A5100373884- Traditional Chinese Medicine Analysis
- Cardiac Fibrosis and Remodeling
- Metabolomics and Mass Spectrometry Studies
- Peroxisome Proliferator-Activated Receptors
- Signaling Pathways in Disease
- Natural product bioactivities and synthesis
- Antimicrobial Peptides and Activities
- Traditional Chinese Medicine Studies
- Phytochemistry and Biological Activities
- Mitochondrial Function and Pathology
- Pharmacological Effects of Natural Compounds
- Autophagy in Disease and Therapy
- Invertebrate Immune Response Mechanisms
- Cancer Treatment and Pharmacology
- Sirtuins and Resveratrol in Medicine
- Viral gastroenteritis research and epidemiology
- Chemotherapy-induced cardiotoxicity and mitigation
- Cardiovascular Health and Risk Factors
- Cardiac Ischemia and Reperfusion
- interferon and immune responses
- Aquaculture disease management and microbiota
- Inflammasome and immune disorders
- NF-κB Signaling Pathways
- Atherosclerosis and Cardiovascular Diseases
- Bacteriophages and microbial interactions
Beijing University of Chinese Medicine
2016-2025
Guangzhou University of Chinese Medicine
2016-2025
Ji Hua Laboratory
2025
Fujian Medical University
2024-2025
First Affiliated Hospital of Fujian Medical University
2024-2025
Hunan Agricultural University
2023-2024
Anhui Medical University
2022-2024
First Affiliated Hospital of Anhui Medical University
2022-2024
Peking University People's Hospital
2014-2024
Peking University
2014-2024
Abstract Traditional Chinese Medicine (TCM), with a history of thousands years clinical practice, is gaining more and attention application worldwide. And TCM-based new drug development, especially for the treatment complex diseases promising. However, owing to TCM’s diverse ingredients their interaction human body, it still quite difficult uncover its molecular mechanism, which greatly hinders TCM modernization internationalization. Here we developed first online Bioinformatics Analysis...
Metagenomic next-generation sequencing (mNGS) was suggested to potentially replace traditional microbiological methodology because of its comprehensiveness. However, clinical experience with application the test is relatively limited. From April 2017 December 2017, 511 specimens were collected, and their retrospective diagnoses classified into infectious disease (347 [67.9%]), noninfectious (119 [23.3%]), unknown cases (45 [8.8%]). The diagnostic performance pathogens compared between mNGS...
LRRK2 was previously identified as a defective gene in Parkinson's disease, and it is also located risk region for Crohn's disease. In this study, we aim to determine whether could be involved immune responses. We show that expression enriched human cells. an IFN-γ target gene, its increased intestinal tissues upon disease inflammation. inflamed tissues, detected the lamina propria macrophages, B-lymphocytes, CD103-positive dendritic Furthermore, enhances NF-κB-dependent transcription,...
Importance To our knowledge, there has been no update on the prevalence of chronic kidney disease (CKD) in China since 2012. Objective provide periodic nationwide data CKD and associated behavioral metabolic risk factors China. Design, Setting, Participants This nationally representative cross-sectional study included from 176 874 adults all 31 provincial-level administrative divisions mainland China, as reported sixth Chronic Disease Risk Factor Surveillance conducted August 2018 to June...
Abstract Objective To assess the recent trends in prevalence and management of hypertension China, nationally by population subgroups. Design Six rounds a national survey, China. Setting China Chronic Disease Risk Factors Surveillance, 2004-18. Participants 642 523 community dwelling adults aged 18-69 years (30 501 2004, 47 353 2007, 90 491 2010, 156 836 2013, 162 293 2015, 155 049 2018). Main outcome measures Hypertension was defined as blood pressure ≥140/90 mm Hg or taking...
Tobacco smoking is a leading cause of premature death in China, especially among adult men. Since the implementation Framework Convention on Control 2005, nationwide tobacco control has been strengthened, but its long-term impact prevalence unclear.Five nationally representative surveys China Chronic Disease and Risk Factor Surveillance (CCDRFS) were conducted 2007, 2010, 2013, 2015, 2018. A total 624,568 adults (278,605 men 345,963 women) aged 18 to 69 years randomly selected from 31...
Small-molecule immune potentiators can be engineered to potent adjuvants with localized innate activation and short in vivo residence times.
Heart failure (HF) leads to an increase in morbidity and mortality globally. Tanshinone IIA is important traditional Chinese medicine monomer has been shown have remarkable protective effect against HF. Autophagy critically involved the progression of The on autophagy not clarified yet. In this study, left anterior descending (LAD) ligation was used induce HF model a hydrogen peroxide-(H2O2-)-induced H9C2 cell injury established. vivo, echocardiography results showed that could significantly...
Regulatory T cells (Tregs) with the plasticity of producing proinflammatory cytokine IL-17 have been demonstrated under normal and pathogenic conditions. However, it remains unclear whether IL-17-producing Tregs lose their suppressive functions because toward Th17 in autoimmunity. The aim this study was to investigate from patients rheumatoid arthritis (RA), characterise regulatory capacity clinical significance.Foxp3 coexpression were evaluated CD4 lymphocytes RA patients. An vitro cell...
Cardiac fibrosis is a common pathological progress of cardiovascular disease resulting from the excessive accumulation extracellular matrix (ECM). Transforming growth factor (TGF)-β/SMADs pathway canonical signaling which directly induces expressions ECM related genes. Qishen Granule (QSG), traditional Chinese formula developed Zhen-Wu Decoration for heart failure (HF), has been proven to have definite therapeutic effects on cardiac fibrosis. However, its underlying mechanisms remain...
Doxorubicin is effective in a variety of solid and hematological malignancies. Unfortunately, clinical application doxorubicin limited due to cumulative dose-dependent cardiotoxicity. Dihydrotanshinone I (DHT) natural product from Salvia miltiorrhiza Bunge with multiple anti-tumor activity anti-inflammation effects. However, its anti-doxorubicin-induced cardiotoxicity (DIC) effect, either vivo or vitro, has not been elucidated yet. This study aims explore the effects DHT against DIC,...
Polyunsaturated fatty acid-derived oxylipins regulate systemic inflammation and exert cardiovascular effects, yet their role in ST-segment elevation myocardial infarction (STEMI) remains unclear. Herein, we used targeted metabolomics machine learning algorithms to develop an oxylipin-based risk model accurately predict recurrent major adverse events (MACE) after STEMI two independent prospective cohorts with 2 years of follow-up. The vivo effects significant oxylipin predictors were explored...
The issues of reducing CO2 levels in the atmosphere, sustainably utilizing natural mineral resources, and dealing with industrial waste offer challenging opportunities for sustainable development energy environment. latest advances mineralization technology involving minerals are summarized this paper, great emphasis on advancement fundamental science, economic evaluation, engineering applications. We discuss several leading large-scale methodologies from a technical engineering-science...
The vascular endothelial growth factor (VEGF) signaling pathway involved in angiogenesis which plays a pivotal role normal development and also represents major therapeutic target for tumors intraocular neovascular disorders. aims of the present study were to evaluate effects VEGF on cells clarify mechanism. Here, we showed that significantly stimulated proliferation, migration cell cycle cells, it induced tube formation vitro significantly. What's more, mitochondrial functions enhanced...
Clinical use of the anti-cancer drug doxorubicin (DOX) is largely limited due to its severe cardiotoxicity. Dysregulation autophagy implicated in DOX-induced cardiotoxicity (DIC). Prior studies have indicated that Beclin1 and lysosomal-associated membrane proteins-1 (LAMP1) are critical mediators autophagy. In this work, by assessing autophagic flux a DOX-stimulated H9C2 model, we observed autolysosome accumulation caused interruption degradation. Tanshinone IIA (TSA) well-known small...
Viral seasonality in the aquaculture industry is an important scientific issue for decades. While molecular mechanisms underpinning temperature-dependent pathogenesis of aquatic viral diseases remain largely unknown. Here we report that activation IL6-STAT3 signaling was exploited by grass carp reovirus (GCRV) to promote entry via increasing expression heat shock protein 90 (HSP90). Deploying GCRV infection as a model system, discovered induces IL6-STAT3-HSP90 achieve entry. Further...