary can form N-nitrosamines by reaction trace levels...
Abstract The recent detection of potent carcinogenic nitrosamine impurities in several human medicines has triggered product recalls and interrupted the supply critical medications for hundreds millions patients, illuminating need increased testing nitrosamines pharmaceutical products. However, development analytical methods is challenging due to high sensitivity requirements, complex matrices, large number variety samples requiring testing. Herein, we report an method analysis a common...
Chronic low back pain (LBP) is a significant global health concern, often linked to vertebral bone marrow lesions (BML), particularly fatty replacement (FR). This study aims explore the relationship between gut microbiome, serum metabolome, and FR in chronic LBP patients. Serum metabolomic profiling microbiome analysis were conducted patients with without (LBP + FR, n = 40; LBP, 40) Healthy Controls (HC, 31). The investigates alterations branched-chain amino acids (BCAAs) levels identifies...
We report the unexpected radial migration of DNA molecules in capillary electrophoresis (CE) with applied Poiseuille flow. Such movement can contribute to anomalous times, peak dispersion, and size shape selectivity CE. When flow is from cathode anode, move toward center capillary, forming a narrow, highly concentrated zone. Conversely, when anode cathode, walls, leaving DNA-depleted zone around axis. showed that deformation orientation under was responsible for migration. By analyzing...
Under specific experimental conditions, the electrokinetic separation of certain microorganisms can produce peaks very high apparent efficiencies (∼106−1010 theoretical plates/m). This is unusual in that no deliberate focusing mechanism was employed. To investigate this process further, monitored real time using a charge-coupled device (CCD) imaging system. At least two different processes seem to be operative when these narrow are observed. The initial field-induced association cells...
Spinal pain affects individuals of all ages and is the most common musculoskeletal problem globally. Its clinical management remains a challenge as underlying mechanisms leading to it are still unclear. Here, we report that significantly increased numbers senescent osteoclasts (SnOCs) observed in mouse models spinal hypersensitivity, like lumbar spine instability (LSI) or aging, compared controls. The larger population SnOCs associated with induced sensory nerve innervation, well growth...
Abstract Multiple myeloma (MM) is a prevalent hematologic malignancy characterized by abnormal proliferation of cloned plasma cells. Given the aggressive nature and drug resistance MM cells, identification novel genes could provide valuable insights for treatment. In this study we performed machine learning in RNA microarray data purified cell samples from five independent cohorts with 957 patients, identified O-GlcNAcylation transferase ( OGT ) division cycle 27 CDC27 as key prognostic MM....
Degeneration of articular cartilage is the key underlying cause most joint-related diseases and yet little known about its regeneration. Here, we report that skeletal interoception induces anabolic synthesis superficial membrane by tuning down sympathetic norepinephrine (NE). Specifically, consumed during animal activity anabolically renewed underneath chondrocytes in zone (SFZ). Notably, stereotactic knockdown NE paraventricular nucleus, thickness increases. Moreover, deletion gene encoding...
We demonstrate a novel separation mechanism for large molecules based on their radial migration in capillary electrophoresis with applied hydrodynamic flow (HDF). The direction of depends the HDF relative to electric field. velocities are size-dependent, which could be attributed different degree deformation under shear flow. Analytical was demonstrated sample plug containing lambda DNA (48 502 bp) and phiX174 RF (5386 baseline separation. Alternatively, this mode can performed continuously...
We studied the aggregation of a rod-shaped bacteria, Bifidobacterium infantis, during capillary electrophoresis (CE). A microscope with an intensified CCD camera was employed to monitor migration and which are labeled fluorescent dye Syto 9 excited 488-nm argon ion laser. collision-based mechanism is proposed, in collisions between microbes result from different mobilities directions electric field. Individual aligned differently respect direction field exhibit drag coefficients. The...
Abstract Background An experimental study was performed to improve the anterior approach model of intervertebral disc degeneration (IVDD). Objective The aims this were investigate IVDD for cause death, phenotypes, and underlying mechanisms low back pain in mice. Method In study, we conducted an puncture procedure on a cohort 300 C57BL/6J mice that 8 weeks old. Our investigation focused exploring causes death population ( n = 300) assessing time‐course changes various parameters, including...
The light extraction from AlGaN deep ultraviolet light-emitting diodes (UV LEDs) is known to be limited by the fundamental valence band crossover issue.