A5100780730- Peroxisome Proliferator-Activated Receptors
- Kruppel-like factors research
- Adipose Tissue and Metabolism
- Cancer, Lipids, and Metabolism
- Fibroblast Growth Factor Research
- Reproductive Biology and Fertility
- Lipid metabolism and biosynthesis
- Cancer-related gene regulation
- RNA Research and Splicing
- Cancer-related molecular mechanisms research
- Lipid metabolism and disorders
- Cancer, Hypoxia, and Metabolism
- Bacteriophages and microbial interactions
- Genetic and phenotypic traits in livestock
- MicroRNA in disease regulation
- Adipokines, Inflammation, and Metabolic Diseases
- Traditional Chinese Medicine Analysis
- Renal and related cancers
- Epigenetics and DNA Methylation
- Antibiotic Resistance in Bacteria
- Metabolomics and Mass Spectrometry Studies
- Metabolism and Genetic Disorders
- RNA modifications and cancer
- Aquaculture disease management and microbiota
- Receptor Mechanisms and Signaling
Nanjing University
2015-2025
State Key Laboratory of Analytical Chemistry for Life Science
2024-2025
Southwest Minzu University
2014-2024
Zunyi Medical University
2024
Chengdu Women's and Children's Central Hospital
2023
University of Electronic Science and Technology of China
2023
Anhui Medical University
2019-2023
China Medical University
2023
Chinese Center For Disease Control and Prevention
2023
Chinese People's Liberation Army
2023
Abstract Background Non-thyroidal illness syndrome is commonly observed in critically ill patients, characterized by the inactivation of systemic thyroid hormones (TH), which aggravates metabolic dysfunction. Recent evidence indicates that enhanced TH mediated reactivation type 3 deiodinase (Dio3) at tissue level, culminating a perturbed local equilibrium. This study assessed whether targeted inhibition Dio3 can maintain homeostasis under septic conditions and explored mechanism behind...
Silent Information Regulator 5 (SIRT5) has been established as a crucial regulator of cellular alanylation modification. Furthermore, accumulating evidence suggests that SIRT5 plays significant regulatory role in key metabolic pathways, including glycolysis, the tricarboxylic acid (TCA) cycle, and fatty oxidation, all which are closely associated with lipid metabolism. Despite these advancements, specific regulating intramuscular fat (IMF) deposition goats, well underlying molecular...
Basalt fiber has been proved to be a good modified material for asphalt mixture. The performance of basalt mixture widely investigated by extensive researches. However, most studies focused on ordinary static load tests, and less attention was paid the dynamic mechanical response incorporating with fiber. This paper aims establish master curve complex modulus styrene-butadiene-styrene (SBS) polymer using generalized Sigmoidal model. Both loading frequency temperature were In addition, based...
The activation function 2 (AF-2)-dependent recruitment of coactivator is essential for gene by nuclear receptors. We show that the peroxisome proliferator-activated receptor γ (PPARγ) (NR1C3) coactivator-1 (PGC-1) requires both intact AF-2 domain PPARγ and LXXLL PGC-1 ligand-dependent ligand-independent interaction coactivation. Although absolutely required PGC-1-mediated coactivation, this displayed a unique lack requirement charge clamp ligand-binding thought to be motif recognition....
The TGF-β superfamily members are indicated to play key roles in ovarian follicular development, such as granulosa cell proliferation, estrogens, and progesterone production. However, little is known about the of TGF-β3 development. In this study, we found that was predominantly expressed cells mouse follicles, it significantly promoted 17β-estradiol (E2) release a dose-dependent manner. orphan nuclear receptor steroidogenic factor-1 (SF-1) required TGF-β3-induced Cyp19a1 (a rate-limiting...
The identification of suitable reference genes is critical for obtaining reliable results from gene expression studies using quantitative real-time PCR (qPCR) because the may vary considerably under different experimental conditions. In most cases, however, commonly used are employed in data normalization without proper validation, which lead to incorrect interpretation. Here, we aim select a set optimal accurate associated with intramuscular fat (IMF) deposition during development. present...
Intramuscular fat (IMF) deposition is one of the most important factors affecting meat quality and closely associated with expression carnitine palmitoyl transferase 1A (CPT1A) which facilitates transfer long-chain fatty acids (LCFAs) into mitochondria. However, role how CPT1A regulates IMF formation remains unclear. Herein, we established temporal profile during differentiation goat intramuscular precursor adipocytes. Functionally, knockdown by siRNA treatment significantly increased mRNA...
Following myocardial infarction (MI), peri-infarct edema formation further impairs cardiac function. Extracellular RNA (eRNA) released from injured cells strongly increases vascular permeability. This study aimed to assess the role of eRNA in MI-induced formation, infarct size, function, and survival after acute MI evaluate therapeutic potential ribonuclease 1 (RNase-1) treatment as an eRNA-degrading intervention.C57BL/6J mice were subjected by permanent ligation left anterior descending...
The resistance of carbapenem-resistant Klebsiella pneumoniae (CRKP) to colistin has become a major challenge in clinics. objective this study was investigate the synergistic and bactericidal effects combinations with meropenem amikacin vitro provide laboratory data required for treatment CRKP infections Eastern Heilongjiang Province. minimum inhibitory concentrations antibiotics were determined by micro-broth dilution method against 40 isolates. Ten isolates selected determine concentration....
Obesity is one of the leading causes insulin resistance. Accumulating reports have highlighted that serum amyloid A-1 (SAA1) a potential candidate capable attenuating Hence, we conducted current study with aims investigating our proposed hypothesis silencing SAA1 could inhibit progression obesity-induced resistance through NF-κB pathway. Gene expression microarray analysis was initially performed to screen differentially expressed genes (DEGs) associated obesity. Palmitate (PA)-induced Huh7...
Abnormal epigenetic reprogramming of the donor nucleus after somatic cell nuclear transfer (SCNT) is thought to be main cause low cloning efficiency. Following SCNT, often fails express early embryonic genes and establish a normal pattern chromatin modification. Therefore, in this study, we have attempted improve cloned embryos with Zebularine Scriptaid. Yak fibroblasts were treated 20 μM alone or plus 0.5 Scriptaid for 24 h, whereas yak exclusively 12 h. There was no effect on cellular...
This research communication describes the profile of gene expression related to synthesis yak milk as determined via quantitative reverse transcription polymerase chain reaction (RT-qPCR). Significant up-regulation during lactation were observed in genes fatty acid (FA) uptake from blood ( LPL, CD36 ), intracellular FA transport FABP3 activation long- and short-chain FAs ACSS1, ACSS2, ACSL1 de novo ACACA desaturation SCD triacyglycerol (TAG) AGPAT6 , GPAM, LPIN1 lipid droplet formation...
Breast cancer (BC) is the most prevalent among women worldwide. Although advances have been made in identification of predictive biomarkers, current options for early diagnosis and prognostic analysis are still suboptimal. Recently, transfer-RNA-derived RNA fragments (tRFs) emerged as a class small noncoding RNAs that play role progression. The authors aimed to identify specific tRFs molecular marker BC prognosis clinical management.
Mycoplasma ovipneumoniae is associated with chronic nonprogressive pneumonia in both sheep and goats. Studies concerning its molecular pathogenesis, genetic analysis, vaccine development have been hindered due to limited genomic information. Here, we announce the first complete genome sequence of this organism.
Danqi Pill (DQP), which contains Chinese herbs Salvia miltiorrhiza Bunge and Panax notoginseng, is widely used in the treatment of myocardial ischemia (MI) China. Its regulatory effects on MI-associated lipid metabolism disorders haven't been comprehensively studied so far. We aimed to systematically investigate mechanism DQP ischemia-induced disorders. Myocardial rat model was induced by left anterior descending coronary artery ligation. The models were divided into three groups: group with...
The yak is primarily found throughout the Tibetan high plateau and surrounding mountainous area of south central Asia; among its others attributes, milk very important for local population. A key concern in field research better understanding which genes control production composition milk. most accurate sensitive method gene expression analysis quantitative reverse transcription polymerase chain reaction (RT-qPCR). It essential reliable RT-qPCR to be able normalize data using internal...
Fibroblast growth factor 21 (FGF21) plays a critical role in the regulation of lipid metabolism; however, its function goat intramuscular fat (IMF) deposition remains unknown. To explore FGF21 for IMF deposition, we performed gain and loss adipocyte. Our results showed that overexpression mediated by adenovirus inhibits accumulation adipocyte, accompanied down-regulating mRNA levels peroxisome proliferator activated receptor γ (PPARγ), adipocyte fatty acid-binding protein 2 (aP2) sterol...
DanQi pill (DQP) is prescribed widely in China and has definite cardioprotective effect on coronary heart disease. Our previous studies proved that DQP could effectively regulate plasma levels of high density lipoprotein (HDL) low (LDL). However, the regulatory mechanisms its major components Salvianolic acids Panax notoginseng saponins (DS) lipid metabolism disorders haven't been comprehensively studied so far. Rat model disease was induced by left anterior descending (LAD) artery ligation...
Abstract: Buchang NaoXinTong (NXT) is a Chinese medicine that has been used for many years treatment of patients with coronary heart disease (CHD) in China. Statins substantially reduce hypercholesterolemia and CHD mortality morbidity. However, there still lot who do not respond well to statin therapy. Herein, we report the effects NXT on atorvastatin-inhibited atherosclerosis atorvastatin-induced hepatic side effects. After 10 weeks high-fat diet (HFD) feeding, apoE-deficient mice were...