A5082421982- Cancer-related molecular mechanisms research
- Cancer, Lipids, and Metabolism
- RNA modifications and cancer
- Neonatal Respiratory Health Research
- Gastric Cancer Management and Outcomes
- MicroRNA in disease regulation
- Cancer Genomics and Diagnostics
- Cystic Fibrosis Research Advances
- Peroxisome Proliferator-Activated Receptors
- RNA Research and Splicing
- Molecular Biology Techniques and Applications
- Protease and Inhibitor Mechanisms
- Circular RNAs in diseases
- Nutrition, Genetics, and Disease
- Epigenetics and DNA Methylation
- Metabolism, Diabetes, and Cancer
- Cancer, Hypoxia, and Metabolism
- Renal and Vascular Pathologies
- Cancer-related gene regulation
- Metastasis and carcinoma case studies
- Helicobacter pylori-related gastroenterology studies
- Receptor Mechanisms and Signaling
- Sarcoma Diagnosis and Treatment
- Gut microbiota and health
- Genomic variations and chromosomal abnormalities
Sun Yat-sen University
2010-2025
Sun Yat-sen Memorial Hospital
2025
National Clinical Research Center for Digestive Diseases
2025
Xijing Hospital
2024
Wuhan University
2013-2024
Fujian Medical University
2010-2024
Beijing Institute of Technology
2002-2024
First Affiliated Hospital of Fujian Medical University
2020-2024
Third Affiliated Hospital of Guangzhou Medical University
2019-2024
Guangzhou Medical University
2019-2024
Background & AimsIntratumor heterogeneity and divergent clonal lineages within among primary recurrent hepatocellular carcinomas (HCCs) produce challenges to patient management. We investigated genetic epigenetic variations liver tumors, hepatic lesions, between relapsing tumors.MethodsTumor matched nontumor specimens were collected from 113 patients who underwent partial hepatectomy for or HCC at 2 hospitals in Hong Kong. performed whole-genome, whole-exome, targeted capture sequencing...
Balanced chromosomal rearrangement (or balanced chromosome abnormality, BCA) is a common structural variation. Next-generation sequencing has been reported to detect BCA-associated breakpoints with the aid of karyotyping. However, complications associated this approach and requirement for cytogenetics information limited its application. Here, we provide whole-genome low-coverage BCA events independent knowing affected regions low false positives. First, six samples containing BCAs were used...
Alternative splicing (AS) allows generation of cell type–specific mRNA transcripts and contributes to hallmarks cancer. Genome‐wide analysis for AS in human hepatocellular carcinoma (HCC), however, is limited. We sought obtain a comprehensive landscape HCC define tumor‐associated variants. Single‐molecule real‐time long‐read RNA sequencing was performed on patient‐derived cells, presence splice junctions defined by SpliceMap‐LSC‐IDP algorithm. obtained an all‐inclusive map annotated variants...
<title>Abstract</title> Background The relationship between vitamin D levels and the risk of kidney diseases, such as IgA nephropathy (IgAN), membranous (MN), diabetic (DN), is still debated in observational studies. This research aims to evaluate causal relationships these diseases using a bidirectional Mendelian randomization (MR) approach. Methods We obtained summary-level data from genome-wide association studies (GWAS) on serum 25(OH)D levels, IgAN, MN, DN assess impact diseases....
Acute lung injury (ALI) causes inflammation and edema as well resulting in gut microbiota disorder. Probiotics, however, can improve the composition modulate its immune response, playing an important role ALI pathogenesis. Therefore, our study aims to investigate effect of Lactobacillus reuteri on Lipopolysaccharide (LPS)-induced mice probe mechanism synergistic modulatory lungs intestines. We assessed therapeutic effects L. mouse model by histopathology, alveolar lavage fluid serum...
Abstract Cystic fibrosis (CF) is an autosomal recessive disorder caused by mutations of the cystic transmembrane conductance regulator (CFTR), a cAMP‐dependent anion channel mostly expressed in epithelia. Accumulating evidence suggests that CF airway epithelia are overwhelmed excessive inflammatory cytokines and prostaglandins (PGs), which eventually lead to over‐inflammatory condition observed lung disease. However, exact underlying mechanism remains elusive. In this study, we increased...
In our previous study, we have demonstrated that the epithelial sodium channel (ENaC) mediates embryo-derived signals leading to activation of CREB and upregulation cyclooxygenase type 2 (COX2) required for embryo implantation. This study aims investigate whether microRNAs (miRNAs) are involved in ENaC-induced COX2 during The results show levels miR-101 miR-199a-3p, two targeting miRNAs, reduced by ENaC activation, increased inhibition or knock-down subunit (ENaCα) human endometrial surface...
Previous studies have found that inappropriate elevation of matrix metalloproteinase-9 (MMP9) expression and activity is coincident with early onset emphysema in Smad3-null mice. Herein, we further investigated the role increased MMP9 pathogenesis related molecular regulatory mechanisms elevated lung. Genetic blockade mice significantly attenuated pathology but not hypoalveolarization during postnatal lung development. Furthermore, Smad3 was to be a transcription factor positively regulate...
MicroRNA-224 has been proven dysregulated in some human malignancies and correlated with tumor progression. However, its expression clinical significance non-small cell lung cancer (NSCLC) is still unclear. Thus, the aim of this study was to explore effects miR-224 NSCLC tumorigenesis development.Using real-time quantitative RT-PCR, we detected lines primary tissues. The association clinicopathological factors prognosis also statistically analyzed. MTT, flow cytometric, Transwell invasion...
The cystic fibrosis transmembrane conductance regulator (CFTR) plays a critical role in electrolyte and fluid transport epithelial cells, women with (CF), caused by CFTR gene mutations, have higher incidence of infertility.In the present study, we investigated expression porcine oviduct its functional oviductal HCO(3)(-) secretion embryo development RT-PCR, western blot, patch-clamp, short-circuit current (I(sc)), pH measurement culture.RT-PCR blot analysis showed mRNA protein localization...