A5087399049- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Crystallography and molecular interactions
- Organometallic Complex Synthesis and Catalysis
- Metal-Catalyzed Oxygenation Mechanisms
- Metal complexes synthesis and properties
- Magnetism in coordination complexes
- Porphyrin and Phthalocyanine Chemistry
- Synthesis and characterization of novel inorganic/organometallic compounds
- History and advancements in chemistry
- Coordination Chemistry and Organometallics
- Vanadium and Halogenation Chemistry
- Polyoxometalates: Synthesis and Applications
- DNA and Nucleic Acid Chemistry
- Oxidative Organic Chemistry Reactions
- Metal-Organic Frameworks: Synthesis and Applications
- Advanced Photocatalysis Techniques
- Nanoparticles: synthesis and applications
- Catalytic Cross-Coupling Reactions
- Various Chemistry Research Topics
- Synthesis and Properties of Aromatic Compounds
- Catalytic C–H Functionalization Methods
- Inorganic Chemistry and Materials
- Advanced Nanomaterials in Catalysis
- Hormonal Regulation and Hypertension
Chinese University of Hong Kong
2015-2024
Shatin Hospital
2015-2020
State Key Laboratory of Synthetic Chemistry
2018-2019
University of Hong Kong
2010-2012
Army Medical University
2012
Daping Hospital
2012
Hong Kong Baptist University
2007
California Institute of Technology
1997
University of Illinois Urbana-Champaign
1997
Efficient photocatalytic solar-to-H 2 conversion is pivotal to zero-carbon energy supply.
The efficiency of photocatalytic inactivation towards <italic>Escherichia coli</italic> K-12 is highly dependent on the dominantly exposed facets BiOBr.
AimsThe present study investigated whether or not calcitriol, an active form of vitamin D, protects against renovascular dysfunction in hypertension and, if so, such protection alters the expression key proteins involved that dysfunction.
Abstract We performed a comprehensive investigation of the toxicity ZnO and TiO 2 nanoparticles using Escherichia coli as model organism. Both materials are wide band gap n-type semiconductors they can interact with lipopolysaccharide molecules present in outer membrane E. , well produce reactive oxygen species (ROS) under UV illumination. Despite similarities their properties, response bacteria to two nanomaterials was fundamentally different. When ROS generation is observed, nanomaterial...
Rationale: Bone morphogenic protein (BMP)4 can stimulate superoxide production and exert proinflammatory effects on the endothelium. The underlying mechanisms of how BMP4 mediates endothelial dysfunction hypertension remain elusive. Objective: To elucidate cellular pathways by which BMP4-induced is mediated through oxidative stress–dependent upregulation cyclooxygenase (COX)-2. Methods Results: Impaired endothelium-dependent relaxations, exaggerated contractions, reactive oxygen species...
This study explores a bottom-up approach toward negatively curved carbon allotropes from octabenzo[8]circulene, nanographene. Stepwise chemical reduction reactions of octabenzo[8]circulene with alkali metals lead to unique highly reduced hydrocarbon pentaanion, which is revealed by X-ray crystallography suggesting local view for the and metal intercalation processes allotropes. Polymerization tetrabromo derivative nickel-mediated Yamamoto coupling reaction results in new type porous...
Highly effective yet chemoselective chemical transformation strategies enable the facile access and precise modification of complicated biomacromolecules. In particular, application desulfurization chemistry expands dimension protein synthesis with cysteine-based peptide ligation. Considering existing methods, a milder, faster, easier strategy is still required for increasing complexity proteins by synthesis. Herein, we report superfast based on tetraethylborate effectively chemoselectively...
Three interesting coordination polymers, [Ag4(μ4-hmt)(μ4-η2-nda)2]·2H2O (1), [Ag2(μ-hmt)2(μ-bi-η2-bna)]·2H2O·MeCN (2), and [Ag2(μ4-hmt)(η2-hna)(MeCN)](hna)·H2O (3) (hmt = hexamethylenetetramine, nda 2,6-naphthalenedicarboxylate, bna 2,2'-dihydroxy-1,1'-binaphthalene-3,3'-dicarboxylate, hna 1-hydroxy-2-naphthalenecarboxylate), were obtained from the reaction of silver(I) aromatic carboxylates in MeCN solution with hmt CH2Cl2 via liquid diffusion method. In these complexes, ligate to metal...
Aims: The role of endothelium-derived contracting factors (EDCFs) in regulating renovascular function is yet to be elucidated hypertension (RH). current study investigated whether oxidative stress-dependent cyclooxygenase (COX)-2-derived prostaglandin F2α (PGF2α) impairs endothelial renal arteries hypertensive rats (RHR). Results: Renal was induced by artery stenosis both kidneys using the 2-kidney 2-clip model. Acute treatment with reactive oxygen species (ROS) scavengers, COX-2 inhibitors,...
Endothelial dysfunction plays a crucial role in the development of diabetic vasculopathy. Our initial quantitative PCR results showed an increased miR-200c expression arteries from mice and patients with diabetes. However, whether is involved endothelial unknown. Overexpression impaired endothelium-dependent relaxations (EDRs) nondiabetic mouse aortas, whereas suppression by anti–miR-200c enhanced EDRs db/db mice. suppressed ZEB1 expression, overexpression ameliorated induced or associated...
Brown-colored TiO<sub>2</sub> with the absorption edge in red light was fabricated using a facile one-step treatment NaH solutions.
Zinc oxysulfide (ZnO<sub>0.6</sub>S<sub>0.4</sub>) nanoparticles were prepared and used as an effective visible-light-driven (VLD) photocatalyst for the inactivation of <italic>Escherichia coli</italic> K-12 first time.
The development of highly active and selective metal catalysts for efficient oxidation hydrocarbons identification the reactive intermediates in catalysis are long-standing challenges. In rapid hydrocarbon catalyzed by ruthenium(IV) -(III) porphyrins, putative Ru(V)-oxo remain elusive. Herein we report that arylruthenium(III) porphyrins oxidation. Using catalyst [RuIII(TDCPP)(Ph)(OEt2)] (H2TDCPP = 5,10,15,20-tetrakis(2,6-dichlorophenyl)porphyrin), C-H bonds various with oxidant m-CPBA at...
AimsEndothelial dysfunction is caused by reduced nitric oxide (NO) bioavailability and/or over-produced reactive oxygen species (ROS). The present study investigated a vascular benefit of AVE3085, an endothelial synthase (eNOS) enhancer, in preserving function diabetic mice and the mechanisms involved.
Six cubane-type complexes comprising similar [M4O4]n+ cores [M = Mn(II), Co(II), Ni(II), Zn(II) or Cd(II)] synthesised in a facile route utilizing the gem-diol form of di-2-pyridyl ketone as ligand have been characterised by X-ray structural analysis. Complex 1 crystallizes cubic space group I 3d, which is highest symmetry documented cubane-like manganese compounds to date, while other crystallize much lower crystallographic symmetries. The four metal ions and bridging alkoxo oxygen atoms...
The solid compound formulated as [Mn(4,4′-bpy)2(H2O)4][ClO4]2·(4,4′-bpy)4 (bpy = bipyridine) has been shown by single-crystal structural analysis to be a three-dimensional network with triangular channels, which are constructed mononuclear [Mn(4,4′-bpy)2(H2O)4]2+ cations and 4,4′-bpy molecules through extensive hydrogen-bonds π–π interactions.
A series of N₂O₂ tripodal tetradentate ligands derived from di-/tetra-tert-butyl substituted 2-[bis(2-hydroxybenzyl)aminomethyl]X (X = pyridine and benzimidazole) (H₂L(n) (n 1-4)) 8-[bis(3,5-di-tert-butyl-2-hydroxybenzyl)]aminoquinoline (H₂L⁵) were synthesised through a 4-step reaction scheme involving sequential formylation, reduction, bromination alkylation. Treatment H₂L(n) 1-5) with [WO₂Cl₂(dme)] (dme 1,2-dimethoxyethane) in the presence triethylamine gave corresponding...
The unique cobalt(I)-NHC complex [Co(IEt)4][BPh4] (1) (IEt = 1,3-diethyl-4,5-dimethylimidazole-2-ylidene) and its analogues employing other carbene ligands were prepared by the reactions of [Co(PPh3)3Cl] with free followed anion exchange. X-ray diffraction revealed 1 features a homoleptic cation [Co(IEt)4]+ square-planar geometry. Electrochemical studies showed complexes support redox series [Co(IEt)4]+/2+/3+, which divalent has been synthesized structurally characterized as in...
The mechanisms underlying the effect of renin-angiotensin-aldosterone system (RAAS) inhibition on endothelial dysfunction in type 2 diabetes are incompletely understood. This study explored a causal relationship between RAAS activation and oxidative stress involved diabetes-associated dysfunction. Daily oral administration valsartan or enalapril at 10 mg/kg/day to db/db mice for 6 weeks reversed blunted acetylcholine-induced endothelium-dependent dilatations, suppressed upregulated...
Abstract The oxidation of light alkanes that is catalyzed by heme and nonheme iron enzymes widely proposed to involve highly reactive {Fe V O} species or IV ligand cation radicals. identification these high‐valent the development an iron‐catalyzed under mild conditions are vital importance. Herein, a combination tridentate bidentate ligands was used for generation {FeO} species. A method employs [Fe III (Me 3 tacn)(Cl‐acac)Cl] + as catalyst in presence oxone developed hydrocarbons,...
A new strategy to construct electron-precise B–B single bond via direct borylene insertion into B–H is described. Reduction of bromoborylene stabilized by carborane-fused silylenes with 2 equiv sodium gives a compound bond. Both experimental and density functional theory results suggest that such an formed in situ generated