A5038981689- Adipose Tissue and Metabolism
- Ginseng Biological Effects and Applications
- Peroxisome Proliferator-Activated Receptors
- Traditional Chinese Medicine Analysis
- Metabolomics and Mass Spectrometry Studies
- Hippo pathway signaling and YAP/TAZ
- Receptor Mechanisms and Signaling
- Cardiovascular Function and Risk Factors
- Chemotherapy-induced cardiotoxicity and mitigation
- Acupuncture Treatment Research Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Cancer Treatment and Pharmacology
- NF-κB Signaling Pathways
- Endoplasmic Reticulum Stress and Disease
- Electron Spin Resonance Studies
- Cytokine Signaling Pathways and Interactions
Beijing University of Chinese Medicine
2018-2023
Heart failure (HF) leads to an increase in morbidity and mortality globally. Disorders of energy metabolism apoptosis cardiomyocytes are critically involved the progression HF. Ginsenoside Rb3 (G-Rb3) is a natural product derived from ginseng that has cardio-protective effect. The pharmacological mechanism G-Rb3 treatment HF remains be clarified. In this study, we aimed explore regulative effects on fatty acids oxidation by vivo vitro studies. Myocardial infarction (MI)-induced mice model...
Abstract Background Qishen granules (QSG) has been applied to treat heart failure (HF) for decades. Our previous transcriptomics study suggested that could regulate the pathways of cardiac energy metabolism in HF, but specific regulatory mechanism not yet clarified. This was investigate potential QSG regulating myocardial fatty acid (FA) and glucose a rat model HF. Methods The HF induced by left anterior descending coronary artery ligation. Cardiac structure function were assessed cine...
Qishen granules (QSG) are a famous formula with cardioprotective properties to heart failure (HF). The aim of this study was investigate the underlying mechanism QSG on apoptosis and fibrosis in treatment HF. HF model induced by left anterior descending artery ligation Sprague-Dawley rats. Transcriptome analysis used regulatory pathways Interestingly, downregulated genes were significantly enriched Hippo pathway which plays crucial role regulating cell proliferation. We found that inhibited...
Background: To investigate the active ingredients and mechanisms of Si-miaoyong- an Decoction (SMYA) in treatment coronary heart disease (CHD) by using network pharmacology, molecular docking technology, vitro validation. Methods: Through Chinese Medicine System Pharmacology Database Analysis Platform (TCMSP), Uniprot database, GeneCards DAVID we explored core compounds, targets signal pathways effective compounds SMYA CHD. Molecular technology was applied to evaluate interactions between...
A causal relationship between ginsenoside Rb3 (G-Rb3) and improved inflammation cardiac function has not been established. To determine which specific signaling pathways were involved in G-Rb3 improvement of myocardial function. In vivo, we found that decreased the levels both nuclear factor κB (NF-κB p65) CD45, an inflammatory marker. also enhanced key proteins contraction unit (cardiac troponin protein I (cTnI) α-actinin) to improve inhibited NF-κB p65 translocation vitro, as verified by...