A5101470629- Extracellular vesicles in disease
- Obstructive Sleep Apnea Research
- Lipid metabolism and biosynthesis
- Neuroscience of respiration and sleep
- Cardiovascular Disease and Adiposity
- Cancer-related molecular mechanisms research
- Microbial Metabolic Engineering and Bioproduction
- Cancer-related gene regulation
- Ubiquitin and proteasome pathways
- Adipose Tissue and Metabolism
- Atherosclerosis and Cardiovascular Diseases
- Cancer, Hypoxia, and Metabolism
- Eicosanoids and Hypertension Pharmacology
- Effects and risks of endocrine disrupting chemicals
- Inflammation biomarkers and pathways
- Ionic liquids properties and applications
- Photosynthetic Processes and Mechanisms
- MicroRNA in disease regulation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Birth, Development, and Health
- Surfactants and Colloidal Systems
- Heart Rate Variability and Autonomic Control
- Berberine and alkaloids research
- Paraoxonase enzyme and polymorphisms
- Sulfur Compounds in Biology
Capital Medical University
2016-2025
Beijing Institute of Water
2018-2025
Beijing Anzhen Hospital
2016-2024
Northeast Forestry University
2023-2024
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2016-2023
Wenzhou Medical University
2016-2023
Shanghai East Hospital
2023
Tongji University
2017-2023
Tongji Hospital
2017-2023
Zhoukou Normal University
2021-2022
The lipid droplet (LD) is a universal organelle governing the storage and turnover of neutral lipids. Mounting evidence indicates that elevated intramuscular triglyceride (IMTG) in skeletal muscle LDs closely associated with insulin resistance Type 2 Diabetes Mellitus (T2DM). Therefore, identification LD proteome will provide some clues to dissect mechanism connecting IMTG T2DM. In present work, we identified 324 LD-associated proteins mouse through mass spectrometry analysis. Besides...
Halogen-free, low-cost alkyl sulfate-based surface active ionic liquids (SAILs), 1-butyl-3-methylimidazolium dodecyl sulfate ([C(4)mim][C(12)SO(4)]), and N-butyl-N-methylpyrrolidinium ([C(4)MP][C(12)SO(4)]) were easily synthesized through ion exchange reaction. The aggregation behaviors of [C(4)mim][C(12)SO(4)] [C(4)MP][C(12)SO(4)] in aqueous solution investigated by tension, electric conductivity, static fluorescence quenching. Both have rather lower cmc, γ(cmc) values higher pC(20), π(cmc)...
Significance Endothelial dysfunction plays a crucial role in the development of diabetic vasculopathy, but mechanisms are not fully understood. In this study, we have revealed previously undefined importance serum exosomes regulating endothelial function and vascular homeostasis diabetes. Through comparative proteomics analysis, arginase1 was found enriched can be transferred to cells inhibit NO production, thus impairing function. This is cell-to-cell communication mechanism first...
The mechanisms underlying ageing-induced vascular remodelling remain unclear. This study investigates the role and of cytoplasmic deacetylase sirtuin 2 (SIRT2) in remodelling.
Rapid urbanization has led to increasingly prominent urban heat island phenomena and social inequality. It is urgent quantify the threshold area of parks from multiple perspectives maximize cooling effect improve equity park services. Using 33 in Harbin City as research objects, four indices, i.e., intensity (PCI), distance (PCD), (PCA), efficiency (PCE), were used explore value (TVoE) size. The OD (origin-destination) matrix model was constructed assess spatial accessibility community...
Abstract Background The potential role of Klebsiella pneumoniae ( K.pn ) in hypertension development has been emphasized, although the specific mechanisms have not well understood. Bacterial extracellular vesicles (BEVs) released by Gram-negative bacteria modulate host cell functions delivering bacterial components to cells. Endothelial dysfunction is an important early event pathogenesis hypertension, yet impact -secreted EVs EVs) on endothelial function remains unclear. This study aimed...
Storage of cellular triacylglycerols (TAGs) in lipid droplets (LDs) has been linked to the progression many metabolic diseases humans, and development biofuels from plants microorganisms. However, biogenesis dynamics LDs are poorly understood. Compared with other organisms, bacteria seem be a better model system for studying LD biology, because they relatively simple highly efficient converting biomass TAG. We obtained purified Rhodococcus sp. RHA1, bacterium that can produce TAG carbon...
Poly(ε-caprolactone) (PCL) has received considerable attention in bone tissue engineering. However, the lack of osteoinductive ability PCL limits its application. The aim this study was to directly attach morphogenetic protein-2 (BMP-2) scaffolds by a crosslinking conjugation method and investigate whether bound BMP-2 maintained bioactivity vitro. Immunofluorescent staining against quantitative enzyme-linked immunosorbent assay measurements demonstrated that successfully immobilized on...
Endothelial dysfunction plays a crucial role in the development of diabetic vasculopathy. Our initial quantitative PCR results showed an increased miR-200c expression arteries from mice and patients with diabetes. However, whether is involved endothelial unknown. Overexpression impaired endothelium-dependent relaxations (EDRs) nondiabetic mouse aortas, whereas suppression by anti–miR-200c enhanced EDRs db/db mice. suppressed ZEB1 expression, overexpression ameliorated induced or associated...
Aging associated cognitive decline has been linked to dampened neural stem/progenitor cells (NSC/NPCs) activities manifested by decreased proliferation, reduced propensity produce neurons, and increased differentiation into astrocytes. While gene transcription changes objectively reveal molecular alterations of undergoing various biological processes, the search for mechanisms underlying aging NSC/NPCs confronted enormous heterogeneity in cellular compositions brain complex microenvironment...
Intermittent hypoxia (IH), the key property of obstructive sleep apnea (OSA), is closely associated with endothelial dysfunction. Endothelial‐cell‐specific molecule‐1 (ESM‐1, Endocan) a novel, reported molecule linked to The aim this study evaluate effect IH on ESM‐1 expression and role in We found that serum concentration ESM‐1, inter‐cellular adhesion (ICAM‐1), vascular cell (VCAM‐1) significantly higher patients OSA than healthy volunteers ( p < 0.01). hypoxia‐inducible factor‐1 alpha...
Background: Endothelial barrier dysfunction plays a key role in atherosclerosis progression. The primary pathology of obstructive sleep apnea-hypopnea syndrome is chronic intermittent hypoxia (IH), which induces reactive oxygen species (ROS) overproduction, endothelial injury, and atherosclerosis. Salidroside, typical pharmacological constituent Rhodiola genus, has documented antioxidative, cardiovascular protective effects. However, whether salidroside can improve IH-aggravated not been...
Abstract Systemic administration of δ‐opioid receptor (DOR) agonists decreases immobility in the forced swim test (FST) and increases brain‐derived neurotrophic factor (BDNF) mRNA expression rats, indicating that DOR may have antidepressant‐like effects. The aim this study was to investigate effects central endogenous opioid peptides on behavior FST brain BDNF rats. Effects opioids were compared with those produced by intracerebroventricular a selective non‐peptidic agonist (+)BW373U86....
Ectopically, expression of defined factors could reprogram mammalian somatic cells into induced pluripotent stem (iPSCs), which initiates a new strategy to obtain cell lines. Attempts have been made generate buffalo by culturing primary germ or inner mass, but the efficiency is extremely low. Here, we report successful method fetal fibroblasts (BFFs) [buffalo (biPSCs)] transduction (Oct4, Sox2, Klf4, and c-Myc) using retroviral vectors. The established biPSCs displayed typical morphological...
Obstructive sleep apnea-hypopnea syndrome, a breathing disorder in which chronic intermittent hypoxia (CIH) is the primary pathology, associated with multiple cardiovascular diseases. However, whether and how CIH may affect cardiac remodeling following myocardial infarction (MI) remains unknown.To determine exposure at different periods of MI exacerbate post-MI heart failure to identify mechanisms underlying CIH-exacerbated remodeling.Adult male mice were subjected (4 weeks) without or 8...
Hyperhomocysteinemia is associated with an increased risk for cardiovascular diseases through oxidative stress. Salidroside active ingredient of the root Rhodiola rosea documented antioxidative, antihypoxia and neuroprotective properties. However, vascular benefits salidroside against endothelial dysfunction have yet to be explored. The present study, therefore, aimed investigate protective effect on homocysteine-induced dysfunction. Functional studies rat aortas were performed delineate...