A5055673021- Neurotransmitter Receptor Influence on Behavior
- Memory and Neural Mechanisms
- Neuroscience and Neuropharmacology Research
- Stress Responses and Cortisol
- Receptor Mechanisms and Signaling
- Neuroendocrine regulation and behavior
- Cannabis and Cannabinoid Research
- Nicotinic Acetylcholine Receptors Study
- Neuropeptides and Animal Physiology
- Neural and Behavioral Psychology Studies
- Tryptophan and brain disorders
- Nerve injury and regeneration
- Neuroinflammation and Neurodegeneration Mechanisms
- Nuclear Receptors and Signaling
- Cognitive Abilities and Testing
- Biochemical effects in animals
- Hormonal and reproductive studies
- Attention Deficit Hyperactivity Disorder
- Neural dynamics and brain function
- Sex and Gender in Healthcare
- Neurogenesis and neuroplasticity mechanisms
- Visual perception and processing mechanisms
- Hormonal Regulation and Hypertension
- Photoreceptor and optogenetics research
- Substance Abuse Treatment and Outcomes
University of Pittsburgh
2016-2025
Leipzig University
2021
Yale University
2008-2014
Connecticut Mental Health Center
2008-2012
Miami University
2010
Medical University of South Carolina
2006-2008
University of Michigan
2003-2006
Differences between men and women in alcohol abuse prevalence have long been attributed to social hormonal factors. It is, however, becoming apparent that sex differences substance dependence are also influenced by genetic Using a four core genotype mouse model enables dissociation of chromosomal gonadal sex, we show habitual responding for reinforcement is mediated chromosome complement independent phenotype. After moderate instrumental training, male (XY) mice became insensitive outcome...
Extinction therapy has been proposed as a method to reduce the motivational impact of drug-associated cues prevent relapse. Cue extinction therapy, however, takes place in novel context (e.g., treatment facility), and is unlikely be effective due specificity extinction. We tested hypothesis that d -cycloserine (DCS), which enhances other procedures, would enhance cocaine-associated cue-induced reinstatement. Male Sprague Dawley rats were trained self-administer cocaine associated with cue....
Drug addiction is a chronic disorder associated with recurrent craving and relapse often precipitated by the presence of drug-associated stimuli. Pharmacological behavioral treatments that disrupt stimulus memories could be beneficial in treatment addictive disorders. Memory restabilization (or reconsolidation) following retrieval drug-paired stimuli depends upon amygdala. Here we assessed whether amygdalar PKA required for reconsolidation an appetitive, cocaine-paired stimulus. Rats were...
We recorded neuronal activity simultaneously in the medial and lateral regions of dorsal striatum as rats learned an operant task. The task involved making head entries into a response port followed by movements to collect rewards at adjacent reward port. availability sucrose was signaled acoustic stimulus. During training, animals showed increased rates responding came move rapidly selectively, following stimulus, from Behavioral "devaluation" studies, pairing with lithium chloride,...
The development of addictive behavior is marked by a loss behavioral flexibility. In part, this due to an increase in the ability environmental stimuli elicit responding and decreased importance action-outcome relationship control. It has previously been demonstrated that both inactivation dopamine (DA) infusions infralimbic prefrontal cortex (PFC) can restore flexibility paradigms measuring habitual reward seeking. Here, we investigated mechanism which cortical DA would act enable...
Repeated drug use has long-lasting effects on plasticity throughout the brain's reward and memory systems. Environmental cues that are associated with drugs of abuse can elicit craving relapse, but neural circuits responsible for driving drug-cue-related behaviors have not been well delineated, creating a hurdle development effective relapse prevention therapies. In this study, we used cocaine+cue self-administration paradigm followed by cue re-exposure to establish strength association...
Abstract Systemic administration of δ‐opioid receptor (DOR) agonists decreases immobility in the forced swim test (FST) and increases brain‐derived neurotrophic factor (BDNF) mRNA expression rats, indicating that DOR may have antidepressant‐like effects. The aim this study was to investigate effects central endogenous opioid peptides on behavior FST brain BDNF rats. Effects opioids were compared with those produced by intracerebroventricular a selective non‐peptidic agonist (+)BW373U86....
Successful addiction treatment depends on maintaining long-term abstinence, making relapse prevention an essential therapeutic goal. However, exposure to environmental cues associated with drug use often thwarts abstinence efforts by triggering using memories that drive craving and relapse. We sought develop a dual approach for weakening cocaine through phosphoproteomic identification of targets regulated in opposite directions memory extinction compared reconsolidation male Sprague-Dawley...
Abstract Post-traumatic stress disorder (PTSD) is more prevalent in women than men, yet much remains to be determined regarding the mechanism underlying this sex difference. Clinical and preclinical studies have shown that low estradiol levels during extinction of fear conditioning rodents (i.e., cue exposure therapy humans) leads poor consolidation increased recall. The renin–angiotensin system (RAS) also associated with stress-related pathologies, RAS antagonists can enhance males....