A5100320905- Retinal Development and Disorders
- CRISPR and Genetic Engineering
- Retinal Diseases and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Alzheimer's disease research and treatments
- RNA Research and Splicing
- Glaucoma and retinal disorders
- Salivary Gland Disorders and Functions
- Photoreceptor and optogenetics research
- Tuberous Sclerosis Complex Research
- Neurological Disease Mechanisms and Treatments
- Cancer-related molecular mechanisms research
- Retinal Imaging and Analysis
- Visual perception and processing mechanisms
- Adipose Tissue and Metabolism
- Telomeres, Telomerase, and Senescence
- RNA regulation and disease
- Renal cell carcinoma treatment
- RNA modifications and cancer
- Ginseng Biological Effects and Applications
- Nuclear Receptors and Signaling
- Neuroscience and Neuropharmacology Research
- Vestibular and auditory disorders
- Lysosomal Storage Disorders Research
- Bone Metabolism and Diseases
Beijing Tongren Hospital
2005-2024
Capital Medical University
2021-2024
Union Hospital
2024
Huazhong University of Science and Technology
2024
State Key Laboratory of Information Engineering in Surveying Mapping and Remote Sensing
2024
Sichuan University
2024
State Key Laboratory of Biotherapy
2024
Jiangsu Academy of Agricultural Sciences
2019-2024
Tulane University
2021-2024
Renji Hospital
2024
Tobacco smoking is a leading cause of premature death in China, especially among adult men. Since the implementation Framework Convention on Control 2005, nationwide tobacco control has been strengthened, but its long-term impact prevalence unclear.Five nationally representative surveys China Chronic Disease and Risk Factor Surveillance (CCDRFS) were conducted 2007, 2010, 2013, 2015, 2018. A total 624,568 adults (278,605 men 345,963 women) aged 18 to 69 years randomly selected from 31...
Telomere length (TL) in surrogate tissues may be influenced by environmental exposures.We aimed to determine whether lifetime pesticides use is associated with buccal cell TL.We examined TL relation of 48 for 1,234 cancer-free white male pesticide applicators the Agricultural Health Study (AHS), a prospective cohort study 57,310 licensed applicators. Participants provided detailed information on 50 at enrollment (1993-1997). Buccal cells were collected from 1999 2006. Relative telomere (RTL)...
Abstract Telomeres are complexes of tandem repeats DNA (5′-TTAGGG-3′) and protein that cap eukaryotic chromosomes play a critical role in chromosome stability. shorten with aging this process can be accelerated by increased oxidative stress episodes inflammation. Evidence is rapidly growing telomere length (TL) may affected environmental chemicals have frequently been associated chronic diseases. In article, we review the published data on TL relation to occupational exposure several based...
PurposeRetinitis pigmentosa (RP) is a major cause of heritable human blindness with extreme genetic heterogeneity. A large number causative genes have been defined by next-generation sequencing (NGS). However, due to technical limitations, determining the existence uncovered or low-depth regions fundamental challenge in analyzing NGS data. Therefore, undetected mutations may exist genomic less effectively covered NGS.MethodsTo address this problem, we tested complementary approach for...
The epidemiological characteristics of Sjögren syndrome (SS) are significantly varied in different countries. We conducted the present study to survey primary SS China. recruited 483 patients from 16 Chinese medical centers nationwide January 2009 November 2011 and assessed salivary lacrimal gland dysfunction, organ involvement, autoimmunity these patients. cohort included 456 women 27 men (ratio, 17:1; mean age at onset, 42 ± 11 years; median diagnosis, 49 range, 41–56 years). Male showed a...
The aim of this study was to investigate the relationships among TRPV4, p38, and neuropathic pain in a rat model chronic compression dorsal root ganglion. Mechanical allodynia appeared after CCD surgery, enhanced via intrathecal injection 4α-phorbol 12,13-didecanoate (4α-PDD, an agonist TRPV4) anisomycin (an p38), but suppressed by Ruthenium Red (RR, inhibitor SB203580 p38). protein expressions p38 P-p38 were upregulated 4α-PDD reduced RR SB203580. Moreover, TRPV4 downregulated anisomycin....
Fasting induces lipid accumulation in the liver, while mechanisms by which fasting dysregulates liver fatty acid oxidation are not clear. Fatty ω-oxidation is induced state, and administration of dicarboxylic acids to animals decreases plasma ketone bodies. We hypothesized that endogenous might play a role controlling mitochondrial β-oxidation animals. A peroxisome proliferator-activated receptor-alpha agonist an inhibitor for peroxisomal were administered rats investigate homeostasis....
YAP is a transcriptional co-activator with critical roles in tumorigenesis. However, its upstream regulatory mechanism, especially how mRNA stability regulated, remains to be further studied. Here, we validated that expression was higher lung adenocarcinoma (LUAD) tissues compared adjacent normal tissues, and found m5C modification occurred 328-331 3' UTR region under the promotion NSUN2 ALYREF, increased of mRNA. This also inhibited miR-582-3p binding m6A nearby region. In addition,...
Abstract RB1 deficiency leads to retinoblastoma (Rb), the most prevalent intraocular malignancy. Tumor‐associated macrophages (TAMs) are related local inflammation disorder, particularly by increasing cytokines and immune escape. Microglia, unique resident for retinal homeostasis, important cells of Rb. However, whether affects microglial function remain unknown. In this study, microglia were successfully differentiated from Rb patient‐ derived human induced pluripotent stem (hiPSCs)...
The aim of the present study was to investigate whether MAPK pathways were involved in mechanism neuropathic pain rats with chronic compression dorsal root ganglion. We determined paw withdrawal mechanical threshold (PWMT) before and after CCD surgery then p38, JNK, or ERK inhibitors administration. Western blotting, RT-PCR, immunofluorescence ganglia performed protein mRNA level MAPKs also alternation distributions positive neurons ganglia. Intrathecal administration inhibitors, SB203580...
The BACE1 antisense transcript (BACE1-AS) is a conserved long noncoding RNA (lncRNA). level of BACE1-AS significantly increased and the mRNA slightly in subjects with AD. exerts significant moderating effect on expression promotes formation Aβ. After administration Aβ1-42 to SH-SY5Y cells C57/BL6J mice, we detected BACE1-AS, mRNA, protein, as well concentration Aβ1-40. Then, silenced 20E2 using siRNAs targeting its effects levels protein Aβ1-40 generation.The brains C57BL/6J mice....
Intrinsically disordered proteins (IDPs) SAID1/2 are hypothetic dentin sialophosphoprotein-like proteins, but their true functions unknown. Here, we identified as negative regulators of SERRATE (SE), a core factor in miRNA biogenesis complex (microprocessor). Loss-of-function double mutants said1; said2 caused pleiotropic developmental defects and thousands differentially expressed genes that partially overlapped with those se. also displayed increased assembly microprocessor elevated...
Stargardt Disease (STGD) is the commonest genetic form of juvenile or early adult onset macular degeneration, which a genetically heterogeneous disease. Molecular diagnosis STGD remains challenge in significant proportion cases. To address this, seven patients from five putative families were recruited. We performed capture next generation sequencing (CNGS) probands and searched for potentially disease-causing variants previously identified retinal dystrophy genes. Seven mutations ABCA4 two...
BACKGROUND:It is well known that, pathologically, Parkinson's disease a common neurodegenerative disorder. In disease, the protein which abundant in human brain, alpha-synuclein, accumulates inside nerve cells. this situation, dysregulation of lipid metabolism performs crucial role; however, its association with has not yet been explored. MATERIAL AND METHODS:We performed high-performance liquid chromatography-mass spectrometry-derived quantitative lipidomics study to analyze profile...