A5074771978- Cancer-related molecular mechanisms research
- Virus-based gene therapy research
- interferon and immune responses
- RNA Research and Splicing
- Circular RNAs in diseases
- Bioactive Natural Diterpenoids Research
- RNA modifications and cancer
- Renal Diseases and Glomerulopathies
- Ginger and Zingiberaceae research
- Tea Polyphenols and Effects
- Neuroinflammation and Neurodegeneration Mechanisms
- Blood groups and transfusion
- Metabolism, Diabetes, and Cancer
- Genetic Syndromes and Imprinting
- Central Venous Catheters and Hemodialysis
- RNA Interference and Gene Delivery
- Kruppel-like factors research
- MicroRNA in disease regulation
- Neurological Disease Mechanisms and Treatments
- Chronic Kidney Disease and Diabetes
- Autophagy in Disease and Therapy
- Cancer-related gene regulation
- Marine Sponges and Natural Products
- Vasculitis and related conditions
- Growth Hormone and Insulin-like Growth Factors
Gannan Medical University
2017-2025
Sun Yat-sen University
2017
Abstract The Warburg effect is an important characteristic of tumor cells, making it attractive therapeutic target. Current anticancer drug development strategies predominantly focus on inhibitors the specific molecular effectors involved in cell proliferation. These drugs or natural compounds, many which target and underlying mechanisms, still need to be characterized. To elucidate effects a diterpenoid, oridonin, we first demonstrated activity oridonin both vitro vivo colorectal cancer...
Abstract In view of the complicated pathophysiological process vascular dementia (VD), drugs for clinical treatment VD mainly target related risk factors, while with excellent efficacy in cognitive function are still relatively lacking. Imperatorin (IMP), an active constituent extracted from angelica dahuricae and notopterygium Notopterygii, which has anti-inflammatory, vasodilator, anticoagulant, block calcium channel, anticonvulsant, anti oxygen free radical injury properties....
The Warburg effect is prevalent in human cancer. Oridonin (ORI) has excellent anticancer effects, but its exact mechanism still unclear. CCK8, EdU, and flow cytometry assay were performed to detect the of ORI on cell viability, proliferation apoptosis, respectively. RNA-seq was carried out search underlying mechanisms. Total PKM2, dimeric nuclear PKM2 detected by Western blot. epidermal growth factor receptor/extracellular signal regulated kinase (EGFR/ERK) signaling assayed. binding ability...
To investigate the predictors of early diagnosis thrombus autogenous arteriovenous fistula (aAVF).
Abstract Background Lipoprotein glomerulopathy is a rare and newly recognized glomerular disease that can lead to kidney failure. Its pathological features include the presence of lipoprotein embolus in loop cavity capillaries. It believed apolipoprotein E gene mutation initiator disease. Since discovery glomerulopathy, 16 different mutations have been reported worldwide, but most these cases are sporadic. Here we report two Chinese son his father, with novel mutation, ApoE Ganzhou...
The fleshy fruits of Camellia oleifera Abel are the immature C. oleifera, which infected by Exobasidium vexans Massee and then turn to be intumescent hollowed. They contain rich trace elements vitamin C eaten directly as wild in Chinese countryside. Recent studies report that has anti-inflammatory antioxidative effects. current study, for first time, evaluates renal protective capacity polysaccharides from (CFFP) streptozotocin-induced diabetic mice fed high-fat diets. were orally...