A5004518102- Systemic Lupus Erythematosus Research
- Rheumatoid Arthritis Research and Therapies
- Autoimmune and Inflammatory Disorders Research
- Spondyloarthritis Studies and Treatments
- Systemic Sclerosis and Related Diseases
- Psoriasis: Treatment and Pathogenesis
- Salivary Gland Disorders and Functions
- Monoclonal and Polyclonal Antibodies Research
- Atherosclerosis and Cardiovascular Diseases
- T-cell and B-cell Immunology
- Liver Diseases and Immunity
- Diabetes and associated disorders
- Galectins and Cancer Biology
- Immunodeficiency and Autoimmune Disorders
- Biosimilars and Bioanalytical Methods
- Cytokine Signaling Pathways and Interactions
- Lymphoma Diagnosis and Treatment
- Inflammatory Myopathies and Dermatomyositis
- Liver Disease Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Bone and Joint Diseases
- Allergic Rhinitis and Sensitization
- Pharmaceutical studies and practices
- Urticaria and Related Conditions
- Herbal Medicine Research Studies
Gannan Medical University
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2024
Peking Union Medical College Hospital
2015-2024
Northeast Agricultural University
2024
Academy of Medical Sciences
1990-2023
National Clinical Research
2020-2023
Ministry of Education of the People's Republic of China
2015-2023
National Clinical Research Center for Digestive Diseases
2021-2023
China-Japan Friendship Hospital
2014
Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences
2014
To characterize the clinical features of IgG4-related disease (IgG4-RD) in China.A prospective cohort study IgG4-RD was carried out Peking Union Medical College Hospital between 2011 and 2013. Patients with newly diagnosed were enrolled.A total 118 patients enrolled, including 82 males 36 females, aged 53.1 (s.d. 13.6) years. The most common symptom at onset lacrimal gland swelling (38/32.2%). A range organs involved: 77 (65.3%) had lymphadenopathy, 76 (64.4%) sialadenitis, 60 (50.8%)...
The Chinese systemic lupus erythematosus (SLE) treatment and research group (CSTAR) provides major clinical characteristics of SLE in China establishes a platform to provide resources for future basic studies. CSTAR originated as multicentre, consecutive, prospective design. data were collected online from 104 rheumatology centers, which covered 30 provinces China. registered patients required meet four or more the American College Rheumatology (ACR) criteria classification SLE. All centers...
To investigate the clinical features, outcome, and risk factors of disease flares in patients with pregnancy-related lupus (PRL).Medical charts 155 consecutive PRL inpatients were systematically reviewed, including demographic data, laboratory findings, treatment, complications, outcome.PRL cases divided into active (a-PRL) (n = 82, 53.0%) stable (s-PRL) 73, 47.0%). Compared nonpregnant female systemic erythematosus (SLE) patients, a-PRL new-onset (n-PRL) flare (f-PRL) 41 respectively), had...
Objectives Efficacy and safety of tofacitinib, an oral Janus kinase inhibitor, were evaluated in a 6-month, double-blind, phase 3 study Chinese patients with active (polyarthritic) psoriatic arthritis (PsA) inadequate response to ≥1 conventional synthetic disease-modifying antirheumatic drug. Methods Patients randomised (2:1) tofacitinib 5 mg twice daily (N=136) or placebo (N=68); switched after month (M)3 (blinded). Primary endpoint: American College Rheumatology (ACR50) at M3. Secondary...
We investigated the characteristics of Chinese SLE patients by analyzing association between specific autoantibodies and clinical manifestations 2104 from registry data CSTAR cohort. Significant (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mi>P</mml:mi><mml:mo><</mml:mo><mml:mn fontstyle="italic">0.05</mml:mn></mml:math>) associations were found anti-Sm antibody, anti-rRNP malar rash; anti-RNP anti-SSA pulmonary arterial hypertension (PAH); anti-SSB antibody...
Pulmonary arterial hypertension (PAH) is a life-threatening complication of systemic lupus erythematosus (SLE). However, there no algorithm to identify those at high risk. This study was undertaken develop prediction model for PAH in patients with that provides individualized risk estimates.A multicenter, longitudinal cohort from January 2003 2020. The collected data on 3,624 consecutively evaluated diagnosed as having SLE. diagnosis confirmed by right-sided heart catheterization. Cox...
Objective This study aims to exhibit the prognosis, both mortality and morbidity, of patients with systemic lupus erythematosus (SLE) in a single-center cohort China. Methods A Chinese SLE were recruited from April 2009 February 2010, followed up regularly clinic at Peking Union Medical College Hospital (PUMCH). Data for baseline, follow-up, survival collected, including demography, manifestations, activity, Systemic Lupus International Collaborating/American Rheumatology (SLICC/ACR) Damage...
Background WBP216 is a novel human immunoglobulin G1 (IgG1) monoclonal antibody for interleukin (IL)-6. We aimed to assess the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of single ascending dose (SAD) in patients with rheumatoid arthritis (RA). Methods In this double-blind, placebo-controlled, SAD, phase Ia study, RA were randomized 3:1 (Group A1, 10 mg) 6:2 A2, 30 mg; Group A3, 75 A4, 150 A5, 300 ratios receive either doses or placebo subcutaneously. The primary...
Objective. CD200/CD200R1 signalling has an immunoregulatory effect on the activation threshold of inflammatory immune response and maintains homeostasis. In this study we evaluated status interaction in patients with RA.