A5014563364- Peroxisome Proliferator-Activated Receptors
- Traditional Chinese Medicine Analysis
- Ginseng Biological Effects and Applications
- Autophagy in Disease and Therapy
- Endoplasmic Reticulum Stress and Disease
- Adipose Tissue and Metabolism
- Cancer-related molecular mechanisms research
- Pharmacological Effects of Natural Compounds
- Cardiac Fibrosis and Remodeling
- Atherosclerosis and Cardiovascular Diseases
- Cancer, Lipids, and Metabolism
- Metabolomics and Mass Spectrometry Studies
- Traditional Chinese Medicine Studies
- Nuclear Receptors and Signaling
- Adenosine and Purinergic Signaling
- Sirtuins and Resveratrol in Medicine
- Electron Spin Resonance Studies
- Mitochondrial Function and Pathology
- NF-κB Signaling Pathways
- Signaling Pathways in Disease
- Estrogen and related hormone effects
- Sphingolipid Metabolism and Signaling
- Liver Disease Diagnosis and Treatment
- Flavonoids in Medical Research
- Medicinal Plants and Bioactive Compounds
Beijing University of Chinese Medicine
2017-2025
Qingdao Institute of Marine Geology
2024
Heart failure (HF) leads to an increase in morbidity and mortality globally. Tanshinone IIA is important traditional Chinese medicine monomer has been shown have remarkable protective effect against HF. Autophagy critically involved the progression of The on autophagy not clarified yet. In this study, left anterior descending (LAD) ligation was used induce HF model a hydrogen peroxide-(H2O2-)-induced H9C2 cell injury established. vivo, echocardiography results showed that could significantly...
Heart failure (HF) leads to an increase in morbidity and mortality globally. Disorders of energy metabolism apoptosis cardiomyocytes are critically involved the progression HF. Ginsenoside Rb3 (G-Rb3) is a natural product derived from ginseng that has cardio-protective effect. The pharmacological mechanism G-Rb3 treatment HF remains be clarified. In this study, we aimed explore regulative effects on fatty acids oxidation by vivo vitro studies. Myocardial infarction (MI)-induced mice model...
Clinical use of the anti-cancer drug doxorubicin (DOX) is largely limited due to its severe cardiotoxicity. Dysregulation autophagy implicated in DOX-induced cardiotoxicity (DIC). Prior studies have indicated that Beclin1 and lysosomal-associated membrane proteins-1 (LAMP1) are critical mediators autophagy. In this work, by assessing autophagic flux a DOX-stimulated H9C2 model, we observed autolysosome accumulation caused interruption degradation. Tanshinone IIA (TSA) well-known small...
Aims : Cardiac lipotoxicity is the common consequence of lipid metabolism disorders in cardiomyocytes during development heart failure (HF). Adenosine 5′monophosphate-activated protein kinase (AMPK) acts as an energy sensor and has a beneficial effect reducing lipotoxicity. Notoginsenoside R1 (NGR1) extracted from traditional Chinese medicine Panax notoginseng (Burkill) F.H.Chen ( P. ) definite cardioprotective effects. However, whether NGR1 can attenuate HF by mitigating not been elucidated...
Aim: Danqi pill (DQP), a Chinese medicine frequently prescribed in China, has been approved to improve cardiac function by regulating energy metabolism heart failure (HF) after acute myocardial infarction (AMI) patients. The aim of this study was explore whether the mechanism DQP is associated lipid and glucose mediated via PPARγ (peroxisome proliferator-activated receptor γ) pathway both vivo vitro. Methods Materials: Model HF AMI established with ligation left anterior descending artery on...
Retinoid X receptor alpha (RXRα) is a nuclear transcription factor that extensively regulates energy metabolism in cardiovascular diseases. Identification of targeted RXRα drugs for heart failure (HF) therapy urgently needed. Neocryptotanshinone (NCTS) component derived from Salvia miltiorrhiza Bunge, the effect and mechanism which treating HF have not been reported. The goal this study was to explore pharmacological effects NCTS on protect against post-acute myocardial infarction (AMI) via...
Coronary artery disease (CAD) is one of the leading causes deaths worldwide. Energy metabolism disorders, including a reduction in fatty acids oxidation and upregulation glycolysis pathway, are involved process CAD. Therapeutic angiogenesis has become promising treatment for Traditional Chinese medicines, such as Danqi Pill (DQP), have been proven to be effective treating CAD China many years. However, pro-angiogenic effects DQP based on still unknown mechanism worthy investigation. In this...
A smart nanoplatform with doxorubicin (DOX) and simvastatin (SV) was fabricated by encapsulating both drugs in a polyphenol-based polymer for chemotherapy MRI/PET imaging.
Background: Acute myocardial ischemia (AMI) is a common heart disease with increasing morbidity and mortality year by year. Persistent sterile inflammatory infiltration of tissue an important factor triggering acute secondary to infarction, NLRP3 inflammasome activation part response after ischemia. Previous studies have shown that Qishen granule (QSG) can significantly inhibit the injury caused ischemia, but its effect specific mechanism inhibiting not been reported. This study was...
Abstract Objective: This study aimed to explore the mechanism of Panax notoginseng (PNS) in treatment heart failure (HF) based on network pharmacology analysis combined with experimental verification. Materials and Methods: The potential targets key pathways effective components PNS HF were revealed using pharmacology. postacute myocardial infarction (MI) rat model was established by ligating left anterior descending branch coronary artery. rats divided into three groups: model, PNS,...
Danqi pill (DQP) is a widely prescribed traditional Chinese medicine (TCM) in the treatment of cardiovascular diseases. The objective this study to systematically characterize altered gene expression pattern induced by myocardial ischemia (MI) rat model and investigate effects DQP on global expression. Global mRNA was measured. Differentially expressed genes among sham group, group were analyzed. ontology enrichment analysis pathway differentially carried out. We quantified 10,813 genes....