A5051223797- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Cancer Mechanisms and Therapy
- Cancer, Lipids, and Metabolism
- Immune cells in cancer
- Inflammatory Bowel Disease
- interferon and immune responses
- MicroRNA in disease regulation
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer, Hypoxia, and Metabolism
- Hepatitis B Virus Studies
- Drug Transport and Resistance Mechanisms
- Ubiquitin and proteasome pathways
- Pediatric Hepatobiliary Diseases and Treatments
- Peroxisome Proliferator-Activated Receptors
- Circular RNAs in diseases
- Inflammasome and immune disorders
- Colorectal Cancer Surgical Treatments
- Cancer Immunotherapy and Biomarkers
- Cancer-related gene regulation
- Hepatitis C virus research
- Berberine and alkaloids research
- Wnt/β-catenin signaling in development and cancer
- Colorectal Cancer Screening and Detection
Shuguang Hospital
2021-2024
Shanghai University of Traditional Chinese Medicine
2021-2024
Harbin Medical University
2018-2021
Shandong Provincial QianFoShan Hospital
2016-2021
Shandong First Medical University
2021
Chinese University of Hong Kong
2010-2020
Murdoch Children's Research Institute
2017-2020
Cancer Genetics (United States)
2011
Molecular Oncology (United States)
2011
Aichi Cancer Center
2011
Background Immunotherapy for hepatocellular carcinoma (HCC) exhibits limited clinical efficacy due to immunosuppressive tumor microenvironment (TME). Tumor-infiltrating macrophages (TIMs) account the major component in TME, and dominance of M2 phenotype over M1 TIMs plays pivotal role sustaining character. We thus investigate effect bufalin on promoting polarization toward improve HCC immunotherapy. Methods The impact evoking antitumor immune response was evaluated immunocompetent mouse...
Enhancer of zeste homolog 2 (EZH2) is the catalytic subunit Polycomb-repressive complex (PRC2) that represses gene transcription through histone H3 lysine 27 trimethylation (H3K27me3). Although EZH2 abundantly present in various cancers, molecular consequences leading to oncogenesis remain unclear. Here, we show concordantly silences Wnt pathway antagonists operating at several subcellular compartments, which turn activate Wnt/β-catenin signaling hepatocellular carcinomas (HCC). Chromatin...
Controlling glycosylation of recombinant proteins produced by CHO cells is highly desired as it can be directed towards maintaining or increasing product quality. To further our understanding the different factors influencing glycosylation, a sub-array 79 genes and capillary electrophoresis method which simultaneously analyzes 12 nucleotides 7 nucleotide sugars; were used to generate intracellular N-glycosylation profiles. Specifically, effects sugar precursor feeding on activities analyzed...
Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide. It more prevalent in men than women. Related to this, recent genetic studies have revealed a causal role for androgen receptor (AR) hepatocarcinogenesis, but underlying molecular mechanism remains unclear. Here, we used genome-wide location and functional analyses identify critical mediator of AR signaling — cell cycle–related kinase (CCRK) that drives hepatocarcinogenesis via pathway dependent on β-catenin T factor...
Although peroxisome proliferator-activated receptor gamma (PPARγ) agonist have been shown to inhibit hepatocellular carcinoma (HCC) development, the role of PPARγ in hepatocarcinogenesis remains unclear. We investigated therapeutic efficacy against HCC. PPARγ-deficient (PPARγ+/−) and wild-type (PPARγ+/+) littermates were used a diethylnitrosamine (DEN)-induced HCC model treated with (rosiglitazone) or vehicle alone for 8 months. The effects on cell growth apoptosis examined using...
Background & AimsAberrant chromatin modification is a key feature of hepatocellular carcinoma (HCC), which characterized by strong sexual dimorphism. Both enhancer zeste homolog 2 (EZH2) and cell cycle-related kinase (CCRK) contribute to hepatocarcinogenesis, yet whether the two oncogenic factors have functional crosstalk unknown.MethodsCellular proliferation tumorigenicity upon transgenic expression RNA interference were determined colony formation soft agar assays, xenograft, orthotopic...
Background Androgen receptor (AR) signalling contributes to male predominance in hepatocellular carcinoma (HCC), which is more pronounced HBV-endemic areas. Cell cycle-related kinase (CCRK) essential for AR-induced hepatocarcinogenesis but its molecular function HBV-associated HCC remains obscure. Objective To determine the of CCRK HCC. Design Transcriptional regulation was assessed by chromatin immunoprecipitation, promoter mutation and luciferase reporter assays. Hepatocellular...
Hepatocellular carcinoma (HCC) is one of the most common cause cancer-related death worldwide. Curcumin (C) has been extensively investigated in different types malignancies, including hepatocellular carcinoma, but its physicochemical properties have significantly influenced clinical use. Several approaches are being explored to enhance curcumin's therapeutic response, combination with various drugs.
BackgroundAndrogen receptor (AR) plays a crucial role as transcription factor in promoting the development of hepatocellular carcinoma (HCC) which is prone to aberrant chromatin modifications. However, regulatory effects AR on epigenetic mediators HCC remain ill-defined. Enhancer zeste homolog 2 (EZH2), an oncogene responsible for tri-methylation histone H3 at lysine 27 (H3K27me3), was identified be overexpressed approximate 70–90% cases, prompted us investigate whether or how regulates EZH2...
Microbial factors are likely to be involved in the recurrence of Crohn's disease (CD) after bowel resection. We investigated luminal microbiota before and longitudinally surgery, relation recurrence, using 16S metagenomic techniques.In prospective Post-Operative Endoscopic Recurrence (POCER) study, fecal samples were obtained surgery 6, 12, 18 months from 130 CD patients. Endoscopy was undertaken detect defined as Rutgeerts score ≥i2, at 6 two-thirds patients all surgery. The V2 region rRNA...
Hepatocellular carcinoma (HCC) is one of the most aggressive malignant tumors, which treatment options are limited especially in advanced stage. Bufalin, major digoxin-like component traditional Chinese medicine Chansu, exhibits significant antitumor activities hepatoma cells, but potential mechanism obscure. Cell cycle-related kinase (CCRK) recently identified to be a crucial oncogenic master regulator drive hepatocarcinogenesis. Here we investigated molecular function bufalin on...
Emodin is a promising anti-cancer reagent. To improve the physicochemical and property, we modified its structure get derivative called emodin succinyl ester (ESE). Here, investigated effect of ESE on suppression hepatocellular carcinoma (HCC) underlying mechanism. Our results showed that strongly inhibited HCC cell proliferation migration in vitro. Further study revealed treatment decreased transcription level protein expression androgen receptor (AR) enhancer zeste homolog 2 (EZH2), two...
To find out risk factors for postoperative cognitive dysfunction (POCD) after coronary artery bypass grafting (CABG), and to provide basis clinical prevention of POCD. A total 88 patients who underwent CABG were surveyed with Telephone Questionnaire (TICS-M) their impairment 3, 7, 21, 90, 180 days post-surgery. The occurrence POCD was diagnosed by Neuropsychological Battery which included Vocabular Learning Test (VLT), Wisconsin Card Sorting (WCST), Trail Making (TMT) Symbol Digit Modalities...
Hepatocyte nuclear factor 1β (HNF1β) is essential for biliary development, while its genetic defect triggers the dysplasia of interlobular bile ducts, leading to life-threatening hepatitis and cholestasis. To date, this disorder has mainly been documented in neonates. Here, we report a case cholestasis an adult patient caused by de novo HNF1β mutation. A liver biopsy revealed remarkable shrinkage portal area accompanied decrease or absence veins, arteries area. Our showed that could induce...