A5079509060- Obsessive-Compulsive Spectrum Disorders
- Neurotransmitter Receptor Influence on Behavior
- Autism Spectrum Disorder Research
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Eating Disorders and Behaviors
- Neuroscience and Neuropharmacology Research
- Attention Deficit Hyperactivity Disorder
- Receptor Mechanisms and Signaling
- Neural dynamics and brain function
- Neurological disorders and treatments
- Neuroendocrine regulation and behavior
- Functional Brain Connectivity Studies
- Neural and Behavioral Psychology Studies
- Photoreceptor and optogenetics research
- Neuroscience and Neural Engineering
- Memory and Neural Mechanisms
- Hypothalamic control of reproductive hormones
- Regulation of Appetite and Obesity
- Nicotinic Acetylcholine Receptors Study
- Mental Health Research Topics
- Transcranial Magnetic Stimulation Studies
- Child and Adolescent Psychosocial and Emotional Development
- Neuropeptides and Animal Physiology
- Obesity, Physical Activity, Diet
- Tryptophan and brain disorders
University of Pittsburgh
2016-2025
Center for the Neural Basis of Cognition
2015-2025
Carnegie Mellon University
2019-2025
University of Pittsburgh Medical Center
2023-2024
Center for Neurosciences
2022
Duke University
2021
Wake Forest University
2021
Trinity College
2021
Columbia University
2009-2017
University of Washington
2017
Although cortico-striato-thalamo-cortical (CSTC) circuit dysregulation is correlated with obsessive compulsive disorder (OCD), causation cannot be tested in humans. We used optogenetics mice to simulate CSTC hyperactivation observed OCD patients. Whereas acute orbitofrontal cortex (OFC)-ventromedial striatum (VMS) stimulation did not produce repetitive behaviors, repeated over multiple days generated a progressive increase grooming, mouse behavior related OCD. Increased grooming persisted...
Abstract Compulsive behaviors are a hallmark symptom of obsessive compulsive disorder (OCD). Striatal hyperactivity has been linked to behavior generation in correlative studies humans and causal rodents. However, the contribution two distinct striatal output populations treatment is unknown. These direct indirect pathway-projecting spiny projection neurons (SPNs) have classically thought promote or suppress actions, respectively, leading long-held hypothesis that increased relative pathway...
Hyperactivity in striatum is associated with compulsive behaviors obsessive-compulsive disorder (OCD) and related illnesses, but it unclear whether this hyperactivity due to intrinsic striatal dysfunction or abnormalities corticostriatal inputs. Understanding the cellular circuit properties underlying could help inform optimization of targeted stimulation treatments for behavior disorders. To investigate synaptic that may underlie relevant OCD, we used Sapap3 knock-out ( -KO) mouse model...
Obsessive-compulsive disorder (OCD) is a chronic, disabling condition with inadequate treatment options that leave most patients substantial residual symptoms. Structural, neurochemical, and behavioral findings point to significant role for basal ganglia circuits the glutamate system in OCD. Genetic linkage association studies OCD SLC1A1, which encodes neuronal glutamate/aspartate/cysteine transporter excitatory amino acid 3 (EAAT3)/excitatory 1 (EAAC1). However, no previous have...
Compulsive behaviors are a core feature of obsessive-compulsive spectrum disorders but appear across broad psychological conditions. It is thought that compulsions reflect failure to override habitual "stamped in" through repeated practice and short-term distress reduction. Animal models suggest possible causal role the orbitofrontal cortex (OFC) in compulsive behaviors, human studies have largely been limited by correlational designs. The goal this study was establish first experimental...
Numerous studies have investigated response inhibition (RI) in obsessive-compulsive disorder (OCD), with many reporting that OCD patients demonstrate deficits RI as compared to controls. However, reported effect sizes tend be modest and results been inconsistent, some finding intact OCD. To date, no study has examined the of medications on patients.We analyzed from a stop-signal task probe 65 (32 whom were medicated) 58 healthy controls (HCs).There was statistically significant difference...
Obsessive compulsive disorder (OCD) is associated with disruption of sensorimotor gating, which may contribute to difficulties inhibiting intrusive thoughts and rituals. Neural mechanisms underlying these disturbances are unclear; however, striatal dopamine implicated in regulation gating OCD pathophysiology. The goal this study was examine the relationships between behavior, receptor levels Sapap3 knockout mice (KOs), a widely used preclinical model system for research. We found trend...
Obsessive-compulsive disorder (OCD) is a chronic psychiatric illness associated with altered function in cortico-striatal-thalamo-cortical (CSTC) circuits. In this pilot study, we examined differential RNA expression the thalamus using postmortem human brain tissue samples from 11 subjects OCD and 10 unaffected subjects. We individually dissected mediodorsal magnocellular, parvocellular, ventral anterior nuclei, which participate orbitofrontal cingulate CSTC circuits most frequently OCD,...