A5032567364- Cancer Cells and Metastasis
- Ubiquitin and proteasome pathways
- Epigenetics and DNA Methylation
- Metabolism, Diabetes, and Cancer
- Rheumatoid Arthritis Research and Therapies
- Bone and Dental Protein Studies
- Cancer-related Molecular Pathways
- Psoriasis: Treatment and Pathogenesis
- Histone Deacetylase Inhibitors Research
- Spondyloarthritis Studies and Treatments
- FOXO transcription factor regulation
- Ferroptosis and cancer prognosis
- Microtubule and mitosis dynamics
- Neuroblastoma Research and Treatments
- Protease and Inhibitor Mechanisms
Guangdong Laboratory Animals Monitoring Institute
2024-2025
Jinan University
2022-2024
Guangdong Medical College
2024
Triple-negative breast cancer (TNBC) is a highly lethal malignancy with limited therapy options. TWIST1, key transcriptional factor of epithelial-mesenchymal transition (EMT), contributes to self-renewal stem-like cells (CSCs), chemo-resistance, metastasis, and TNBC-related death. However, the mechanism by which TWIST1 deregulated in TNBC remains elusive. Here, USP29 identified as bona fide deubiquitinase TWIST1. The deubiquitination catalyzed required for its stabilization subsequent EMT...
Breast cancer is one of the most common malignancies in women worldwide. Triple-negative breast (TNBC) a highly aggressive and metastatic subtype that has characteristics easy recurrence, poor prognosis as well lack targeted therapeutics. Snail1, key factor regulating epithelial-mesenchymal transition (EMT) process, contributing to metastasis chemoresistance human cancers. However, molecular mechanism Snail1 stabilization cancers not fully understood. Here, we demonstrate deubiquitinating...
Triple-negative breast cancer (TNBC) is a highly lethal malignancy with limited therapy options. Aberrant metabolism, key hallmark of human cancers, plays crucial role in tumor progression, therapeutic responses and TNBC-related death. However, the underlying mechanisms are not fully understood. In this study, we delineate previously unrecognized aberrant glucose metabolism regulating turnover Snail1, which transcriptional factor epithelial-mesenchymal transition (EMT) critically contributes...
Abstract Pathological new bone formation is the main cause of disability in ankylosing spondylitis (AS), and so far, it lacks a targeted therapy. Macrophages are central orchestrators inflammation progression tissue remodeling, but their contribution to pathological has largely not been explored. Here, identified that TREM2 + macrophages predominated within sites adjacent osteogenic precursor cells. In vivo, both depletion knockout Trem2 significantly reduced collagen antibody‐induced...
Abstract Abnormalities in the extracellular matrix (ECM) play important roles regulation and progression of clear cell renal carcinoma (ccRCC). The cysteine cathepsin is one major proteases involved ECM remodeling has been shown to be aberrantly expressed multiple cancer types. However, clinical significance biological function distinct cathepsins ccRCC remain poorly understood. In this study, several bioinformatics databases, including UALCAN, TIMER, GEPIA Human Protein Atlas datasets, were...
Abstract The VHL protein (pVHL) functions as a tumor suppressor by regulating the degradation or activation of substrates such HIF1α and Akt. In human cancers harboring wild-type , aberrant downregulation pVHL is frequently detected critically contributes to progression. However, underlying mechanism which stability deregulated in these remains elusive. Here, we identify cyclin-dependent kinase 1 (CDK1) peptidyl-prolyl cis-trans isomerase NIMA-interacting (PIN1) two previously...