A5059026862- Neuroscience and Neuropharmacology Research
- Neural dynamics and brain function
- Parkinson's Disease Mechanisms and Treatments
- Advanced Memory and Neural Computing
- Adenosine and Purinergic Signaling
- Obsessive-Compulsive Spectrum Disorders
- Autism Spectrum Disorder Research
- Neurological disorders and treatments
- Photoreceptor and optogenetics research
- Receptor Mechanisms and Signaling
- Neurotransmitter Receptor Influence on Behavior
- Vagus Nerve Stimulation Research
- Genetic Neurodegenerative Diseases
- Nicotinic Acetylcholine Receptors Study
- Photochromic and Fluorescence Chemistry
- Biochemical effects in animals
- Conducting polymers and applications
University of Pittsburgh
2022-2024
Northwestern University
2018-2020
University of Connecticut
2013-2020
Abstract Compulsive behaviors are a hallmark symptom of obsessive compulsive disorder (OCD). Striatal hyperactivity has been linked to behavior generation in correlative studies humans and causal rodents. However, the contribution two distinct striatal output populations treatment is unknown. These direct indirect pathway-projecting spiny projection neurons (SPNs) have classically thought promote or suppress actions, respectively, leading long-held hypothesis that increased relative pathway...
LRRK2 is a kinase expressed in striatal spiny projection neurons (SPNs), cells which lose dopaminergic input Parkinson's disease (PD). R1441C and G2019S are the most common pathogenic mutations of LRRK2. How these alter structure function individual synapses on direct indirect pathway SPNs unknown may reveal pre-clinical changes dopamine-recipient that predispose toward disease. Here, knock-in mice enabled thorough evaluation dendritic spines pathway-identified SPNs. Biochemical synaptic...
Adenosine might be the most widespread neuromodulator in brain, but its effects on inhibitory transmission neocortex are not understood. Here we report that adenosine suppresses to layer 2/3 pyramidal neurons via activation of presynaptic A1 receptors. We present evidence for functional A2A receptors, which have a weak modulatory effect A1-mediated suppression, at about 50% synapses neurons. excitatory and different extent, can change excitation-inhibition balance set bidirectionally,...
Endogenous extracellular adenosine level fluctuates in an activity-dependent manner and with sleep–wake cycle, modulating synaptic transmission short-term plasticity. Hebbian-type long-term plasticity introduces intrinsic positive feedback on weight changes, making them prone to runaway dynamics. We previously demonstrated that co-occurring, weight-dependent heterosynaptic can robustly prevent Here we show at neocortical synapses slices from rat visual cortex, modulates the dependence of...
Inhibition in neuronal networks of the neocortex serves a multitude functions, such as balancing excitation and structuring activity space time. Plasticity inhibition is mediated by changes at both inhibitory synapses, well excitatory synapses on neurons. Using slices from visual cortex young male rats, we describe novel form plasticity neurons, weight-dependent heterosynaptic plasticity. Recordings connected pyramid-to-interneuron pairs confirm that postsynaptic alone can induce long-term...
Abstract Compulsive behaviors are a hallmark symptom of obsessive compulsive disorder (OCD). Striatal hyperactivity has been linked to behavior generation in correlative studies humans and causal rodents. However, the contribution two distinct striatal output populations treatment is unknown. These direct indirect pathway-projecting spiny projection neurons (SPNs) have classically thought promote or suppress actions, respectively, leading long-held hypothesis that increased relative pathway...
Ethanol is one of the most commonly used substances in world. Behavioral effects alcohol are well described, however, cellular mechanisms its action poorly understood. There an apparent contradiction between measurable behavioral changes produced by low concentrations ethanol, and lack evidence synaptic at these concentrations. Furthermore, ethanol on transmission neocortex Here, we set to determine excitatory neocortex. We show that 1-50 mm suppresses layer 2/3 pyramidal neurons rat visual...
ABSTRACT LRRK2 is a kinase expressed in striatal spiny projection neurons (SPNs), cells which lose dopaminergic input Parkinson’s disease (PD). R1441C and G2019S are the most common pathogenic mutations of LRRK2. How these alter structure function individual synapses on direct indirect pathway SPNs unknown may reveal pre-clinical changes dopamine-recipient that predispose towards disease. Here, knock-in mice enabled thorough evaluation dendritic spines pathway-identified SPNs. Biochemical...