A5055280421- MicroRNA in disease regulation
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Epigenetics and DNA Methylation
- Chromatin Remodeling and Cancer
- RNA Research and Splicing
- Cancer-related gene regulation
- Mechanisms of cancer metastasis
- RNA Interference and Gene Delivery
- Virus-based gene therapy research
- Cancer Mechanisms and Therapy
- Pancreatic and Hepatic Oncology Research
- Telomeres, Telomerase, and Senescence
- Metastasis and carcinoma case studies
- Hepatitis B Virus Studies
- Ferroptosis and cancer prognosis
- Advanced biosensing and bioanalysis techniques
- Cell death mechanisms and regulation
- TGF-β signaling in diseases
- Cancer Genomics and Diagnostics
- interferon and immune responses
- Cancer, Hypoxia, and Metabolism
- Wnt/β-catenin signaling in development and cancer
- Hepatitis C virus research
Chinese University of Hong Kong
2016-2025
Chinese University of Hong Kong, Shenzhen
2014-2025
Sichuan University
2016-2025
West China Medical Center of Sichuan University
2025
Sun Yat-sen University
2003-2024
Affiliated Hospital of Nantong University
2024
Second Affiliated Hospital of Nantong University
2024
Nantong University
2024
West China Hospital of Sichuan University
2023-2024
Sichuan Cancer Hospital
2024
Several microRNAs (miRNA) have been implicated in nasopharyngeal carcinoma (NPC), a highly invasive and metastatic cancer that is widely prevalent southern China. In this study, we report microRNA miR-26a commonly downregulated NPC specimens cell lines with important functional consequences. Ectopic expression of dramatically suppressed proliferation colony formation by inducing G(1)-phase cell-cycle arrest. We found strongly reduced the EZH2 oncogene cells. Similar to restoring miR-26...
Abstract The gut microbiota is important in the pathogenesis of energy-metabolism related diseases. We focused on interaction between intestinal bacteria and orally administered chemical drugs. Oral administration berberine (BBR) effectively treats patients with metabolic disorders. However, because BBR exhibits poor solubility, its absorption mechanism remains unknown. Here, we show that converts into absorbable form dihydroberberine (dhBBR), which has an rate 5-fold animals. reduction to...
Abstract Aims Calcific aortic valve disease (CAVD) has become an increasingly important global medical problem without effective pharmacological intervention. Accumulating evidence indicates that calcification is driven by inflammation. Interleukin-1 receptor-associated kinase M (IRAK-M) a well-known negative regulator of inflammation, but its role in CAVD remains unclear. Methods and Results Here, we stimulated interstitial cells (AVICs) with low-dose lipopolysaccharide (LPS) to mimic the...
Enhancer of zeste homolog 2 (EZH2) is the catalytic subunit Polycomb-repressive complex (PRC2) that represses gene transcription through histone H3 lysine 27 trimethylation (H3K27me3). Although EZH2 abundantly present in various cancers, molecular consequences leading to oncogenesis remain unclear. Here, we show concordantly silences Wnt pathway antagonists operating at several subcellular compartments, which turn activate Wnt/β-catenin signaling hepatocellular carcinomas (HCC). Chromatin...
Abstract Enhancer of zeste homolog 2 (EZH2) has been shown to be overexpressed in hepatocellular (HCC). We investigated the potential role EZH2 HCC tumorigenesis and examined usefulness RNA interference (RNAi) targeting as a form treatment. Lentivirus-mediated RNAi was employed knock-down expression human hepatoma cells study function evaluate treatment efficacy. effectively reduced expression. Suppression significantly their growth rate vitro markedly diminished tumorigenicity vivo....
Background and aims A previous study of ours indicated that enhancer zeste homologue 2 (EZH2) plays an important role in hepatocellular carcinoma (HCC) tumorigenesis. The aim the present was to investigate potential diagnostic utility EZH2 HCC. Methods Immunohistochemistry performed examine expression dynamics two independent surgical cohorts HCC non-malignant liver tissues develop a yield EZH2, HSP70 GPC3 for detection. performances three-marker panel were re-evaluated by using additional...
zMicroRNAs (miRNAs) are endogenously expressed small noncoding RNAs that regulate approximately one-third of human genes at post-transcription level. Previous studies have shown miRNAs were implicated in many cellular processes and participated the progress various tumors including hepatocellular carcinoma (HCC). Among all miRNAs, let-7 family is well recognized to play pivotal roles tumorigenesis by functioning as potential growth suppressor. In present study, we aimed investigate role...
It was suggested that the enhancer of zeste homolog 2 (EZH2) gene is a putative candidate oncogene in several types human cancer. The potential oncogenic role EZH2 and its clinical/prognostic significance, however, ovarian carcinoma are unclear. In this study, expression examined by immunohistochemistry (IHC) cohorts normal tumorous tissues. High none ovaries, 3% cystadenomas, 23% borderline tumors 50% carcinomas, respectively. high positively correlated with an ascending histological grade...
Rationale: Bone morphogenic protein (BMP)4 can stimulate superoxide production and exert proinflammatory effects on the endothelium. The underlying mechanisms of how BMP4 mediates endothelial dysfunction hypertension remain elusive. Objective: To elucidate cellular pathways by which BMP4-induced is mediated through oxidative stress–dependent upregulation cyclooxygenase (COX)-2. Methods Results: Impaired endothelium-dependent relaxations, exaggerated contractions, reactive oxygen species...
Abstract The detailed biological functions of circular RNA (circRNA) are largely unexplored. Using circRNA sequencing, we identified 169 differentially expressed in pancreatic ductal adenocarcinoma (PDAC) cells compared with nontumor human epithelial cells. Among them, circFOXK2 was validated significant upregulation PDAC and 63% primary tumors (53 84). promoted cell growth, migration, invasion involved cell-cycle progression apoptosis. contained multiple miRNA binding sites, functioning as...
Abstract Chromatin remodeling has emerged as a hallmark of gastric cancer, but the regulation chromatin regulators other than genetic change is unknown. Helicobacter pylori causes epigenetic dysregulation to promote carcinogenesis, roles and functions microRNAs (miRNA) in this multistage cascade are not fully explored. In study, miRNA expression preneoplastic neoplastic lesions murine stomachs induced by H. N-methyl-N-nitrosourea (MNU) was profiled array. miR-490-3p exhibited progressive...
Non-coding RNA refers to a large group of endogenous molecules that have no protein coding capacity, while having specialized cellular and molecular functions. They possess wide range functions such as the regulation gene transcription translation, post-transcriptional modification, epigenetic landscape establishment, scaffolding cofactors recruitments. are further divided into small non-coding RNAs with size < 200nt (e.g. miRNA, piRNA) long >= lincRNA, NAT). Increasing evidences suggest...
Exosomes are microvesicles, measuring 30-100 nm in diameter. They widely distributed body fluids, including blood, bile, urine and saliva. Cancer-derived exosomes carry a wide variety of DNA, RNA, proteins lipids, may serve as novel biomarkers cancer.To summarize the performance exosomal cancer diagnosis prognosis.Relevant publications literature were identified by search "PubMed" database up to September 11, 2018. The quality included studies was assessed QUADAS-2 REMARK. For assessment...
Abstract Background Transfer RNA-derived fragments (tRFs) are a new class of small non-coding RNAs. Recent studies suggest that tRFs participate in some pathological processes. However, the biological functions and mechanisms non-small cell lung cancer (NSCLC) largely unknown. Methods Differentially expressed were identified by tRF tiRNA sequencing using 9 pairs pre- post-operation plasma from patients with NSCLC. Quantitative real-time PCR (qRT-PCR) fluorescence situ hybridization (FISH)...
Circular RNAs (circRNAs) play important roles in many biological processes. However, the detailed mechanism underlying critical of circRNAs cancer remains largely unexplored. We aim to explore molecular mechanisms circRTN4 with pancreatic ductal adenocarcinoma (PDAC).CircRTN4 expression level was examined PDAC primary tumors. The oncogenic tumor growth and metastasis were studied mouse models. Bioinformatics analysis, luciferase assay miRNA pulldown performed study novel...