A5017431965- Prenatal Screening and Diagnostics
- Genomic variations and chromosomal abnormalities
- MicroRNA in disease regulation
- Fetal and Pediatric Neurological Disorders
- Genomics and Rare Diseases
- Congenital heart defects research
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Chromosomal and Genetic Variations
- Pelvic floor disorders treatments
- RNA modifications and cancer
- Cancer-related Molecular Pathways
- Cancer-related gene regulation
- Genetic Syndromes and Imprinting
- Parvovirus B19 Infection Studies
- Glaucoma and retinal disorders
- Retinal Development and Disorders
- Ocular Oncology and Treatments
- Renal and related cancers
- Genetics and Neurodevelopmental Disorders
- Retinal Diseases and Treatments
- Cancer Genomics and Diagnostics
- Corneal Surgery and Treatments
- Congenital Anomalies and Fetal Surgery
- Hearing, Cochlea, Tinnitus, Genetics
Chinese University of Hong Kong
2016-2025
Chinese University of Hong Kong, Shenzhen
2016-2025
Ideaya Biosciences (United States)
2025
Prince of Wales Hospital
2014-2024
University of Hong Kong
2013-2023
Tufts Medical Center
2020
Shanghai First Maternity and Infant Hospital
2020
National and Kapodistrian University of Athens
2020
Universidad de Los Andes, Chile
2020
Maastricht University
2020
The implementation of chromosomal microarray analysis (CMA) in prenatal testing for all patients has not achieved a consensus. Technical alternatives such as Prenatal BACs-on-Beads(TM) (PNBoBs(TM) ) have thus been applied. aim this study was to provide the frequencies submicroscopic defects detectable by PNBoBs(TM) under different indications.A total 9648 samples were prospectively analyzed karyotyping plus and classified indication. genomic their 95%CIs calculated each indication.The...
Congenital scoliosis is a common type of vertebral malformation. Genetic susceptibility has been implicated in congenital scoliosis.
Abstract Purpose: This study aims to profile the expressions of 156 microRNAs (miRNA) in hepatocellular carcinoma (HCC) and characterize functions miR-222, most significantly upregulated candidate identified. Experimental Design: miRNA expression HCC tumors, matching adjacent cirrhotic livers, cell lines was conducted using quantitative PCR. Common miR-222 upregulations were further validated a larger cohort tumors. The functional effects inhibition on examined. downstream modulated pathways...
The respective production of specific immunoglobulin (Ig)G2a or IgG1 within 5 d primary immunization with Swiss type mouse mammary tumor virus [MMTV(SW)] haptenated protein provides a model for the development T helper 1 (Th1) and Th2 responses. antibody-producing cells arise from cognate cell B interaction, revealed by induction Cγ2a Cγ1 switch transcript production, on third day after immunization. proliferation upregulation mRNA interferon γ in response to MMTV(SW) interleukin 4 also...
Enhancer of zeste homolog 2 (EZH2) is the catalytic subunit Polycomb-repressive complex (PRC2) that represses gene transcription through histone H3 lysine 27 trimethylation (H3K27me3). Although EZH2 abundantly present in various cancers, molecular consequences leading to oncogenesis remain unclear. Here, we show concordantly silences Wnt pathway antagonists operating at several subcellular compartments, which turn activate Wnt/β-catenin signaling hepatocellular carcinomas (HCC). Chromatin...
Chromosomal microarray analysis is the gold standard for copy-number variant (CNV) detection in prenatal and postnatal diagnosis. We aimed to determine whether next-generation sequencing (NGS) technology could be an alternative method CNV routine clinical application.Genome-wide (>50 kb) was performed on a multicenter group of 570 patients using low-coverage whole-genome pipeline. These samples were referred chromosomal analysis; CNVs (i.e., pathogenic CNVs, pCNVs) classified according...
As a distinct type of head and neck cancer, non-keratinizing nasopharyngeal carcinoma (NPC) is closely associated with EBV infection massive lymphoid infiltration. The unique histological features suggest that local inflammation plays an important role in NPC tumourigenesis. We comprehensively characterized NF-κB signalling, key inflammatory pathway which might contribute to the tumourigenesis this EBV-associated cancer. By EMSA, western blotting, immunohistochemical staining, constitutive...
ABSTRACT Objective To report secondary or additional findings arising from introduction of non‐invasive prenatal testing (NIPT) for aneuploidy by whole genome sequencing as a clinical service. Methods Five cases with were reviewed. Results In Case 1, NIPT revealed large duplication in chromosome 18p, which was supported arrayCGH amniocyte DNA, final karyotype showing mosaic tetrasomy 18p. 2, deletion the proximal long arm 18 maternal origin suspected and confirmed white cell DNA. 3, negative...
Copy number variants (CNVs) represent a substantial source of genomic variation in vertebrates and have been associated with numerous human diseases. Despite this, the extent CNVs zebrafish, an important model for disease, remains unknown. Using 80 zebrafish genomes, representing three commonly used laboratory strains one native population, we constructed genome-wide, high-resolution CNV map comprising 6,080 elements encompassing 14.6% reference genome. This amount copy is four times that...
Background: Embryologists are critical in assisted reproductive technology (ART) treatments, managing procedures that directly impact clinical outcomes. Despite the importance and high-pressure nature of their jobs, stressors is poorly known. This Asia Pacific Initiative on Reproduction (ASPIRE)-led study investigates stress dynamics among embryologists Asia-Pacific region, focusing disparities experience workplace challenges. Methods: cross-sectional survey 787 collected data about...
Fetal nuchal translucency (NT) is assessed by ultrasonography as a screening tool for aneuploidy at 11 to 13 + 6 weeks' gestation. Fetuses with increased NT but apparently normal karyotype are still higher risk of structural abnormality and range genetic syndromes, which may be related major submicroscopic chromosomal abnormalities. The aim this study was report the prevalence abnormalities in cohort euploid fetuses that presented NT.DNA extracted from stored chorionic villus samples found...
To assess the prevalence of levator ani muscle injury in Chinese women after their first delivery and investigate associated factors.A prospective observational study was conducted involving nulliparous recruited trimester pregnancy. Translabial ultrasound performed at 35-38 weeks' gestation 8 weeks postpartum three-dimensional volume datasets were obtained. Offline analysis to detect by investigators blinded details.339 women, with a mean age 30.6 ± 3.9 years, completed study. Overall, 201...
Evidence implicated the diagnostic significance of microRNAs in whole urine/urine sediments urothelial carcinoma bladder (UCB). However, contaminated blood cells patients with haematouria significantly altered expression profiles urinary microRNA, influencing test accuracy.MicroRNA urine supernatants UCB and controls without any malignancy malignant corresponding normal mucosa tissues from were determined by microRNA microarray compared to identify differentially expressed microRNAs. The...